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. 1984;62(5):737–741.

Antibody response to measles immunization in India*

J S Job, T J John, A Joseph
PMCID: PMC2536227  PMID: 6334571

Abstract

Antibody response to measles vaccine was measured in 238 subjects aged 6-15 months. Seroconversion rates ranged from 74% at 6 months of age to 100% at 13-15 months; the differences in age-specific rates were not statistically significant. The postimmunization antibody titres increased with increasing age of the vaccinee. Seroconversion rates and antibody titres in 49 subjects with grades I and II malnutrition were not significantly different from those in the 189 normal subjects.

These results support the recommendation of 9 months as a satisfactory age for commencement of measles immunization in India. However, the highest antibody levels and seroconversion rates were obtained in children over 12 months of age.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bhatnagar S. K., Mohan M., Kumar P., Balaya S., Prabhakar A. K., Bhargava S. K. Optimum age for measles immunisation: study of pre- and post-immunization level of HI antibody titres. Indian Pediatr. 1981 Sep;18(9):625–629. [PubMed] [Google Scholar]
  2. Centers for Disease Control (CDC) Recommendation of the Immunization Practices Advisory Committee (ACIP). Measles prevention. MMWR Morb Mortal Wkly Rep. 1982 May 7;31(17):217-24, 229-31. [PubMed] [Google Scholar]
  3. Cherry J. D., Feigin R. D., Lobes L. A., Jr, Hinthorn D. R., Shackelford P. G., Shirley R. H., Lins R. D., Choi S. C. Urban measles in the vaccine era: a clinical, epidemiologic, and serologic study. J Pediatr. 1972 Aug;81(2):217–230. doi: 10.1016/s0022-3476(72)80287-7. [DOI] [PubMed] [Google Scholar]
  4. Ghosh S., Kumari S., Bhargava S. K. Antibody titres after measles vaccine. Indian J Med Res. 1977 Aug;66(2):165–171. [PubMed] [Google Scholar]
  5. Hull H. F., Williams P. J., Oldfield F. Measles mortality and vaccine efficacy in rural West Africa. Lancet. 1983 Apr 30;1(8331):972–975. doi: 10.1016/s0140-6736(83)92091-3. [DOI] [PubMed] [Google Scholar]
  6. Ifekwunigwe A. E., Grasset N., Glass R., Foster S. Immune responses to measles and smallpox vaccinations in malnourished children. Am J Clin Nutr. 1980 Mar;33(3):621–624. doi: 10.1093/ajcn/33.3.621. [DOI] [PubMed] [Google Scholar]
  7. John T. J., Jesudoss E. S. A survey of measles antibody in children. Indian Pediatr. 1973 Feb;10(2):65–66. [PubMed] [Google Scholar]
  8. John T. J., Joseph A., George T. I., Radhakrishnan J., Singh R. P., George K. Epidemiology and prevention of measles in rural south India. Indian J Med Res. 1980 Aug;72:153–158. [PubMed] [Google Scholar]
  9. Krishnamurthy K. A., Anantharaman V. Measles a dangerous disease: a study of 1000 cases in Madurai. Indian Pediatr. 1974 Apr;11(4):267–271. [PubMed] [Google Scholar]
  10. Krugman R. D., Rosenberg R., McIntosh K., Herrmann K., Witte J. J., Ennis F. A., Meyer B. C. Further attenuated live measles vaccines: the need for revised recommendations. J Pediatr. 1977 Nov;91(5):766–767. doi: 10.1016/s0022-3476(77)81036-6. [DOI] [PubMed] [Google Scholar]
  11. Krugman S. Present status of measles and rubella immunization in the United States: a medical progress report. J Pediatr. 1971 Jan;78(1):1–16. doi: 10.1016/s0022-3476(71)80259-7. [DOI] [PubMed] [Google Scholar]
  12. Marks J. S., Halpin T. J., Orenstein W. A. Measles vaccine efficacy in children previously vaccinated at 12 months of age. Pediatrics. 1978 Dec;62(6):955–960. [PubMed] [Google Scholar]
  13. Mittal S. K., Gulati A., Kumari P., Bala V., Gupta S. Seroconversion following measles immunisation. Indian Pediatr. 1979 Apr;16(4):309–311. [PubMed] [Google Scholar]
  14. Reynolds D. W., Start A. Immunity to measles in children vaccinated before and after 1 year of age. Am J Dis Child. 1972 Dec;124(6):848–850. doi: 10.1001/archpedi.1972.02110180050006. [DOI] [PubMed] [Google Scholar]
  15. Shah U., Banerji K. L., Nanavati A. N., Mehta N. A. A test survey of measles in a rural community in India. Bull World Health Organ. 1972;46(1):130–138. [PMC free article] [PubMed] [Google Scholar]
  16. Shasby D. M., Shope T. C., Downs H., Herrmann K. L., Polkowski J. Epidemic measles in a highly vaccinated population. N Engl J Med. 1977 Mar 17;296(11):585–589. doi: 10.1056/NEJM197703172961102. [DOI] [PubMed] [Google Scholar]
  17. Wallace R. B., Landrigan P. J., Smith E. A., Pifer J., Teller B., Foster S. O. Trial of a reduced dose of measles vaccine in Nigerian children. Bull World Health Organ. 1976;53(4):361–364. [PMC free article] [PubMed] [Google Scholar]
  18. Wilkins J., Wehrle P. F., Portnoy B. Live, further attenuated rubella vaccine. Serologic responses among term and low birth weight infants. Am J Dis Child. 1972 Mar;123(3):190–192. doi: 10.1001/archpedi.1972.02110090060002. [DOI] [PubMed] [Google Scholar]

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