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. 1988 Aug;62(8):3073–3076. doi: 10.1128/jvi.62.8.3073-3076.1988

Immune responses are required to terminate viremia in equine infectious anemia lentivirus infection.

L E Perryman 1, K I O'Rourke 1, T C McGuire 1
PMCID: PMC253753  PMID: 2839723

Abstract

Six normal and four immunodeficient horses were injected with a cloned variant of equine infectious anemia virus (EIAV). The six normal horses had detectable EIAV in their plasma by 7 days postinjection. During their primary viremic episode, which was accompanied by fever and anemia, maximum titers of EIAV in plasma ranged from 10(3.8) to 10(4.8) 50% tissue culture infective doses per ml. All six normal horses cleared detectable virus from their plasma by 21 to 35 days after injection. Horses with combined immunodeficiency became viremic by 9 days postinjection and also developed anemia. In contrast to normal horses, foals with combined immunodeficiency did not eliminate the virus from their plasma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Banks K. L., Henson J. B., McGuire T. C. Immunologically mediated glomerulitis of horses. I. Pathogenesis in persistent infection by equine infectious anemia virus. Lab Invest. 1972 Jun;26(6):701–707. [PubMed] [Google Scholar]
  2. Banks K. L., McGuire T. C. Surface receptors on neutrophils and monocytes from immunodeficient and normal horses. Immunology. 1975 Mar;28(3):581–588. [PMC free article] [PubMed] [Google Scholar]
  3. Charman H. P., Bladen S., Gilden R. V., Coggins L. Equine infectious anemia virus: evidence favoring classification as a retravirus. J Virol. 1976 Sep;19(3):1073–1079. doi: 10.1128/jvi.19.3.1073-1079.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chiu I. M., Yaniv A., Dahlberg J. E., Gazit A., Skuntz S. F., Tronick S. R., Aaronson S. A. Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. 1985 Sep 26-Oct 2Nature. 317(6035):366–368. doi: 10.1038/317366a0. [DOI] [PubMed] [Google Scholar]
  5. Coggins L., Norcross N. L. Immunodiffusion reaction in equine infectious anemia. Cornell Vet. 1970 Apr;60(2):330–335. [PubMed] [Google Scholar]
  6. Haase A. T. Pathogenesis of lentivirus infections. Nature. 1986 Jul 10;322(6075):130–136. doi: 10.1038/322130a0. [DOI] [PubMed] [Google Scholar]
  7. Henson J. B., McGuire T. C. Immunopathology of equine infectious anemia. Am J Clin Pathol. 1971 Sep;56(3):306–313. doi: 10.1093/ajcp/56.3.306. [DOI] [PubMed] [Google Scholar]
  8. Leid R. W., Coley S. C., Blanchard D. P., Perryman L. E. Equine alternative pathway activation by unsensitized rabbit red blood cells. Vet Immunol Immunopathol. 1985 May;9(1):71–85. doi: 10.1016/0165-2427(85)90131-x. [DOI] [PubMed] [Google Scholar]
  9. Magnuson N. S., Perryman L. E., Wyatt C. R., Mason P. H., Talmadge J. E. Large granular lymphocytes from SCID horses develop potent cytotoxic activity after treatment with human recombinant interleukin 2. J Immunol. 1987 Jul 1;139(1):61–67. [PubMed] [Google Scholar]
  10. McGuire T. C., Banks K. L., Poppie M. J. Combined immunodeficiency in horses: characterization of the lymphocyte defect. Clin Immunol Immunopathol. 1975 Mar;3(4):555–566. doi: 10.1016/0090-1229(75)90080-x. [DOI] [PubMed] [Google Scholar]
  11. McGuire T. C., Crawford T. B. Immunology of a persistent retrovirus infection--equine infectious anemia. Adv Vet Sci Comp Med. 1979;23:137–159. [PubMed] [Google Scholar]
  12. McGuire T. C., Henson J. B., Burger D. Complement (C'3)-coated red blood cells following infection with the virus of equine infectious anemia. J Immunol. 1969 Aug;103(2):293–299. [PubMed] [Google Scholar]
  13. McGuire T. C., Henson J. B., Quist S. E. Impaired bone marrow response in equine infectious anemia. Am J Vet Res. 1969 Dec;30(12):2099–2104. [PubMed] [Google Scholar]
  14. McGuire T. C., Henson J. B., Quist S. E. Viral-induced hemolysis in equine infectious anemia. Am J Vet Res. 1969 Dec;30(12):2091–2097. [PubMed] [Google Scholar]
  15. McGuire T. C., Poppie M. J. Hypogammaglobulinemia and thymic hypoplasia in horses: a primary combined immunodeficiency disorder. Infect Immun. 1973 Aug;8(2):272–277. doi: 10.1128/iai.8.2.272-277.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. O'Rourke K., Perryman L. E., McGuire T. C. Antiviral, anti-glycoprotein and neutralizing antibodies in foals with equine infectious anaemia virus. J Gen Virol. 1988 Mar;69(Pt 3):667–674. doi: 10.1099/0022-1317-69-3-667. [DOI] [PubMed] [Google Scholar]
  17. Perryman L. E., McGuire T. C., Banks K. L., Henson J. B. Decreased C3 levels in a chronic virus infection: equine infectious anemia. J Immunol. 1971 Apr;106(4):1074–1078. [PubMed] [Google Scholar]
  18. Perryman L. E., McGuire T. C., Crawford T. B. Maintenance of foals with combined immunodeficiency: causes and control of secondary infections. Am J Vet Res. 1978 Jun;39(6):1043–1047. [PubMed] [Google Scholar]
  19. Perryman L. E., Torbeck R. L. Combined immunodeficiency of Arabian horses: confirmation of autosomal recessive mode of inheritance. J Am Vet Med Assoc. 1980 Jun 1;176(11):1250–1251. [PubMed] [Google Scholar]
  20. Sonigo P., Alizon M., Staskus K., Klatzmann D., Cole S., Danos O., Retzel E., Tiollais P., Haase A., Wain-Hobson S. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell. 1985 Aug;42(1):369–382. doi: 10.1016/s0092-8674(85)80132-x. [DOI] [PubMed] [Google Scholar]
  21. Stephens R. M., Casey J. W., Rice N. R. Equine infectious anemia virus gag and pol genes: relatedness to visna and AIDS virus. Science. 1986 Feb 7;231(4738):589–594. doi: 10.1126/science.3003905. [DOI] [PubMed] [Google Scholar]
  22. Stowring L., Haase A. T., Charman H. P. Serological definition of the lentivirus group of retroviruses. J Virol. 1979 Feb;29(2):523–528. doi: 10.1128/jvi.29.2.523-528.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wyatt C. R., Magnuson N. S., Perryman L. E. Defective thymocyte maturation in horses with severe combined immunodeficiency. J Immunol. 1987 Dec 15;139(12):4072–4076. [PubMed] [Google Scholar]
  24. Yaniv A., Dahlberg J. E., Tronick S. R., Chiu I. M., Aaronson S. A. Molecular cloning of integrated caprine arthritis-encephalitis virus. Virology. 1985 Sep;145(2):340–345. doi: 10.1016/0042-6822(85)90169-2. [DOI] [PubMed] [Google Scholar]

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