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. 1972 Sep;111(3):739–744. doi: 10.1128/jb.111.3.739-744.1972

Regulation of Histidyl-Transfer Ribonucleic Acid Synthetase Formation in a Histidyl-Transfer Ribonucleic Acid Synthetase Mutant of Salmonella typhimurium

E McGinnis 1, L S Williams 1
PMCID: PMC251347  PMID: 4559825

Abstract

Control of formation of the histidyl-transfer ribonucleic acid (tRNA) synthetase with an increased Km for histidine was studied in a hisS mutant of Salmonella typhimurium. Histidine restriction of both the hisS and hisS+ strains resulted in a derepression of synthesis of histidyl-tRNA synthetase. When grown in a concentration less than the Km (100 μg/ml) of l-histidine, the hisS mutant maintained a higher level of histidyl-tRNA synthetase than the hisS+ strain. Addition of excess amounts of l-histidine to the growth medium of the hisS mutant culture grown with 100 μg of l-histidine per ml resulted in a repression of histidyl-tRNA synthetase formation to equal that of the hisS+ strain grown in 100 μg of l-histidine per ml. These data confirm previous findings that histidine tRNA is involved in the repression of synthesis of histidyl-tRNA synthetase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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