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. 1972 Sep;111(3):778–783. doi: 10.1128/jb.111.3.778-783.1972

Methionine Adenosyltransferase and Ethionine Resistance in Saccharomyces cerevisiae

Janet E Mertz 1, K D Spence 1
PMCID: PMC251352  PMID: 4559828

Abstract

The methionine adenosyltransferase is repressed in Saccharomyces cerevisiae during growth in the presence of excess methionine. The relationship of this repression to the level of intracellular S-adenosylmethionine is discussed. In conjunction with these studies, an ethionine-resistant mutant has been investigated which has a low level of methionine adenosyltransferase under all conditions tested. The mechanism of ethionine resistance in the latter strain apparently depends on its inability to form large quantities of intracellular S-adenosylethionine. With respect to the methionine adenosyltransferase, there is no apparent interaction between ethionine-resistant and ethionine-sensitive alleles when both are present in the heterozygous diploid.

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Selected References

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