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. 1986 Dec;60(3):895–901. doi: 10.1128/jvi.60.3.895-901.1986

Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.

P J Cote, M Shapiro, R E Engle, H Popper, R H Purcell, J L Gerin
PMCID: PMC253316  PMID: 3783820

Abstract

Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver disease. Three woodchucks immunized with HBsAg developed antibodies to HBsAg which did not cross-react with WHsAg. After challenge with WHV, all three woodchucks developed typical acute infections with associated hepatic lesions. Serological studies with the cross-reactive antibodies raised in chimpanzees suggested that the protective epitopes of WHsAg were related to the group a specificity of HBsAg. These studies indicated that cross-protective epitopes are shared by HBV and WHV; however, the humoral response to these epitopes can vary among species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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