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. 1973 Mar;113(3):1156–1160. doi: 10.1128/jb.113.3.1156-1160.1973

Relationship Between Methionyl Transfer Ribonucleic Acid Cellular Content and Synthesis of Methionine Enzymes in Saccharomyces cerevisiae

Y Surdin-Kerjan 1, H Cherest 1, H de Robichon-Szulmajster 1
PMCID: PMC251676  PMID: 4570771

Abstract

Derepression of some methionine biosynthetic enzymes (methionine group I enzymes) obtained in methionine limitation has been found to be accompanied by a significant lack of in vivo charging of bulk methionine transfer ribonucleic acid (tRNAMet) and in addition by a decreased rate of synthesis of all tRNAs. Under the same conditions, methionyl-tRNA synthetase (MTS) was derepressed rather than repressed. These results are in agreement with those previously published based on studies of a mutant with an impaired MTS (5) and reinforce the idea that the rate of synthesis of methionine group I enzymes can be related to the total content of methionyl (Met)-tRNA Met per cell. They also render unlikely that MTS could be a constituent of the regulatory signal.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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