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. 1967 Sep;94(3):600–608. doi: 10.1128/jb.94.3.600-608.1967

In Vivo Growth and Distribution of Anthrax Bacilli in Resistant, Susceptible, and Immunized Hosts

William I Jones Jr 1, Frederick Klein 1, Jerry S Walker 1, Bill G Mahlandt 1, James P Dobbs 1, Ralph E Lincoln 1
PMCID: PMC251930  PMID: 6068144

Abstract

Differences in in vivo growth rates of Bacillus anthracis in the bodies of infected rats and guinea pigs showed the effect of innate species resistance. The effect of two levels of immunity imposed on these hosts demonstrated that, as the degree of immunity increased, the growth rate of organisms decreased and was accompanied by a decrease in terminal population. It was shown that growth rates in the blood best reflected the population growth in the entire host. Data obtained from the naturally resistant rat that had been immunized with both the Belton-Strange protective antigen and live vaccine demonstrated the role of “toxins” in terminal anthrax. The in vivo morphological changes in anthrax bacilli pointed out errors regarding estimates of true terminal population of organisms when samples for counting were taken postmortem rather than at the time of death.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DEARMON I. A., Jr, KLEIN F., LINCOLN R. E., MAHLANDT B. G., FERNELIUS A. L. Immunological studies of anthrax. I. An index to determine quantitative immunization. J Immunol. 1961 Sep;87:233–239. [PubMed] [Google Scholar]
  2. HAINES B. W., KLEIN F., LINCOLN R. E. QUANTITATIVE ASSAY FOR CRUDE ANTHRAX TOXINS. J Bacteriol. 1965 Jan;89:74–83. doi: 10.1128/jb.89.1.74-83.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. KEPPIE J., SMITH H., HARRIS-SMITH P. W. The chemical basis of the virulence of Bacillus anthracis. III. The role of the terminal bacteraemia in death of guinea-pigs from anthrax. Br J Exp Pathol. 1955 Jun;36(3):315–322. [PMC free article] [PubMed] [Google Scholar]
  4. KLEIN F., DEARMON I. A., Jr, LINCOLN R. E., MAHLANDT B. G., FERNELIUS A. L. Immunological studies of anthrox. II. Levels of immunity against Bacillus anthracis obtained with protective antigen and live vaccine. J Immunol. 1962 Jan;88:15–19. [PubMed] [Google Scholar]
  5. KLEIN F., HAINES B. W., MAHLANDT B. G., DEARMON I. A., Jr, LINCOLN R. E. DUAL NATURE OF RESISTANCE MECHANISMS AS REVEALED BY STUDIES OF ANTHRAX SEPTICEMIA. J Bacteriol. 1963 May;85:1032–1038. doi: 10.1128/jb.85.5.1032-1038.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KLEIN F., MAHLANDT B. G., LINCOLN R. E., DEARMON I. A., Jr, FERNELIUS A. L. Immunization as a factor affecting the course of septicemic anthrax. Science. 1961 Mar 31;133(3457):1021–1022. doi: 10.1126/science.133.3457.1021. [DOI] [PubMed] [Google Scholar]
  7. Mahlandt B. G., Klein F., Lincoln R. E., Haines B. W., Jones W. I., Jr, Friedman R. H. Immunologic studies of anthrax. IV. Evaluation of the immunogenicity of three components of anthrax toxin. J Immunol. 1966 Apr;96(4):727–733. doi: 10.21236/ad0640357. [DOI] [PubMed] [Google Scholar]
  8. RHIAN M., RILEY J. M., WOLFE V. L., SIMMONS A. H. Change in virulence of Bacillus anthracis spores as affected by solids and challenge route. J Infect Dis. 1963 Mar-Apr;112:187–193. doi: 10.1093/infdis/112.2.187. [DOI] [PubMed] [Google Scholar]
  9. WARD M. K., MCGANN V. G., HOGGE A. L., Jr, HUFF M. L., KANODE R. G., Jr, ROBERTS E. O. STUDIES ON ANTHRAX INFECTIONS IN IMMUNIZED GUINEA PIGS. J Infect Dis. 1965 Feb;115:59–67. doi: 10.1093/infdis/115.1.59. [DOI] [PubMed] [Google Scholar]

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