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. 1986 Feb;57(2):706–708. doi: 10.1128/jvi.57.2.706-708.1986

T-cell-deficient mice display normal recovery from experimental rotavirus infection.

J Eiden, H M Lederman, S Vonderfecht, R Yolken
PMCID: PMC252790  PMID: 3484788

Abstract

Rotaviruses are common causes of diarrhea in animals and humans. Little is known, however, about the components of the host response to these viruses. Rotavirus infection was studied in athymic mice experimentally infected with murine rotavirus. Neonatal T-cell-deficient mice experienced a self-limited gastrointestinal infection which was identical to that observed in age-matched immunocompetent mice. Adult T-cell-deficient seronegative mice and age-matched normal mice showed a similar extent of resistance to symptomatic rotavirus infection. In both cases, the infection was resolved without the generation of antirotavirus antibody. These studies indicate that host defense against murine rotavirus requires neither functional T-lymphocytes nor specific antiviral antibody.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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