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. 1995 Nov;73(3):F166–F169. doi: 10.1136/fn.73.3.f166

Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations.

J M Hawdon 1, M Hubbard 1, C N Hales 1, P M Clark 1
PMCID: PMC2528460  PMID: 8535874

Abstract

Highly specific immunoradiometric assays were used to measure plasma concentrations of insulin, proinsulin, and 32-33 split proinsulin in neonates (n = 16). Neonatal plasma insulin concentrations were high relative to blood glucose concentrations and compared with adult insulin-glucose relations. Concentrations of proinsulin and 32-33 split proinsulin together accounted for 34-70% of the total concentration of insulin and pro-peptides. This study confirms the need to use a specific assay and neonatal reference data in the diagnosis of neonatal hyperinsulinism, and shows that neonatal pancreatic beta cell function may differ from that of older subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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