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. 1986 Apr;58(1):220–222. doi: 10.1128/jvi.58.1.220-222.1986

Monoclonal antibodies against the fusion protein are protective in necrotizing mumps meningoencephalitis.

A Löve, R Rydbeck, G Utter, C Orvell, K Kristensson, E Norrby
PMCID: PMC252897  PMID: 3754016

Abstract

A monoclonal antibody against the fusion (F) protein of mumps virus was found to confer marked protection in mumps virus-induced encephalitis. Almost total prevention of extensive brain necrosis was found. This study indicates that the virus F protein is directly involved in the pathogenesis of brain necrosis.

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Selected References

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  1. Buchmeier M. J., Lewicki H. A., Talbot P. J., Knobler R. L. Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody. Virology. 1984 Jan 30;132(2):261–270. doi: 10.1016/0042-6822(84)90033-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Choppin P. W., Scheid A. The role of viral glycoproteins in adsorption, penetration, and pathogenicity of viruses. Rev Infect Dis. 1980 Jan-Feb;2(1):40–61. doi: 10.1093/clinids/2.1.40. [DOI] [PubMed] [Google Scholar]
  3. Johnson R. T., Johnson K. P. Hydrocephalus following viral infection: the pathology of aqueductal stenosis developing after experimental mumps virus infection. J Neuropathol Exp Neurol. 1968 Oct;27(4):591–606. [PubMed] [Google Scholar]
  4. Kristensson K., Leestma J., Lundh B., Norrby E. Sendai virus infection in the mouse brain: virus spread and long-term effects. Acta Neuropathol. 1984;63(2):89–95. doi: 10.1007/BF00697190. [DOI] [PubMed] [Google Scholar]
  5. Lefrancois L. Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo. J Virol. 1984 Jul;51(1):208–214. doi: 10.1128/jvi.51.1.208-214.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Liddell F. D. Evaluation of survival in challenge experiments. Microbiol Rev. 1978 Mar;42(1):237–249. doi: 10.1128/mr.42.1.237-249.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Löve A., Rydbeck R., Kristensson K., Orvell C., Norrby E. Hemagglutinin-neuraminidase glycoprotein as a determinant of pathogenicity in mumps virus hamster encephalitis: analysis of mutants selected with monoclonal antibodies. J Virol. 1985 Jan;53(1):67–74. doi: 10.1128/jvi.53.1.67-74.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McCarthy M., Jubelt B., Fay D. B., Johnson R. T. Comparative studies of five strains of mumps virus in vitro and in neonatal hamsters: evaluation of growth, cytopathogenicity, and neurovirulence. J Med Virol. 1980;5(1):1–15. doi: 10.1002/jmv.1890050102. [DOI] [PubMed] [Google Scholar]
  9. Merz D. C., Wolinsky J. S. Conversion of nonfusing mumps virus infections to fusing infections by selective proteolysis of the HN glycoprotein. Virology. 1983 Dec;131(2):328–340. doi: 10.1016/0042-6822(83)90501-9. [DOI] [PubMed] [Google Scholar]
  10. Norrby E., Gollmar Y. Identification of measles virus-specific hemolysis-inihibiting antibodies separate from hemagglutination-inhibiting antibodies. Infect Immun. 1975 Feb;11(2):231–239. doi: 10.1128/iai.11.2.231-239.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Orvell C., Grandien M. The effects of monoclonal antibodies on biologic activities of structural proteins of Sendai virus. J Immunol. 1982 Dec;129(6):2779–2787. [PubMed] [Google Scholar]
  12. Orvell C. The reactions of monoclonal antibodies with structural proteins of mumps virus. J Immunol. 1984 May;132(5):2622–2629. [PubMed] [Google Scholar]
  13. Parham P. On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice. J Immunol. 1983 Dec;131(6):2895–2902. [PubMed] [Google Scholar]
  14. Rammohan K. W., McFarland H. F., McFarlin D. E. Induction of subacute murine measles encephalitis by monoclonal antibody to virus haemagglutinin. Nature. 1981 Apr 16;290(5807):588–589. doi: 10.1038/290588a0. [DOI] [PubMed] [Google Scholar]
  15. Schmaljohn A. L., Johnson E. D., Dalrymple J. M., Cole G. A. Non-neutralizing monoclonal antibodies can prevent lethal alphavirus encephalitis. Nature. 1982 May 6;297(5861):70–72. doi: 10.1038/297070a0. [DOI] [PubMed] [Google Scholar]
  16. Wolinsky J. S., Stroop W. G. Virulence and persistence of three prototype strains of mumps virus in newborn hamsters. Arch Virol. 1978;57(4):355–359. doi: 10.1007/BF01320075. [DOI] [PubMed] [Google Scholar]
  17. Wolinsky J. S., Waxham M. N., Server A. C. Protective effects of glycoprotein-specific monoclonal antibodies on the course of experimental mumps virus meningoencephalitis. J Virol. 1985 Mar;53(3):727–734. doi: 10.1128/jvi.53.3.727-734.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

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