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. 1991 Nov;65(11):6260–6265. doi: 10.1128/jvi.65.11.6260-6265.1991

Human herpesvirus 7: antigenic properties and prevalence in children and adults.

L S Wyatt 1, W J Rodriguez 1, N Balachandran 1, N Frenkel 1
PMCID: PMC250327  PMID: 1656093

Abstract

The recent isolation of human herpesvirus 7 (HHV-7) from activated CD4+ T lymphocytes of a healthy individual raises questions regarding the prevalence of this virus in humans and its immunological relationship to previously characterized human herpesviruses. We report that HHV-7 is a ubiquitous virus which is immunologically distinct from the highly prevalent T-lymphotropic HHV-6. Thus, (i) only two of six monoclonal antibodies to HHV-6 cross-reacted with HHV-7-infected cells, (ii) Western immunoblot analyses of viral proteins revealed different patterns for HHV-6- and HHV-7-infected cells, (iii) tests of sequential serum samples from children revealed seroconversion to HHV-6 without concomitant seroconversion to HHV-7, and (iv) in some instances HHV-7 infection occurred in the presence of high titers of HHV-6 antibodies, suggesting the lack of apparent protection of children seropositive for HHV-6 against subsequent infection with HHV-7. On the basis of the analyses of sera from children and adults it can be concluded that HHV-7 is a prevalent human herpesvirus which, like other human herpesviruses, infects during childhood. The age of infection appears to be somewhat later than the very early age documented for HHV-6.

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Selected References

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  1. Balachandra K., Ayuthaya P. I., Auwanit W., Jayavasu C., Okuno T., Yamanishi K., Takahashi M. Prevalence of antibody to human herpesvirus 6 in women and children. Microbiol Immunol. 1989;33(6):515–518. doi: 10.1111/j.1348-0421.1989.tb02001.x. [DOI] [PubMed] [Google Scholar]
  2. Balachandran N., Amelse R. E., Zhou W. W., Chang C. K. Identification of proteins specific for human herpesvirus 6-infected human T cells. J Virol. 1989 Jun;63(6):2835–2840. doi: 10.1128/jvi.63.6.2835-2840.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Briggs M., Fox J., Tedder R. S. Age prevalence of antibody to human herpesvirus 6. Lancet. 1988 May 7;1(8593):1058–1059. doi: 10.1016/s0140-6736(88)91883-1. [DOI] [PubMed] [Google Scholar]
  4. Di Luca D., Katsafanas G., Schirmer E. C., Balachandran N., Frenkel N. The replication of viral and cellular DNA in human herpesvirus 6-infected cells. Virology. 1990 Mar;175(1):199–210. doi: 10.1016/0042-6822(90)90200-b. [DOI] [PubMed] [Google Scholar]
  5. Downing R. G., Sewankambo N., Serwadda D., Honess R., Crawford D., Jarrett R., Griffin B. E. Isolation of human lymphotropic herpesviruses from Uganda. Lancet. 1987 Aug 15;2(8555):390–390. doi: 10.1016/s0140-6736(87)92403-2. [DOI] [PubMed] [Google Scholar]
  6. Frenkel N., Schirmer E. C., Wyatt L. S., Katsafanas G., Roffman E., Danovich R. M., June C. H. Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci U S A. 1990 Jan;87(2):748–752. doi: 10.1073/pnas.87.2.748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Levy J. A., Ferro F., Greenspan D., Lennette E. T. Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population. Lancet. 1990 May 5;335(8697):1047–1050. doi: 10.1016/0140-6736(90)92628-u. [DOI] [PubMed] [Google Scholar]
  8. Lopez C., Pellett P., Stewart J., Goldsmith C., Sanderlin K., Black J., Warfield D., Feorino P. Characteristics of human herpesvirus-6. J Infect Dis. 1988 Jun;157(6):1271–1273. doi: 10.1093/infdis/157.6.1271. [DOI] [PubMed] [Google Scholar]
  9. Okuno T., Takahashi K., Balachandra K., Shiraki K., Yamanishi K., Takahashi M., Baba K. Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol. 1989 Apr;27(4):651–653. doi: 10.1128/jcm.27.4.651-653.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  11. Saxinger C., Polesky H., Eby N., Grufferman S., Murphy R., Tegtmeir G., Parekh V., Memon S., Hung C. Antibody reactivity with HBLV (HHV-6) in U.S. populations. J Virol Methods. 1988 Sep;21(1-4):199–208. doi: 10.1016/0166-0934(88)90066-3. [DOI] [PubMed] [Google Scholar]
  12. Schirmer E. C., Wyatt L. S., Yamanishi K., Rodriguez W. J., Frenkel N. Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5922–5926. doi: 10.1073/pnas.88.13.5922. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Suga S., Yoshikawa T., Asano Y., Yazaki T., Ozaki T. Neutralizing antibody assay for human herpesvirus-6. J Med Virol. 1990 Jan;30(1):14–19. doi: 10.1002/jmv.1890300104. [DOI] [PubMed] [Google Scholar]
  14. Tedder R. S., Briggs M., Cameron C. H., Honess R., Robertson D., Whittle H. A novel lymphotropic herpesvirus. Lancet. 1987 Aug 15;2(8555):390–392. doi: 10.1016/s0140-6736(87)92404-4. [DOI] [PubMed] [Google Scholar]
  15. Ueda K., Kusuhara K., Hirose M., Okada K., Miyazaki C., Tokugawa K., Nakayama M., Yamanishi K. Exanthem subitum and antibody to human herpesvirus-6. J Infect Dis. 1989 Apr;159(4):750–752. doi: 10.1093/infdis/159.4.750. [DOI] [PubMed] [Google Scholar]
  16. Wyatt L. S., Balachandran N., Frenkel N. Variations in the replication and antigenic properties of human herpesvirus 6 strains. J Infect Dis. 1990 Oct;162(4):852–857. doi: 10.1093/infdis/162.4.852. [DOI] [PubMed] [Google Scholar]
  17. Yamamoto M., Black J. B., Stewart J. A., Lopez C., Pellett P. E. Identification of a nucleocapsid protein as a specific serological marker of human herpesvirus 6 infection. J Clin Microbiol. 1990 Sep;28(9):1957–1962. doi: 10.1128/jcm.28.9.1957-1962.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. doi: 10.1016/s0140-6736(88)91893-4. [DOI] [PubMed] [Google Scholar]
  19. Yoshikawa T., Suga S., Asano Y., Yazaki T., Kodama H., Ozaki T. Distribution of antibodies to a causative agent of exanthem subitum (human herpesvirus-6) in healthy individuals. Pediatrics. 1989 Oct;84(4):675–677. [PubMed] [Google Scholar]
  20. Yoshikawa T., Suga S., Asano Y., Yazaki T., Ozaki T. Neutralizing antibodies to human herpesvirus-6 in healthy individuals. Pediatr Infect Dis J. 1990 Aug;9(8):589–590. doi: 10.1097/00006454-199008000-00013. [DOI] [PubMed] [Google Scholar]

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