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. 1972 Oct;112(1):200–205. doi: 10.1128/jb.112.1.200-205.1972

Klebsiella aerogenes Strain Carrying Drug-Resistance Determinants and a lac Plasmid

Jean E Brenchley a,1, Boris Magasanik a
PMCID: PMC251397  PMID: 4342813

Abstract

In addition to carrying determinants conferring resistance to at least two antibiotics, chloramphenicol and streptomycin, a Klebsiella aerogenes strain contains a plasmid responsible for increased β-galactosidase activity. The plasmid can be transferred to Escherichia coli and Salmonella typhimurium strains. K. aerogenes segregants without the plasmid grow on lactose one-half as fast as the parent strain and contain only one-tenth to one-fifth as much β-galactosidase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. S. The ecology of transferable drug resistance in the enterobacteria. Annu Rev Microbiol. 1968;22:131–180. doi: 10.1146/annurev.mi.22.100168.001023. [DOI] [PubMed] [Google Scholar]
  2. Bouanchaud D. H., Scavizzi M. R., Chabbert Y. A. Elimination by ethidium bromide of antibiotic resistance in enterobacteria and staphylococci. J Gen Microbiol. 1968 Dec;54(3):417–425. doi: 10.1099/00221287-54-3-417. [DOI] [PubMed] [Google Scholar]
  3. FALKOW S., WOHLHIETER J. A., CITARELLA R. V., BARON L. S. TRANSFER OF EPISOMIC ELEMENTS TO PROTEUS. II. NATURE OF LAC+ PROTEUS STRAINS ISOLATED FROM CLINICAL SPECIMENS. J Bacteriol. 1964 Dec;88:1598–1601. doi: 10.1128/jb.88.6.1598-1601.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Falkow S., Baron L. S. EPISOMIC ELEMENT IN A STRAIN OF SALMONELLA TYPHOSA. J Bacteriol. 1962 Sep;84(3):581–589. doi: 10.1128/jb.84.3.581-589.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hirota Y. THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1960 Jan;46(1):57–64. doi: 10.1073/pnas.46.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Iyer R. V., Iyer V. N. Genetic and molecular properties of an infectious antibiotic resistance (R) factor isolated from Klebsiella. J Bacteriol. 1969 Nov;100(2):605–616. doi: 10.1128/jb.100.2.605-616.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MacPhee D. G., Sutherland I. W., Wilkinson J. F. Transduction in Klebsiella. Nature. 1969 Feb 1;221(5179):475–476. doi: 10.1038/221475a0. [DOI] [PubMed] [Google Scholar]
  8. Novick R. P. Extrachromosomal inheritance in bacteria. Bacteriol Rev. 1969 Jun;33(2):210–263. doi: 10.1128/br.33.2.210-263.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Prival M. J., Magasanik B. Resistance to catabolite repression of histidase and proline oxidase during nitrogen-limited growth of Klebsiella aerogenes. J Biol Chem. 1971 Oct 25;246(20):6288–6296. [PubMed] [Google Scholar]
  10. Reeve E. C., Braithwaite J. A. Fk-lac, an episome with unusual properties found in a wild strain of a Klebsiella species. Nature. 1970 Oct 10;228(5267):162–164. doi: 10.1038/228162a0. [DOI] [PubMed] [Google Scholar]
  11. Reeve E. C. Transfer characteristics of two resistance determinants in a wild strain of Klebsiella aerogenes (V9A). Genet Res. 1970 Oct 2;16(2):235–240. doi: 10.1017/s0016672300002470. [DOI] [PubMed] [Google Scholar]
  12. SUTTER V. L., FOECKING F. J. Biochemical characteristics of lactose-fermenting Proteus rettgeri from clinical specimens. J Bacteriol. 1962 Apr;83:933–935. doi: 10.1128/jb.83.4.933-935.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Smith G. R., Halpern Y. S., Magasanik B. Genetic and metabolic control of enzymes responsible for histidine degradation in Salmonella typhimurium. 4-imidazolone-5-propionate amidohydrolase and N-formimino-L-glutamate formiminohydrolase. J Biol Chem. 1971 May 25;246(10):3320–3329. [PubMed] [Google Scholar]
  14. Tomoeda M., Inuzuka M., Kubo N., Nakamura S. Effective elimination of drug resistance and sex factors in Escherichia coli by sodium dodecyl sulfate. J Bacteriol. 1968 Mar;95(3):1078–1089. doi: 10.1128/jb.95.3.1078-1089.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WATANABE T., FUKASAWA T. Episome-mediated transfer of drug resistance in Enterobacteriaceae IV. Interactions between resistance transfer factor and F-factor in Escherichia coli K-12. J Bacteriol. 1962 Apr;83:727–735. doi: 10.1128/jb.83.4.727-735.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]

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