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. 1977 Jun;53(620):310–314. doi: 10.1136/pgmj.53.620.310

Haematological abnormalities in acute pancreatitis. A prospective study.

D Murphy, C W Imrie, J F Davidson
PMCID: PMC2496644  PMID: 887529

Abstract

Twenty-five patients with acute pancreatitis were studied prospectively in the first week of their admission using haematological and coagulation tests. Platelet counts initially fell and later returned to admission levels. Rising levels of plasma fibrinogen were recorded. The kaolin cephalin clotting time was shorter than its control in twenty-one patients. Eighteen patients had elevated fibrinogen degradation products and fourteen had a positive ethanol gelation test. It is suggested that by taking into account the results in series of individual patients a degree of intravascular coagulation may be a common feature of acute pancreatitis. In one patient (presented in detail) strong evidence for disseminated intravascular coagulation was found

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CLAUSS A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957 Apr;17(4):237–246. doi: 10.1159/000205234. [DOI] [PubMed] [Google Scholar]
  2. Fedder G., Prakke E. M., Vreeken J. On the early detection of intravascular coagulation. An experimental study. Thromb Diath Haemorrh. 1972 Jul 31;27(3):365–376. [PubMed] [Google Scholar]
  3. Godal H. C., Abildgaard U. Gelation of soluble fibrin in plasma by ethanol. Scand J Haematol. 1966;3(5):342–350. doi: 10.1111/j.1600-0609.1966.tb02378.x. [DOI] [PubMed] [Google Scholar]
  4. Greipp P. R., Brown J. A., Gralnick H. R. Defibrination in acute pancreatitis. Ann Intern Med. 1972 Jan;76(1):73–76. doi: 10.7326/0003-4819-76-1-73. [DOI] [PubMed] [Google Scholar]
  5. Gurewich V. Letter: Causes of a negative ethanol gelation test in diffuse intravascular coagulation. Thromb Diath Haemorrh. 1974 Sep 30;32(1):243–244. [PubMed] [Google Scholar]
  6. Hirayama A., Uehara S., Itagaki Y., Izumiyama S., Kudo M. [Coagulation study in pancreatitis (author's transl)]. Rinsho Ketsueki. 1974 Feb;15(2):171–176. [PubMed] [Google Scholar]
  7. Imrie C. W., Whyte A. S. A prospective study of acute pancreatitis. Br J Surg. 1975 Jun;62(6):490–494. doi: 10.1002/bjs.1800620615. [DOI] [PubMed] [Google Scholar]
  8. Kierulf P., Godal H. C. Fibrinemia in medical patients screened by the ethanol test. Acta Med Scand. 1971 Sep;190(3):185–190. doi: 10.1111/j.0954-6820.1971.tb07414.x. [DOI] [PubMed] [Google Scholar]
  9. Kwaan H. C., Anderson M. C., Gramatica L. A study of pancreatic enzymes as a factor in the pathogenesis of disseminated intravascular coagulation during acute pancreatitis. Surgery. 1971 May;69(5):663–672. [PubMed] [Google Scholar]
  10. Malleson P. N. Letter: Abnormal coagulation and trauma. Lancet. 1974 Dec 7;2(7893):1395–1395. doi: 10.1016/s0140-6736(74)92274-0. [DOI] [PubMed] [Google Scholar]
  11. Merskey C., Kleiner G. J., Johnson A. J. Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966 Jul;28(1):1–18. [PubMed] [Google Scholar]
  12. Mungall I. P., Hague R. V. Pancreatitis and the pill. Postgrad Med J. 1975 Dec;51(602):855–857. doi: 10.1136/pgmj.51.602.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Owen C. A., Jr, Bowie E. J. Chronic intravascular coagulation syndromes. A summary. Mayo Clin Proc. 1974 Sep;49(9):673–679. [PubMed] [Google Scholar]
  14. SHINOWARA G. Y., STUTMAN L. J., WALTERS M. I., RUTH M. E., WALKER E. J. Hypercoagulability in acute pancreatitis. Am J Surg. 1963 Jun;105:714–719. doi: 10.1016/0002-9610(63)90483-5. [DOI] [PubMed] [Google Scholar]
  15. THAL A. P., PERRY J. F., Jr, EGNER W. A clinical and morphologic study of forty-two cases of fatal acute pancreatitis. Surg Gynecol Obstet. 1957 Aug;105(2):191–202. [PubMed] [Google Scholar]
  16. Trapnell J. E. The natural history and prognosis of acute pancreatitis. Ann R Coll Surg Engl. 1966 May;38(5):265–287. [PMC free article] [PubMed] [Google Scholar]
  17. Warshaw A. L., Imbembo A. L., Civetta J. M., Daggett W. M. Surgical intervention in acute necrotizing pancreatitis. Am J Surg. 1974 Apr;127(4):484–491. doi: 10.1016/0002-9610(74)90301-8. [DOI] [PubMed] [Google Scholar]
  18. Yoshikawa T., Tanaka K. R., Guze L. B. Infection and disseminated intravascular coagulation. Medicine (Baltimore) 1971 Jul;50(4):237–258. doi: 10.1097/00005792-197107000-00001. [DOI] [PubMed] [Google Scholar]

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