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. 1988 Oct;62(10):3896–3899. doi: 10.1128/jvi.62.10.3896-3899.1988

Duplication of noncoding sequences in polyomavirus specifically augments the development of thymic tumors in mice.

R Freund 1, C J Dawe 1, T L Benjamin 1
PMCID: PMC253541  PMID: 2843686

Abstract

A 40-base-pair duplication of noncoding sequences in polyomavirus specifically augmented the development of thymic epitheliomas following inoculation of virus into newborn mice. Virus strains carrying only one copy of this sequence induced a full spectrum of tumors except for overt thymic tumors. This 40-base-pair repeat, on the early side of the replication origin, constituted a tissue-specific regulatory determinant for tumor induction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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