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. 1969 Feb;97(2):848–860. doi: 10.1128/jb.97.2.848-860.1969

Chromosome Replication in Salmonella typhimurium1

Hilary Chan a, Karl G Lark a
PMCID: PMC249769  PMID: 4886297

Abstract

The replication of the Salmonella typhimurium chromosome was studied. As with E. coli 15T−, replication was sequential. After amino acid starvation, replication proceeded from a unique and heritable region of the chromosome. 5-Bromouracil, when substituted for thymine, did not disturb the sequence of replication nor did it initiate extra replication cycles. By labeling the origin and the terminus of the chromosome with 3H- and 14C-thymine, respectively, it was possible to determine that the rate of chain elongation decreases as the growth rate decreases. No gap in the replication cycle could be observed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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