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. 1989 Sep;63(9):4043–4046. doi: 10.1128/jvi.63.9.4043-4046.1989

An amplified endogenous retroviral sequence on the murine Y chromosome related to murine leukemia viruses and viruslike 30S sequences.

K W Hutchison 1, E M Eicher 1
PMCID: PMC251003  PMID: 2548014

Abstract

A highly repeated sequence on the murine Y chromosome was cloned and characterized. The DNA sequence of the viral long terminal repeats (LTRs) showed that the 5' and 3' LTRs were approximately 90% homologous. The LTRs are generally unrelated to any previously reported viral LTR but are somewhat similar to the viruslike 30S sequences.

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Selected References

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  1. Cohen J. C., Varmus H. E. Endogenous mammary tumour virus DNA varies among wild mice and segregates during inbreeding. Nature. 1979 Mar 29;278(5703):418–423. doi: 10.1038/278418a0. [DOI] [PubMed] [Google Scholar]
  2. Eicher E. M., Hutchison K. W., Phillips S. J., Tucker P. K., Lee B. K. A repeated segment on the mouse Y chromosome is composed of retroviral-related, Y-enriched and Y-specific sequences. Genetics. 1989 May;122(1):181–192. doi: 10.1093/genetics/122.1.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Giri C. P., Hodgson C. P., Elder P. K., Courtney M. G., Getz M. J. Discrete regions of sequence homology between cloned rodent VL30 genetic elements and AKV-related MuLV provirus genomes. Nucleic Acids Res. 1983 Jan 25;11(2):305–319. doi: 10.1093/nar/11.2.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Groner B., Hynes N. E. Number and location of mouse mammary tumor virus proviral DNA in mouse DNA of normal tissue and of mammary tumors. J Virol. 1980 Mar;33(3):1013–1025. doi: 10.1128/jvi.33.3.1013-1025.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Herr W. Nucleotide sequence of AKV murine leukemia virus. J Virol. 1984 Feb;49(2):471–478. doi: 10.1128/jvi.49.2.471-478.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hodgson C. P., Elder P. K., Ono T., Foster D. N., Getz M. J. Structure and expression of mouse VL30 genes. Mol Cell Biol. 1983 Dec;3(12):2221–2231. doi: 10.1128/mcb.3.12.2221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoggan M. D., Buckler C. E., Sears J. F., Rowe W. P., Martin M. A. Organization and stability of endogenous xenotropic murine leukemia virus proviral DNA in mouse genomes. J Virol. 1983 Jan;45(1):473–477. doi: 10.1128/jvi.45.1.473-477.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hutchison K. W., Copeland N. G., Jenkins N. A. Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles. Mol Cell Biol. 1984 Dec;4(12):2899–2904. doi: 10.1128/mcb.4.12.2899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Itin A., Keshet E. A novel retroviruslike family in mouse DNA. J Virol. 1986 Aug;59(2):301–307. doi: 10.1128/jvi.59.2.301-307.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Itin A., Keshet E. Diverse long terminal repeats are associated with murine retroviruslike (VL30) elements. Mol Cell Biol. 1986 Apr;6(4):1276–1282. doi: 10.1128/mcb.6.4.1276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Itin A., Keshet E. Nucleotide sequence analysis of the long terminal repeat of murine virus-like DNA (VL30) and its adjacent sequences: resemblance to retrovirus proviruses. J Virol. 1983 Sep;47(3):656–659. doi: 10.1128/jvi.47.3.656-659.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Keshet E., Itin A. Patterns of genomic distribution and sequence heterogeneity of a murine "retrovirus-like" multigene family. J Virol. 1982 Jul;43(1):50–58. doi: 10.1128/jvi.43.1.50-58.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lueders K. K., Kuff E. L. Sequences associated with intracisternal A particles are reiterated in the mouse genome. Cell. 1977 Dec;12(4):963–972. doi: 10.1016/0092-8674(77)90161-1. [DOI] [PubMed] [Google Scholar]
  14. MacInnes J. I., Morris V. L., Flintoff W. F., Kozak C. A. Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice. Virology. 1984 Jan 15;132(1):12–25. doi: 10.1016/0042-6822(84)90087-4. [DOI] [PubMed] [Google Scholar]
  15. Norton J. D., Connor J., Avery R. J. Unusual long terminal repeat sequence of a retrovirus transmissible mouse (VL 30) genetic element: identification of functional domains. Nucleic Acids Res. 1984 Apr 25;12(8):3445–3460. doi: 10.1093/nar/12.8.3445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pampeno C. L., Meruelo D. Isolation of a retroviruslike sequence from the TL locus of the C57BL/10 murine major histocompatibility complex. J Virol. 1986 May;58(2):296–306. doi: 10.1128/jvi.58.2.296-306.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Phillips S. J., Birkenmeier E. H., Callahan R., Eicher E. M. Male and female mouse DNAs can be discriminated using retroviral probes. Nature. 1982 May 20;297(5863):241–243. doi: 10.1038/297241a0. [DOI] [PubMed] [Google Scholar]
  18. Rotman G., Itin A., Keshet E. 'Solo' large terminal repeats (LTR) of an endogenous retrovirus-like gene family (VL30) in the mouse genome. Nucleic Acids Res. 1984 Mar 12;12(5):2273–2282. doi: 10.1093/nar/12.5.2273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sonigo P., Wain-Hobson S., Bougueleret L., Tiollais P., Jacob F., Brûlet P. Nucleotide sequence and evolution of ETn elements. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3768–3771. doi: 10.1073/pnas.84.11.3768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stavenhagen J. B., Robins D. M. An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene. Cell. 1988 Oct 21;55(2):247–254. doi: 10.1016/0092-8674(88)90047-5. [DOI] [PubMed] [Google Scholar]
  21. Stoye J. P., Coffin J. M. Polymorphism of murine endogenous proviruses revealed by using virus class-specific oligonucleotide probes. J Virol. 1988 Jan;62(1):168–175. doi: 10.1128/jvi.62.1.168-175.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Takahata N., Kimura M. A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes. Genetics. 1981 Jul;98(3):641–657. doi: 10.1093/genetics/98.3.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wirth T., Glöggler K., Baumruker T., Schmidt M., Horak I. Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3327–3330. doi: 10.1073/pnas.80.11.3327. [DOI] [PMC free article] [PubMed] [Google Scholar]

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