Abstract
A 10-year-old girl initially presented with clinical features and thyroid function tests consistent with hyperthyroidism. She was treated with propylthiouracil, 100 mg, three times a day. She developed jaundice and hepatitis following treatment with propylthiouracil for 40 days. Clinical features of hepatitis improved after the discontinuation of propylthiouracil and she became euthyroid. At this time, an immunofluorescent technique revealed antibodies consistent with autoimmune thyroiditis. From this report, it appears that hepatitis is one of the infrequent complications of treatment with propylthiouracil and transient hyperthyroidism may be associated with autoimmune thyroiditis.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- COLWELL A. R., Jr, SANDO D. E., LANG S. J. Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death. J Am Med Assoc. 1952 Feb 23;148(8):639–641. doi: 10.1001/jama.1952.62930080001013. [DOI] [PubMed] [Google Scholar]
- Fatourechi V., McConahey W. M., Woolner L. B. Hyperthyroidism associated with histologic Hashimoto's thyroiditis. Mayo Clin Proc. 1971 Oct;46(10):682–689. [PubMed] [Google Scholar]
- Monteleone J. A., Danis R. K., Tung K. S., Ramos C. V., Peden V. H. Differentiation of chronic lymphocytic thyroiditis and simple goiter in pediatrics. J Pediatr. 1973 Sep;83(3):381–385. doi: 10.1016/s0022-3476(73)80259-8. [DOI] [PubMed] [Google Scholar]
- Parker L. N. Letter: Hepatitis and propylthiouracil. Ann Intern Med. 1975 Feb;82(2):228–229. doi: 10.7326/0003-4819-82-2-228_2. [DOI] [PubMed] [Google Scholar]
- Sato T., Takata I., Taketani T., Saida K., Nakajima H. Concurrence of Grave's disease and Hashimoto's thyroiditis. Arch Dis Child. 1977 Dec;52(12):951–955. doi: 10.1136/adc.52.12.951. [DOI] [PMC free article] [PubMed] [Google Scholar]