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. 1969 Jul;99(1):8–12. doi: 10.1128/jb.99.1.8-12.1969

Immunological Response of Three Mouse Strains to Typhoid Vaccine and Vi Antigen

Vito M Esposito 1, John C Feeley 1, Wayne D Leeder 1, Margaret Pittman 1
PMCID: PMC249959  PMID: 5802620

Abstract

Vi-agglutinin, active cutaneous anaphylaxis and protective responses (ed50) of three mouse strains (CFW, NIH, and Balb/cAnN) to acetone-inactivated typhoid vaccine and soluble Vi antigen were compared. Seven days after immunization with either typhoid vaccine or Vi antigen the three strains of mice differed with respect to Vi-antibody titers. Significant differences were observed in the protective responses. Each mouse strain was significantly better protected by the intraperitoneal than by subcutaneous route of immunization. Active cutaneous anaphylaxis was more pronounced in showing strain differences in response to Vi antigen. The serological responses to Vi antigen of the strains of mice did not correlate with their protective response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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