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. 1956;14(3):353–402.

Synthetic substances with morphine-like effect

Relationship between analgesic action and addiction liability, with a discussion of the chemical structure of addiction-producing substances*

Nathan B Eddy, H Halbach, Olav J Braenden
PMCID: PMC2538049  PMID: 13342924

Abstract

For compounds of the morphine, morphinan, pethidine, hexamethyleneimine, methadone, and dithienylbutenylamine groups, the analgesic and physical-dependence-producing properties are compared. On the basis of a parellelism in intensity of these properties, conclusions are drawn regarding their interrelationship and the chemical features common to substances with morphine-like addiction liability.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BACHRACH E. H., GODHOLM A. N., BETCHER A. M. Clinical observations on the use of alphaprodine (nisentil) for postoperative analgesia. Surgery. 1955 Mar;37(3):440–445. [PubMed] [Google Scholar]
  2. BRAENDEN O. J., EDDY N. B., HALBACH H. Synthetic substances with morphine-like effect; relationship between chemical structure and analgesic action. Bull World Health Organ. 1955;13(6):937–998. [PMC free article] [PubMed] [Google Scholar]
  3. BRAENDEN O. J., WOLFF P. O. Synthetic substances with morphine-like effect; chemical aspects. Bull World Health Organ. 1954;10(6):1003–1038. [PMC free article] [PubMed] [Google Scholar]
  4. DENTON J. E., BEECHER H. K. New analgesics. J Am Med Assoc. 1949 Dec 17;141(16):1146–1146. doi: 10.1001/jama.1949.62910160003009. [DOI] [PubMed] [Google Scholar]
  5. EDDY N. B., LEIMBACH D. Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. J Pharmacol Exp Ther. 1953 Mar;107(3):385–393. [PubMed] [Google Scholar]
  6. EDDY N. B., TOUCHBERRY C. F., LIEBERMAN J. E. Synthetic analgesics; methadone isomers and derivatives. J Pharmacol Exp Ther. 1950 Feb;98(2):121–137. [PubMed] [Google Scholar]
  7. FLINTAN P., KEELE C. A. Analgesic and other actions of some dithienylbutenlamine compounds in man. Br J Pharmacol Chemother. 1954 Mar;9(1):106–117. doi: 10.1111/j.1476-5381.1954.tb00826.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FRASER H. F., ISBELL H. Actions and addiction liabilities of alpha-acetyl-methadols in man. J Pharmacol Exp Ther. 1952 Aug;105(4):458–465. [PubMed] [Google Scholar]
  9. FRASER H. F., ISBELL H. Addiction liabilities of morphinan, 6-methyldihydromorphine and dihydrocodeinone. J Pharmacol Exp Ther. 1950 Oct;100(2):128–135. [PubMed] [Google Scholar]
  10. FRASER H. F., NASH T. L., VANHORN G. D., ISBELL H. Use of miotic effect in evaluating analgesic drugs in man. Arch Int Pharmacodyn Ther. 1954 Aug 1;98(4):443–451. [PubMed] [Google Scholar]
  11. HUNT R. D., FOLDES F. F. The use of levo-dromoran tartrate (levorphan tartrate) for relief of postoperative pain. N Engl J Med. 1953 May 7;248(19):803–805. doi: 10.1056/NEJM195305072481902. [DOI] [PubMed] [Google Scholar]
  12. ISBELL H., FRASER H. F. Actions and addiction liabilities of dromoran derivatives in man. J Pharmacol Exp Ther. 1953 Apr;107(4):524–530. [PubMed] [Google Scholar]
  13. ISBELL H., FRASER H. F. Actions and addition liability of the dithienylbutenylamines in man. J Pharmacol Exp Ther. 1953 Dec;109(4):417–421. [PubMed] [Google Scholar]
  14. ISBELL H. Nalline, a specific narcotic antagonist; clinical and pharmacologic observations. Merck Rep. 1953 Apr;62(2):23–26. [PubMed] [Google Scholar]
  15. ISBELL H. The addiction liability of some derivatives of meperidine. J Pharmacol Exp Ther. 1949 Oct;97(2):182–189. [PubMed] [Google Scholar]
  16. ISBELL H., VOGEL V. H. The addiction liability of methadon (amidone, dolophine, 10820) and its use in the treatment of the morphine abstinence syndrome. Am J Psychiatry. 1949 Jun;105(12):909–914. doi: 10.1176/ajp.105.12.909. [DOI] [PubMed] [Google Scholar]
  17. JAGGARD R. S., ZAGER L. L., WILKINS D. S. Clinical evaluation of analgesic drugs. A comparison of Nu-2206 and Morphine sulfate administered to postoperative patients. AMA Arch Surg. 1950 Dec;61(6):1073–1082. [PubMed] [Google Scholar]
  18. KEATS A. S., BEECHER H. K. Analgesic potency and side action liability in man of heptazone, WIN 1161-2, 6-methyl dihydromorphine, Metopon, levo-isomethadone and pentobarbital sodium, as a further effort to refine methods of evaluation of analgesic drugs. J Pharmacol Exp Ther. 1952 Jun;105(2):109–129. [PubMed] [Google Scholar]
  19. LASAGNA L., BEECHER H. K. The analgesic effectiveness of codeine and meperidine (demerol). J Pharmacol Exp Ther. 1954 Nov;112(3):306–311. [PubMed] [Google Scholar]
  20. LASAGNA L., BEECHER H. K. The analgesic effectiveness of nalorphine and nalorphine-morphine combinations in man. J Pharmacol Exp Ther. 1954 Nov;112(3):356–363. [PubMed] [Google Scholar]
  21. LEIMBACH D. G., EDDY N. B. Synthetic analgesics: III. Methadols, isomethadols, and their acyl derivatives. J Pharmacol Exp Ther. 1954 Feb;110(2):135–147. [PubMed] [Google Scholar]
  22. LINDER F., VOLLMAR J. Klinische Erfahrungen mit dem synthetischen Analgeticum Cliradon (Ciba 7115) mit vergleichenden Untersuchungen über seine Wirkung auf Atmung, Kreislauf und Wärmehaushalt. Klin Wochenschr. 1950 Oct 15;28(39-40):675–681. doi: 10.1007/BF01485601. [DOI] [PubMed] [Google Scholar]
  23. RECHENBERG H. K., ZEERLEDER R. Klinische Erfahrungen mit Dromoran [(-)-3-Oxy-N-methyl-morphinan-tartrat], einem neuen synthetischen Analgeticum. Schweiz Med Wochenschr. 1951 Nov 3;81(44):1086–1089. [PubMed] [Google Scholar]
  24. SLOMKA M. B., GROSS E. G. An evaluation of the analgetic activity of the dromoran isomers. Proc Soc Exp Biol Med. 1952 Nov;81(2):548–551. doi: 10.3181/00379727-81-19936. [DOI] [PubMed] [Google Scholar]
  25. SLOMKA M. B., SLEETH C. K. Analgetic activity of optical isomers of 3-hydroxy-N-methylmorphinan and 6-dimethylamino-4,4-diphenyl-3-heptanone. Proc Soc Exp Biol Med. 1953 Dec;84(3):532–534. doi: 10.3181/00379727-84-20702. [DOI] [PubMed] [Google Scholar]
  26. SMITH R. M. Clinical experience with dromoran hydrobromide (Nu 2206) for the relief of chronic pain. South Med Surg. 1950 Aug;112(8):251–252. [PubMed] [Google Scholar]

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