Abstract
A recombination-deficient (Rec−) ultraviolet-sensitive mutant of Salmonella typhimurium was isolated. The mutant grows more slowly than the wild-type strain and degrades its deoxyribonucleic acid extensively both during normal growth and after ultraviolet irradiation. Evidence is presented that a growing Rec− population consists of two types of cells, one which can divide and one which cannot.
Full text
PDF![1828](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/5885913499cb/jbacter00402-0368.png)
![1829](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/bd150d3a9f7e/jbacter00402-0369.png)
![1830](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/0f9913313c20/jbacter00402-0370.png)
![1831](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/791a2f7d0682/jbacter00402-0371.png)
![1832](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/59799e75904c/jbacter00402-0372.png)
![1833](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/bbe78b6d4583/jbacter00402-0373.png)
![1834](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af6f/252217/15edc2150362/jbacter00402-0374.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CLARK A. J., MARGULIES A. D. ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12. Proc Natl Acad Sci U S A. 1965 Feb;53:451–459. doi: 10.1073/pnas.53.2.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark A. J., Chamberlin M., Boyce R. P., Howard-Flanders P. Abnormal metabolic response to ultraviolet light of a recombination deficient mutant of Escherichia coli K12. J Mol Biol. 1966 Aug;19(2):442–454. doi: 10.1016/s0022-2836(66)80015-3. [DOI] [PubMed] [Google Scholar]
- Gellert M. Formation of covalent circles of lambda DNA by E. coli extracts. Proc Natl Acad Sci U S A. 1967 Jan;57(1):148–155. doi: 10.1073/pnas.57.1.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howard-Flanders P., Boyce R. P. DNA repair and genetic recombination: studies on mutants of Escherichia coli defective in these processes. Radiat Res. 1966;(Suppl):156+–156+. [PubMed] [Google Scholar]
- Howard-Flanders P., Theriot L. Mutants of Escherichia coli K-12 defective in DNA repair and in genetic recombination. Genetics. 1966 Jun;53(6):1137–1150. doi: 10.1093/genetics/53.6.1137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JACOB F., WOLLMAN E. Induction spontanée du développement du bactériophage lambda au cours de la recombinaison génétique, chez Escherichia coli K 12. C R Hebd Seances Acad Sci. 1954 Jul 19;239(3):317–319. [PubMed] [Google Scholar]
- LEVINE M., BORTHWICK M. THE ACTION OF STREPTONIGRIN ON BACTERIAL DNA METABOLISM AND ON INDUCTION OF PHAGE PRODUCTION IN LYSOGENIC BACTERIA. Virology. 1963 Dec;21:568–574. doi: 10.1016/0042-6822(63)90228-9. [DOI] [PubMed] [Google Scholar]
- SANDERSON K. E., DEMEREC M. THE LINKAGE MAP OF SALMONELLA TYPHIMURIUM. Genetics. 1965 Jun;51:897–913. doi: 10.1093/genetics/51.6.897. [DOI] [PMC free article] [PubMed] [Google Scholar]