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. 1985 Oct;56(1):60–65. doi: 10.1128/jvi.56.1.60-65.1985

Herpesvirus sylvilagus infects both B and T lymphocytes in vivo.

W J Kramp, P Medveczky, C Mulder, H C Hinze, J L Sullivan
PMCID: PMC252470  PMID: 2993667

Abstract

Herpesvirus sylvilagus infection of cottontail rabbits (Sylvilagus floridanus) was studied as a model of herpesvirus-induced lymphoproliferative disorders. Leukocytosis, splenomegaly, proliferation of T cells and virus production by lymphocytes characterized this infectious mononucleosis-like disease. Approximately two copies of circular herpesvirus sylvilagus genomes per cell were detected in spleen cells at 2 weeks postinfection, and circular genomes could still be observed after 4 months. Circular viral genomes were found in both B and T lymphocytes. Small amounts of linear viral DNA (0.1 to 0.3 copies per cell) were also detected in both B and T cells. These results indicated that the virus did not replicate in the majority of lymphocytes in vivo. Herpesvirus sylvilagus infection in cottontail rabbits could be useful as a model for studying the complex virus-host relationships of lymphotropic herpesviruses and perhaps as an animal model for Epstein-Barr virus infection in humans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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