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. 1988 Sep;62(9):3506–3508. doi: 10.1128/jvi.62.9.3506-3508.1988

Spontaneous production of interleukin-2 and interleukin-3 by spleen cells from mice infected with mouse hepatitis virus type 4.

S Kyuwa 1, K Yamaguchi 1, M Hayami 1, J Hilgers 1, K Fujiwara 1
PMCID: PMC253478  PMID: 2841500

Abstract

Spleen cells from mice, 4 to 60 days after infection with mouse hepatitis virus type 4, produced interleukin-2, as well as interleukin-3, in the absence of exogenous stimulants in vitro. This unique lymphokine production by mouse hepatitis virus type 4 infection was controlled by host genes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acha-Orbea H., McDevitt H. O. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2435–2439. doi: 10.1073/pnas.84.8.2435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Casebolt D. B., Spalding D. M., Schoeb T. R., Lindsey J. R. Suppression of immune response induction in Peyer's patch lymphoid cells from mice infected with mouse hepatitis virus. Cell Immunol. 1987 Oct 1;109(1):97–103. doi: 10.1016/0008-8749(87)90295-4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ertl H. C., Finberg R. W. Characteristics and functions of Sendai virus-specific T-cell clones. J Virol. 1984 May;50(2):425–431. doi: 10.1128/jvi.50.2.425-431.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gillis S., Ferm M. M., Ou W., Smith K. A. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol. 1978 Jun;120(6):2027–2032. [PubMed] [Google Scholar]
  5. Hilgers J., Arends J. A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains. Curr Top Microbiol Immunol. 1985;122:31–37. doi: 10.1007/978-3-642-70740-7_4. [DOI] [PubMed] [Google Scholar]
  6. Hirano N., Fujiwara K., Hino S., Matumoto M. Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture. Arch Gesamte Virusforsch. 1974;44(3):298–302. doi: 10.1007/BF01240618. [DOI] [PubMed] [Google Scholar]
  7. Katagiri T., Tomiyama H., Kyuwa S., Kano K. Interleukin-2 responses of MRL/lpr mouse splenocytes and lymph node cells induced by TPA and A23187. Int Arch Allergy Appl Immunol. 1987;83(2):167–173. doi: 10.1159/000234350. [DOI] [PubMed] [Google Scholar]
  8. Knobler R. L., Haspel M. V., Oldstone M. B. Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease. J Exp Med. 1981 Apr 1;153(4):832–843. doi: 10.1084/jem.153.4.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kyuwa S., Yamaguchi K., Hayami M., Fujiwara K. Characterization of mouse hepatitis virus-reactive T cell clones. Adv Exp Med Biol. 1987;218:391–398. doi: 10.1007/978-1-4684-1280-2_48. [DOI] [PubMed] [Google Scholar]
  10. Lattime E. C., Gillis S., Pecoraro G., Stutman O. Ia-dependent interleukin 2 production in syngeneic cellular interactions. J Immunol. 1982 Jan;128(1):480–485. [PubMed] [Google Scholar]
  11. Massa P. T., Dörries R., ter Meulen V. Viral particles induce Ia antigen expression on astrocytes. Nature. 1986 Apr 10;320(6062):543–546. doi: 10.1038/320543a0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Saneto R. P., Altman A., Knobler R. L., Johnson H. M., de Vellis J. Interleukin 2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9221–9225. doi: 10.1073/pnas.83.23.9221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Smith A. L., Bottomly K., Winograd D. F. Altered splenic T cell function of BALB/cByJ mice infected with mouse hepatitis virus or Sendai virus. J Immunol. 1987 May 15;138(10):3426–3430. [PubMed] [Google Scholar]
  14. Taguchi O., Nishizuka Y. Self tolerance and localized autoimmunity. Mouse models of autoimmune disease that suggest tissue-specific suppressor T cells are involved in self tolerance. J Exp Med. 1987 Jan 1;165(1):146–156. doi: 10.1084/jem.165.1.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tamura T., Fujiwara K. IgM and IgG response to sheep red blood cells in mouse hepatitis virus-infected nude mice. Microbiol Immunol. 1979;23(3):177–183. doi: 10.1111/j.1348-0421.1979.tb00454.x. [DOI] [PubMed] [Google Scholar]
  16. Tamura T., Machii K., Ueda K., Fujiwara K. Modification of immune response in nude mice infected with mouse hepatitis virus. Microbiol Immunol. 1978;22(9):557–564. doi: 10.1111/j.1348-0421.1978.tb00403.x. [DOI] [PubMed] [Google Scholar]
  17. Truneh A., Albert F., Golstein P., Schmitt-Verhulst A. M. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature. 1985 Jan 24;313(6000):318–320. doi: 10.1038/313318a0. [DOI] [PubMed] [Google Scholar]

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