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. 1988 Dec;62(12):4824–4827. doi: 10.1128/jvi.62.12.4824-4827.1988

A repeat sequence, GGGTTA, is shared by DNA of human herpesvirus 6 and Marek's disease virus.

M Kishi 1, H Harada 1, M Takahashi 1, A Tanaka 1, M Hayashi 1, M Nonoyama 1, S F Josephs 1, A Buchbinder 1, F Schachter 1, D V Ablashi 1, et al.
PMCID: PMC253608  PMID: 2846894

Abstract

Some regions of the genomes of human B-lymphotrophic virus (HBLV), also designated as human herpesvirus 6, and Marek's disease virus were found to hybridize to each other under moderate to stringent conditions, scoring from 10 to 30% base-pair mismatch. Nucleotide sequence analysis showed that a 6-base-pair repetitive sequence, GGGTTA (DR2), present in the IRS-IRL junction region of the Marek's disease virus genome, was also reiterated in the HBLV genome. The function(s) of such a sequence is unknown, but this is the first report of homology between HBLV and a nonhuman herpesvirus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablashi D. V., Salahuddin S. Z., Josephs S. F., Imam F., Lusso P., Gallo R. C., Hung C., Lemp J., Markham P. D. HBLV (or HHV-6) in human cell lines. Nature. 1987 Sep 17;329(6136):207–207. doi: 10.1038/329207a0. [DOI] [PubMed] [Google Scholar]
  2. Balachandran N., Oba D. E., Hutt-Fletcher L. M. Antigenic cross-reactions among herpes simplex virus types 1 and 2, Epstein-Barr virus, and cytomegalovirus. J Virol. 1987 Apr;61(4):1125–1135. doi: 10.1128/jvi.61.4.1125-1135.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Biberfeld P., Kramarsky B., Salahuddin S. Z., Gallo R. C. Ultrastructural characterization of a new human B lymphotropic DNA virus (human herpesvirus 6) isolated from patients with lymphoproliferative disease. J Natl Cancer Inst. 1987 Nov;79(5):933–941. [PubMed] [Google Scholar]
  4. Calnek B. W. Marek's disease--a model for herpesvirus oncology. Crit Rev Microbiol. 1986;12(4):293–320. doi: 10.3109/10408418509104432. [DOI] [PubMed] [Google Scholar]
  5. Downing R. G., Sewankambo N., Serwadda D., Honess R., Crawford D., Jarrett R., Griffin B. E. Isolation of human lymphotropic herpesviruses from Uganda. Lancet. 1987 Aug 15;2(8555):390–390. doi: 10.1016/s0140-6736(87)92403-2. [DOI] [PubMed] [Google Scholar]
  6. Efstathiou S., Gompels U. A., Craxton M. A., Honess R. W., Ward K. DNA homology between a novel human herpesvirus (HHV-6) and human cytomegalovirus. Lancet. 1988 Jan 2;1(8575-6):63–64. doi: 10.1016/s0140-6736(88)91049-5. [DOI] [PubMed] [Google Scholar]
  7. Evans D. L., Barnett J. W., Bowen J. M., Dmochowski L. Antigenic relationship between the herpesviruses of infectious bovine rhinotracheitis, Marek's disease, and Burkitt's lymphoma. J Virol. 1972 Aug;10(2):277–287. doi: 10.1128/jvi.10.2.277-287.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fabricant C. G. Atherosclerosis: the consequence of infection with a herpesvirus. Adv Vet Sci Comp Med. 1985;30:39–66. [PubMed] [Google Scholar]
  9. Fukuchi K., Sudo M., Lee Y. S., Tanaka A., Nonoyama M. Structure of Marek's disease virus DNA: detailed restriction enzyme map. J Virol. 1984 Jul;51(1):102–109. doi: 10.1128/jvi.51.1.102-109.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fukuchi K., Sudo M., Tanaka A., Nonoyama M. Map location of homologous regions between Marek's disease virus and herpesvirus of turkey and the absence of detectable homology in the putative tumor-inducing gene. J Virol. 1985 Mar;53(3):994–997. doi: 10.1128/jvi.53.3.994-997.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Igarashi T., Takahashi M., Donovan J., Jessip J., Smith M., Hirai K., Tanaka A., Nonoyama M. Restriction enzyme map of herpesvirus of turkey DNA and its collinear relationship with Marek's disease virus DNA. Virology. 1987 Apr;157(2):351–358. doi: 10.1016/0042-6822(87)90277-7. [DOI] [PubMed] [Google Scholar]
  12. Josephs S. F., Buchbinder A., Streicher H. Z., Ablashi D. V., Salahuddin S. Z., Guo H. G., Wong-Staal F., Cossman J., Raffeld M., Sundeen J. Detection of human B-lymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients. Leukemia. 1988 Mar;2(3):132–135. [PubMed] [Google Scholar]
  13. Josephs S. F., Salahuddin S. Z., Ablashi D. V., Schachter F., Wong-Staal F., Gallo R. C. Genomic analysis of the human B-lymphotropic virus (HBLV). Science. 1986 Oct 31;234(4776):601–603. doi: 10.1126/science.3020691. [DOI] [PubMed] [Google Scholar]
  14. Lee Y. S., Tanaka A., Silver S., Smith M., Nonoyama M. Minor DNA homology between herpesvirus of turkey and Marek's disease virus? Virology. 1979 Feb;93(1):277–280. doi: 10.1016/0042-6822(79)90299-x. [DOI] [PubMed] [Google Scholar]
  15. Leib D. A., Bradbury J. M., Hart C. A., McCarthy K. Genome isomerism in two alphaherpesviruses: Herpesvirus saimiri-1 (Herpesvirus tamarinus) and avian infectious laryngotracheitis virus. Brief report. Arch Virol. 1987;93(3-4):287–294. doi: 10.1007/BF01310982. [DOI] [PubMed] [Google Scholar]
  16. Lusso P., Salahuddin S. Z., Ablashi D. V., Gallo R. C., Di Marzo Veronese F., Markham P. D. Diverse tropism of HBLV (human herpesvirus 6) Lancet. 1987 Sep 26;2(8561):743–743. doi: 10.1016/s0140-6736(87)91103-2. [DOI] [PubMed] [Google Scholar]
  17. Makari J. G. Association between Marek's herpesvirus and human cancer. I. Detection of cross-reacting antigens between chicken tumors and human tumors. Oncology. 1973;28(2):164–176. doi: 10.1159/000224813. [DOI] [PubMed] [Google Scholar]
  18. Makari J. G. Association between Marek's herpesvirus and human cancer. II. Detection of structural viral antigens in chicken tumors and human tumors. Oncology. 1973;28(2):177–883. doi: 10.1159/000224814. [DOI] [PubMed] [Google Scholar]
  19. Mocarski E. S., Post L. E., Roizman B. Molecular engineering of the herpes simplex virus genome: insertion of a second L-S junction into the genome causes additional genome inversions. Cell. 1980 Nov;22(1 Pt 1):243–255. doi: 10.1016/0092-8674(80)90172-5. [DOI] [PubMed] [Google Scholar]
  20. Mocarski E. S., Roizman B. Site-specific inversion sequence of the herpes simplex virus genome: domain and structural features. Proc Natl Acad Sci U S A. 1981 Nov;78(11):7047–7051. doi: 10.1073/pnas.78.11.7047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Naito M., Ono K., Doi T., Kato S., Tanabe S. Antibodies in human and monkey sera to herpes-type virus from a chicken with Marek's disease and to EB virus detected by the immunofluorescence test. Biken J. 1971 Jun;14(2):161–166. [PubMed] [Google Scholar]
  22. Naito M., Ono K., Tanabe S., Doi T., Kato S. Detection in chicken and human sera of antibody against herpes type virus from a chicken with Marek's disease and EB virus demonstrated by the indirect immunofluorescence test. Biken J. 1970 Sep;13(3):205–212. [PubMed] [Google Scholar]
  23. Okazaki W., Purchase H. G., Burmester B. R. Protection against Marek's disease by vaccination with a herpesvirus of turkeys. Avian Dis. 1970 May;14(2):413–429. [PubMed] [Google Scholar]
  24. Ono K., Tanabe S., Naito M., Doi T., Kato S. Antigen common to a herpes type virus from chickens with Marek's disease and EB virus from Burkitt's lymphoma cells. Biken J. 1970 Sep;13(3):213–217. [PubMed] [Google Scholar]
  25. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  26. Sharma J. M., Witter R. L., Burmester B. R., Landon J. C. Public health implications of Marek's disease virus and herpesvirus of turkeyes. Studies on human and subhuman primates. J Natl Cancer Inst. 1973 Oct;51(4):1123–1128. doi: 10.1093/jnci/51.4.1123. [DOI] [PubMed] [Google Scholar]
  27. Sheldrick P., Berthelot N. Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harb Symp Quant Biol. 1975;39(Pt 2):667–678. doi: 10.1101/sqb.1974.039.01.080. [DOI] [PubMed] [Google Scholar]
  28. Tedder R. S., Briggs M., Cameron C. H., Honess R., Robertson D., Whittle H. A novel lymphotropic herpesvirus. Lancet. 1987 Aug 15;2(8555):390–392. doi: 10.1016/s0140-6736(87)92404-4. [DOI] [PubMed] [Google Scholar]
  29. Van Zaane D., Brinkhof J. M., Gielkens A. L. Molecular-biological characterization of Marek's disease virus. II. Differentiation of various MDV and HVT strains. Virology. 1982 Aug;121(1):133–146. doi: 10.1016/0042-6822(82)90123-4. [DOI] [PubMed] [Google Scholar]
  30. Van Zaane D., Brinkhof J. M., Westenbrink F., Gielkens A. L. Molecular-biological characterization of Marek's disease virus. I. Identification of virus-specific polypeptides in infected cells. Virology. 1982 Aug;121(1):116–132. doi: 10.1016/0042-6822(82)90122-2. [DOI] [PubMed] [Google Scholar]
  31. Vlazny D. A., Kwong A., Frenkel N. Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA. Proc Natl Acad Sci U S A. 1982 Mar;79(5):1423–1427. doi: 10.1073/pnas.79.5.1423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Wadsworth S., Jacob R. J., Roizman B. Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions. J Virol. 1975 Jun;15(6):1487–1497. doi: 10.1128/jvi.15.6.1487-1497.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. doi: 10.1016/s0140-6736(88)91893-4. [DOI] [PubMed] [Google Scholar]

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