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. 1988 Mar;62(3):1066–1070. doi: 10.1128/jvi.62.3.1066-1070.1988

Human immune responses to major human cytomegalovirus glycoprotein complexes.

Y N Liu 1, B Kari 1, R C Gehrz 1
PMCID: PMC253669  PMID: 2828655

Abstract

Sera from both human cytomegalovirus (HCMV)-seropositive adults and infants with congenital HCMV infection recognized two major HCMV glycoprotein complexes. However, proliferative responses of peripheral blood mononuclear cells to these complexes varied among seropositive adults and were not detected in any of the infants. Thus, these glycoproteins alone may not be sufficient to develop a subviral HCMV vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arvin A. M., Kinney-Thomas E., Shriver K., Grose C., Koropchak C. M., Scranton E., Wittek A. E., Diaz P. S. Immunity to varicella-zoster viral glycoproteins, gp I (gp 90/58) and gp III (gp 118), and to a nonglycosylated protein, p 170. J Immunol. 1986 Aug 15;137(4):1346–1351. [PubMed] [Google Scholar]
  2. Balfour H. H., Jr, Slade M. S., Kalis J. M., Howard R. J., Simmons R. L., Najarian J. S. Viral infections in renal transplant donors and their recipients: a prospective study. Surgery. 1977 May;81(5):487–492. [PubMed] [Google Scholar]
  3. Bennink J. R., Yewdell J. W., Smith G. L., Moller C., Moss B. Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells. Nature. 1984 Oct 11;311(5986):578–579. doi: 10.1038/311578a0. [DOI] [PubMed] [Google Scholar]
  4. Britt W. J. Neutralizing antibodies detect a disulfide-linked glycoprotein complex within the envelope of human cytomegalovirus. Virology. 1984 Jun;135(2):369–378. doi: 10.1016/0042-6822(84)90193-4. [DOI] [PubMed] [Google Scholar]
  5. Cranage M. P., Kouzarides T., Bankier A. T., Satchwell S., Weston K., Tomlinson P., Barrell B., Hart H., Bell S. E., Minson A. C. Identification of the human cytomegalovirus glycoprotein B gene and induction of neutralizing antibodies via its expression in recombinant vaccinia virus. EMBO J. 1986 Nov;5(11):3057–3063. doi: 10.1002/j.1460-2075.1986.tb04606.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Farrar G. H., Oram J. D. Characterization of the human cytomegalovirus envelope glycoproteins. J Gen Virol. 1984 Nov;65(Pt 11):1991–2001. doi: 10.1099/0022-1317-65-11-1991. [DOI] [PubMed] [Google Scholar]
  7. Forman S. J., Zaia J. A., Clark B. R., Wright C. L., Mills B. J., Pottathil R., Racklin B. C., Gallagher M. T., Welte K., Blume K. G. A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. J Immunol. 1985 May;134(5):3391–3395. [PubMed] [Google Scholar]
  8. Fulginiti V. A., Scribner R., Groth C. G., Putnam C. W., Brettschneider L., Gilbert S., Porter K. A., Starzl T. E. Infections in recipients of liver homografts. N Engl J Med. 1968 Sep 19;279(12):619–626. doi: 10.1056/NEJM196809192791202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gehrz R. C., Marker S. C., Balfour H. H., Jr Specific cell-mediated immune defect in congenital cytomegalovirus infection. Lancet. 1977 Apr 9;1(8015):811–812. doi: 10.1016/s0140-6736(77)93007-0. [DOI] [PubMed] [Google Scholar]
  10. Gehrz R. C., Marker S. C., Knorr S. O., Kalis J. M., Balfour H. H., Jr Specific cell-mediated immune defect in active cytomegalovirus infection of young children and their mothers. Lancet. 1977 Oct 22;2(8043):844–847. doi: 10.1016/s0140-6736(77)90782-6. [DOI] [PubMed] [Google Scholar]
  11. Gönczöl E., Hudecz F., Ianacone J., Dietzschold B., Starr S., Plotkin S. A. Immune responses to isolated human cytomegalovirus envelope proteins. J Virol. 1986 May;58(2):661–664. doi: 10.1128/jvi.58.2.661-664.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kari B., Lussenhop N., Goertz R., Wabuke-Bunoti M., Radeke R., Gehrz R. Characterization of monoclonal antibodies reactive to several biochemically distinct human cytomegalovirus glycoprotein complexes. J Virol. 1986 Nov;60(2):345–352. doi: 10.1128/jvi.60.2.345-352.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Koprowski H., Gerhard W., Croce C. M. Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2985–2988. doi: 10.1073/pnas.74.7.2985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Masur H., Michelis M. A., Greene J. B., Onorato I., Stouwe R. A., Holzman R. S., Wormser G., Brettman L., Lange M., Murray H. W. An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction. N Engl J Med. 1981 Dec 10;305(24):1431–1438. doi: 10.1056/NEJM198112103052402. [DOI] [PubMed] [Google Scholar]
  15. Myers J. D., Spencer H. C., Jr, Watts J. C., Gregg M. B., Stewart J. A., Troupin R. H., Thomas E. D. Cytomegalovirus pneumonia after human marrow transplantation. Ann Intern Med. 1975 Feb;82(2):181–188. doi: 10.7326/0003-4819-82-2-181. [DOI] [PubMed] [Google Scholar]
  16. Pereira L., Hoffman M., Gallo D., Cremer N. Monoclonal antibodies to human cytomegalovirus: three surface membrane proteins with unique immunological and electrophoretic properties specify cross-reactive determinants. Infect Immun. 1982 Jun;36(3):924–932. doi: 10.1128/iai.36.3.924-932.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Peterson P. K., Balfour H. H., Jr, Marker S. C., Fryd D. S., Howard R. J., Simmons R. L. Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation. Medicine (Baltimore) 1980 Jul;59(4):283–300. [PubMed] [Google Scholar]
  18. Rasmussen L. E., Nelson R. M., Kelsall D. C., Merigan T. C. Murine monoclonal antibody to a single protein neutralizes the infectivity of human cytomegalovirus. Proc Natl Acad Sci U S A. 1984 Feb;81(3):876–880. doi: 10.1073/pnas.81.3.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Rasmussen L., Mullenax J., Nelson R., Merigan T. C. Viral polypeptides detected by a complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus. J Virol. 1985 Aug;55(2):274–280. doi: 10.1128/jvi.55.2.274-280.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Reynolds D. W., Dean P. H., Pass R. F., Alford C. A. Specific cell-mediated immunity in children with congenital and neonatal cytomegalovirus infection and their mothers. J Infect Dis. 1979 Oct;140(4):493–499. doi: 10.1093/infdis/140.4.493. [DOI] [PubMed] [Google Scholar]
  21. Siegal F. P., Lopez C., Hammer G. S., Brown A. E., Kornfeld S. J., Gold J., Hassett J., Hirschman S. Z., Cunningham-Rundles C., Adelsberg B. R. Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med. 1981 Dec 10;305(24):1439–1444. doi: 10.1056/NEJM198112103052403. [DOI] [PubMed] [Google Scholar]
  22. Starr S. E., Tolpin M. D., Friedman H. M., Paucker K., Plotkin S. A. Impaired cellular immunity to cytomegalovirus in congenitally infected children and their mothers. J Infect Dis. 1979 Oct;140(4):500–505. doi: 10.1093/infdis/140.4.500. [DOI] [PubMed] [Google Scholar]
  23. Stinson E. B., Bieber C. P., Griepp R. B., Clark D. A., Shumway N. E., Remington J. S. Infectious complications after cardiac transplantation in man. Ann Intern Med. 1971 Jan;74(1):22–36. doi: 10.7326/0003-4819-74-1-22. [DOI] [PubMed] [Google Scholar]
  24. Townsend A. R., McMichael A. J., Carter N. P., Huddleston J. A., Brownlee G. G. Cytotoxic T cell recognition of the influenza nucleoprotein and hemagglutinin expressed in transfected mouse L cells. Cell. 1984 Nov;39(1):13–25. doi: 10.1016/0092-8674(84)90187-9. [DOI] [PubMed] [Google Scholar]
  25. Weller T. H. The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. I. N Engl J Med. 1971 Jul 22;285(4):203–214. doi: 10.1056/NEJM197107222850406. [DOI] [PubMed] [Google Scholar]
  26. Yewdell J. W., Bennink J. R., Smith G. L., Moss B. Influenza A virus nucleoprotein is a major target antigen for cross-reactive anti-influenza A virus cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1985 Mar;82(6):1785–1789. doi: 10.1073/pnas.82.6.1785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. ten Napel C. H., The T. H. Acute cytomegalovirus infection and the host immune response. I. Development and maintenance of cytomegalovirus (CMV) induced in vitro lymphocyte reactivity and its relationship to the production of CMV antibodies. Clin Exp Immunol. 1980 Feb;39(2):263–271. [PMC free article] [PubMed] [Google Scholar]
  28. ten Napel C. H., The T. H. Acute cytomegalovirus infection and the host immune response. II. Relationship of suppressed in vitro lymphocyte reactivity to bacterial recall antigens and mitogens with the development of cytomegalovirus-induced lymphocyte reactivity. Clin Exp Immunol. 1980 Feb;39(2):272–278. [PMC free article] [PubMed] [Google Scholar]

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