Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1982;60(3):389–394.

Immunogenicity and reactogenicity of a Q fever chemovaccine in persons professionally exposed to Q fever in Czechoslovakia

J Kazár, R Brezina, A Palanová, B Tvrdá, Š Schramek
PMCID: PMC2536007  PMID: 6982774

Abstract

An immunization trial carried out on 1310 persons professionally exposed to Q fever confirmed the suitability of a chemovaccine for field use. Its immunogenicity and reactogenicity differed in three groups of subjects who differed in their previous experience of Q fever and who were given different lots of the vaccine. There was some correlation between reactogenicity of the vaccine and pre-immunization positivity in the microagglutination and skin tests as indicators of a previous exposure. The skin test was more reliable for predicting post-immunization reactions.

Full text

PDF
393

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERMAN S., COLE G., LOWENTHAL J. P., GOCHENOUR R. B. Safety test for Q fever vaccine. J Bacteriol. 1960 May;79:747–751. doi: 10.1128/jb.79.5.747-751.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brezina R., Murray E. S., Tarizzo M. L., Bögel K. Rickettsiae and rickettsial diseases. Bull World Health Organ. 1973;49(5):433–442. [PMC free article] [PubMed] [Google Scholar]
  3. Crăcea E., Dumitrescu-Constantinescu S., Botez D., Ioanid L. Q-fever soluble vaccine effects in Coxiella burneti sensitized humans. Zentralbl Bakteriol Orig A. 1977 Jul;238(3):413–418. [PubMed] [Google Scholar]
  4. Crăcea E., Dumitrescu S., Botez D., Toma E., Bandu C., Sabin S., Ioanid L., Chirescu N. Immunization in man with a soluble Q fever vaccine. Arch Roum Pathol Exp Microbiol. 1973 Mar;32(1):45–51. [PubMed] [Google Scholar]
  5. D'Angelo L. J., Baker E. F., Schlosser W. From the Center for Disease Control: Q fever in the United States, 1948--1977. J Infect Dis. 1979 May;139(5):613–615. doi: 10.1093/infdis/139.5.613. [DOI] [PubMed] [Google Scholar]
  6. Genig V. A., Kniazeva E. N., Tsel'nikov P. S., Miroshnichenko M. M. Opyt massovoi immunizatsii liudei zhivoi vaktsinoi M-44 protiv Ku likhoradki. I. Podkozhnyi metod immunizatsii. Vopr Virusol. 1965 May-Jun;10(3):319–323. [PubMed] [Google Scholar]
  7. Johnson J. W., Eddy G. A., Pedersen C. E., Jr Biological properties of the M-44 strain of Coxiella burneti. J Infect Dis. 1976 Mar;133(3):334–338. doi: 10.1093/infdis/133.3.334. [DOI] [PubMed] [Google Scholar]
  8. Johnson J. W., McLeod C. G., Stookey J. L., Higbee G. A., Pedersen C. E., Jr Lesions in guinea pigs infected with Coxiella burnetii strain M-44. J Infect Dis. 1977 Jun;135(6):995–998. doi: 10.1093/infdis/135.6.995. [DOI] [PubMed] [Google Scholar]
  9. Kazár J., Brezina R., Schramek S., Palanová A., Tvrdá B. Suitability of the microagglutination test for detection of post-infection and post-vaccination Q fever antibodies in human sera. Acta Virol. 1981 Jul;25(4):235–240. [PubMed] [Google Scholar]
  10. Marmion B. P. Development of Q-fever vaccines, 1937 to 1967. Med J Aust. 1967 Dec 9;2(24):1074–1078. doi: 10.5694/j.1326-5377.1967.tb27293.x. [DOI] [PubMed] [Google Scholar]
  11. ORMSBEE R. A., BELL E. J., LACKMAN D. B., TALLENT G. THE INFLUENCE OF PHASE ON THE PROTECTIVE POTENCY OF Q FEVER VACCINE. J Immunol. 1964 Mar;92:404–412. [PubMed] [Google Scholar]
  12. Schramek S., Brezina R., Pospísil V. Improved method of preparing phase II Coxiella burneti antigen for the microagglutination test. Acta Virol. 1970 Sep;14(5):415–415. [PubMed] [Google Scholar]
  13. Sen G. P., De S., Chakravorty A. K., Saha S. C., Bera A., Khanna P. N. Sero-epidemiological evidence of Coxiella burnetii infection among selected human population in Calcutta. Indian J Med Res. 1978 Dec;68:911–916. [PubMed] [Google Scholar]
  14. VIVONA S., LOWENTHAL J. P., BERMAN S., BENENSON A. S., SMADEL J. E. REPORT OF A FIELD STUDY WITH Q FEVER VACCINE. Am J Hyg. 1964 Mar;79:143–153. doi: 10.1093/oxfordjournals.aje.a120370. [DOI] [PubMed] [Google Scholar]
  15. Vanek E., Thimm B. Q fever in Kenya. Serological investigations in man and domestic animals. East Afr Med J. 1976 Dec;53(12):678–684. [PubMed] [Google Scholar]
  16. de Ruiz H. L. Q fever in Colombia, S.A. A serological survey of human and bovine populations. Zentralbl Veterinarmed B. 1977;24(4):287–292. doi: 10.1111/j.1439-0450.1977.tb01000.x. [DOI] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES