Skip to main content
PMC home page
Bulletin of the World Health Organization logoLink to Bulletin of the World Health Organization
. 1958;19(1):129–152.

The present status of laboratory research in trachoma

Phillips Thygeson
PMCID: PMC2537690  PMID: 13585065

Abstract

The present status of laboratory research in trachoma is summarized. The principal factors which have retarded research on this disease have been the lack of a suitable experimental animal and the failure of tissue-culture methods to provide serial cultures of the virus. Some avenues of investigation for the future are suggested.

Full text

PDF
131

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGARWAL L. P., SAXENA R. P. Conjunctival smear cytology in trachoma. Ophthalmologica. 1955 Feb;129(2):93–98. doi: 10.1159/000302480. [DOI] [PubMed] [Google Scholar]
  2. BABUDIERI B., BIETTI G. B., PANNARALE M. R. Ulteriori contributi sull'esistenza di affinità antigeniche fra gli agenti del tracoma e quelli del gruppo linfogranuloma venereopsittacosi. Rend Ist Sup Sanit. 1955;18(10):849–853. [PubMed] [Google Scholar]
  3. BEDSON S. P. Recent work on the viruses of the psittacosis-lymphogranuloma group and its importance with special reference to primary atypical pneumonia. Ir J Med Sci. 1952 Oct;(322):385–397. doi: 10.1007/BF02956958. [DOI] [PubMed] [Google Scholar]
  4. BIETTI G. Some contributions to the problems of trachoma. Rev Int Trach. 1956;33(2):201–228. [PubMed] [Google Scholar]
  5. CHAMS, MOHSENINE, ARMINE Inoculation expérimentale du trachome avec le produit broyé du tarse chez l'homme. Rev Int Trach. 1953;30(4):465–474. [PubMed] [Google Scholar]
  6. COONS A. H., KAPLAN M. H. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. J Exp Med. 1950 Jan 1;91(1):1–13. doi: 10.1084/jem.91.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. COONS A. H., LEDUC E. H., KAPLAN M. H. Localization of antigen in tissue cells. VI. The fate of injected foreign proteins in the mouse. J Exp Med. 1951 Feb;93(2):173–188. doi: 10.1084/jem.93.2.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CROCKER T. T., BENNETT B. M. Electron microscopic counting of elementary bodies of the virus of meningo-pneumonitis. J Immunol. 1952 Aug;69(2):183–196. [PubMed] [Google Scholar]
  9. CROCKER T. T., THYGESON P. Observations on experimental trachoma and inclusion conjunctivitis. Am J Ophthalmol. 1956 Oct;42(4 Pt 2):76–84. doi: 10.1016/0002-9394(56)90358-0. [DOI] [PubMed] [Google Scholar]
  10. Cuénod A., Nataf R. BACTERIOLOGICAL AND EXPERIMENTAL RESEARCHES ON THE AETIOLOGY OF TRACHOMA. Br J Ophthalmol. 1937 Jun;21(6):309–315. doi: 10.1136/bjo.21.6.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. FOWLE A. M., SIMMONS V., ORMSBY H. L. Adenoviruses from Canadian cases of keratoconjunctivitis. Am J Ophthalmol. 1957 Apr;43(4 Pt 2):32–35. doi: 10.1016/0002-9394(57)91473-3. [DOI] [PubMed] [Google Scholar]
  12. FUJIYAMA H. Study of trachoma virus; electron-microscopic study of the conjunctival suspension of human trachoma. Rev Int Trach. 1956;33(2):258–260. [PubMed] [Google Scholar]
  13. GIROUD P., RENOUX G. Mise en évidence d'anticorps locaux au niveau de la conjonctive infectée de trachome. C R Hebd Seances Acad Sci. 1956 Mar 19;242(12):1656–1658. [PubMed] [Google Scholar]
  14. GROSSFELD H. The nature of inclusion bodies in trachoma. Am J Ophthalmol. 1950 Dec;33(12):1831–1836. doi: 10.1016/0002-9394(50)90001-8. [DOI] [PubMed] [Google Scholar]
  15. ITO Y., ITO T., SASAKI Y. An electronmicroscopic study of the infective agent of trachoma. Br J Ophthalmol. 1951 Sep;35(9):553–559. doi: 10.1136/bjo.35.9.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Julianelle L. A. The antigenicity of the virus of trachoma. Am J Pathol. 1939 May;15(3):279–285. [PMC free article] [PubMed] [Google Scholar]
  17. KIMURA S. J., THYGESON P. The cytology of external ocular disease. Am J Ophthalmol. 1955 Feb;39(2 Pt 2):137–145. doi: 10.1016/0002-9394(55)90017-9. [DOI] [PubMed] [Google Scholar]
  18. MITSUI Y. Etiology of trachoma. Am J Ophthalmol. 1949 Sep;32(9):1189–1196. doi: 10.1016/s0002-9394(49)90972-1. [DOI] [PubMed] [Google Scholar]
  19. MITSUI Y., SUZUKI A. Electron microscopy of trachoma virus in section. AMA Arch Ophthalmol. 1956 Sep;56(3):429–448. doi: 10.1001/archopht.1956.00930040437011. [DOI] [PubMed] [Google Scholar]
  20. MITSUI Y., TANAKA C., YAMASHITA K., HANABUSA J. Toxin-like substance of trachoma virus. AMA Arch Ophthalmol. 1954 Jul;52(1):72–76. doi: 10.1001/archopht.1954.00920050074008. [DOI] [PubMed] [Google Scholar]
  21. MITSUI Y., TSUTSUI J., TANAKA C. Electron-microscopic study of Chlamydozoon trachomatis. Br J Ophthalmol. 1952 Oct;36(10):582–585. doi: 10.1136/bjo.36.10.582. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. ORMSBY H. L., THOMPSON G. A., COUSINEAU G. G., LLOYD L. A., HASSARD J. Topical therapy in inclusion conjunctivitis. Am J Ophthalmol. 1952 Dec;35(12):1811–1814. doi: 10.1016/0002-9394(52)92022-9. [DOI] [PubMed] [Google Scholar]
  23. POLEFF L. Culture des corps du trachome in vitro et dans l'oeuf incubé de poule. Arch Ophtalmol Rev Gen Ophtalmol. 1950;10(2):202–211. [PubMed] [Google Scholar]
  24. POLEFF L. Etat actuel des principaux problèmes de trachomatologie expérimentale. Rev Int Trach. 1954;31(4):434–483. [PubMed] [Google Scholar]
  25. POLEFF L. Simple and rapid contrast staining of trachoma bodies. Am J Ophthalmol. 1952 May;35(5 1):627–629. doi: 10.1016/0002-9394(52)90936-7. [DOI] [PubMed] [Google Scholar]
  26. Rake G., Jones H. P. STUDIES ON LYMPHOGRANULOMA VENEREUM : II. THE ASSOCIATION OF SPECIFIC TOXINS WITH AGENTS OF THE LYMPHOGRANULOMA-PSITTACOSIS GROUP. J Exp Med. 1944 May 1;79(5):463–486. doi: 10.1084/jem.79.5.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SEZER F. N. The cytology of trachoma. Am J Ophthalmol. 1951 Dec;34(12):1709–1713. doi: 10.1016/0002-9394(51)90037-2. [DOI] [PubMed] [Google Scholar]
  28. SIE-BOEN-LIAN Poleff's epithelial inclusion bodies. Rev Int Trach. 1955;32(2):177–184. [PubMed] [Google Scholar]
  29. STEWART F. H., BADIR G. Experiments on the cultivation of trachoma virus in the chick embryo. J Pathol Bacteriol. 1950 Jul;62(3):457–460. doi: 10.1002/path.1700620325. [DOI] [PubMed] [Google Scholar]
  30. TABORISKY Sur le diagnostic microscopique au début et à la fin du trachome. Rev Int Trach. 1952;29(4):351–359. [PubMed] [Google Scholar]
  31. THYGESON P. Acute trachoma. Arch Ophthal. 1949 Nov;42(5):655-65, illust. doi: 10.1001/archopht.1949.00900050665015. [DOI] [PubMed] [Google Scholar]
  32. THYGESON P. Criteria of cure in trachoma, with special reference to provocative tests. Rev Int Trach. 1953;30(4):450–464. [PubMed] [Google Scholar]
  33. TSUTSUI J., TAKEDA S. Recherches sur le trachome chlamidozoon au moyen du microscope électronique. Rev Int Trach. 1955;32(2):233–246. [PubMed] [Google Scholar]
  34. Thygeson P. The matrix of the epithelial cell inclusion body of trachoma. Am J Pathol. 1938 Jul;14(4):455–462.1. [PMC free article] [PubMed] [Google Scholar]
  35. WELLER T. H., COONS A. H. Fluorescent antibody studies with agents of varicella and herpes zoster propagated in vitro. Proc Soc Exp Biol Med. 1954 Aug-Sep;86(4):789–794. doi: 10.3181/00379727-86-21235. [DOI] [PubMed] [Google Scholar]
  36. Wolbach S. B., McKee S. H. The Nature of Trachoma Bodies. J Med Res. 1911 Apr;24(2):259–264.5. [PMC free article] [PubMed] [Google Scholar]

Articles from Bulletin of the World Health Organization are provided here courtesy of World Health Organization

RESOURCES