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. 1972 Nov;112(2):950–958. doi: 10.1128/jb.112.2.950-958.1972

Cell Wall Peptidoglycan Mutants of Escherichia coli K-12: Existence of Two Clusters of Genes, mra and mrb, for Cell Wall Peptidoglycan Biosynthesis

Tokichi Miyakawa a, Hiroshi Matsuzawa a,1, Michio Matsuhashi a, Yoshinobu Sugino a,2
PMCID: PMC251507  PMID: 4563986

Abstract

Temperature-sensitive mutants of Escherichia coli K-12 which cannot form cell wall peptidoglycan at 42 C were isolated. The thermosensitive steps were characterized biochemically, and the genes coding the enzymes of peptidoglycan synthesis were mapped. These genes were in two clusters: one group, located at about 1.5 min between leu and azi, was designated as mra (murein a); the second group, located at about 77.5 min close to argH and metB, was designated as mrb (murein b, with the order metB-argH-mrb). No simple relations were found between the gene location and the order or localization of enzymes involved in the sequence of reactions of cell wall peptidoglycan biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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