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. 1994 Feb 12;308(6926):441–443. doi: 10.1136/bmj.308.6926.441

Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Côte d'Ivoire.

K M De Cock 1, F Zadi 1, G Adjorlolo 1, M O Diallo 1, M Sassan-Morokro 1, E Ekpini 1, T Sibailly 1, R Doorly 1, V Batter 1, K Brattegaard 1, et al.
PMCID: PMC2539507  PMID: 8124173

Abstract

OBJECTIVES--To compare the effects of maternal HIV-1 and HIV-2 infections on outcome of pregnancy, infant mortality, and child survival, and to measure serological concordance between mothers and children. DESIGN--Retrospective cohort study with cross sectional study of concordance for HIV antibodies. SETTING--Hospital, tuberculosis clinic, and maternal and child health centre in Abidjan, Côte d'Ivoire, west Africa. SUBJECTS--986 women who had had a total of 2758 pregnancies since 1980. The last born children of 194 of these women. MAIN OUTCOME MEASURES--Pregnancy outcomes; mortality for all children born since 1980; and outcome for last born children. Serological concordance between mothers and last born children. RESULTS--Women with HIV-1 and HIV-2 infections had higher rates of spontaneous abortion and stillbirth than uninfected women (86/769 in HIV-1 positive women, 48/421 in HIV-2 positive, 31/234 in dually reactive, and 96/1131 in uninfected). Compared with children born to uninfected mothers (mortality 10.3%), greater proportions of children of HIV-1 positive (20.6%) and dually reactive (20.3%) mothers had died; mortality in children of HIV-2 infected women (13.1%) was not significantly increased. Infant mortalities for the last born children of HIV-1 positive, dually reactive, HIV-2 positive, and seronegative women were, respectively, 133, 82, 32, and 40 per 1000 live births. Nine of 77 last born children of HIV-1 positive mothers were concordantly seropositive compared with none of 21 children of HIV-2 infected mothers. CONCLUSIONS--Maternal HIV-2 infection has less influence on child survival than infection with HIV-1, probably because of a lower vertical transmission rate.

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Selected References

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  1. Andreasson P. A., Dias F., Nauclér A., Andersson S., Biberfeld G. A prospective study of vertical transmission of HIV-2 in Bissau, Guinea-Bissau. AIDS. 1993 Jul;7(7):989–993. [PubMed] [Google Scholar]
  2. Dabis F., Msellati P., Dunn D., Lepage P., Newell M. L., Peckham C., Van de Perre P. Estimating the rate of mother-to-child transmission of HIV. Report of a workshop on methodological issues Ghent (Belgium), 17-20 February 1992. The Working Group on Mother-to-Child Transmission of HIV. AIDS. 1993 Aug;7(8):1139–1148. doi: 10.1097/00002030-199308000-00027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. De Cock K. M., Adjorlolo G., Ekpini E., Sibailly T., Kouadio J., Maran M., Brattegaard K., Vetter K. M., Doorly R., Gayle H. D. Epidemiology and transmission of HIV-2. Why there is no HIV-2 pandemic. JAMA. 1993 Nov 3;270(17):2083–2086. doi: 10.1001/jama.270.17.2083. [DOI] [PubMed] [Google Scholar]
  4. De Cock K. M., Barrere B., Diaby L., Lafontaine M. F., Gnaore E., Porter A., Pantobe D., Lafontant G. C., Dago-Akribi A., Ette M. AIDS--the leading cause of adult death in the West African City of Abidjan, Ivory Coast. Science. 1990 Aug 17;249(4970):793–796. doi: 10.1126/science.2167515. [DOI] [PubMed] [Google Scholar]
  5. De Cock K. M., Brun-Vézinet F. Epidemiology of HIV-2 infection. AIDS. 1989;3 (Suppl 1):S89–S95. doi: 10.1097/00002030-198901001-00013. [DOI] [PubMed] [Google Scholar]
  6. De Cock K. M., Brun-Vézinet F., Soro B. HIV-1 and HIV-2 infections and AIDS in West Africa. AIDS. 1991;5 (Suppl 1):S21–S28. [PubMed] [Google Scholar]
  7. De Cock K. M., Odehouri K., Colebunders R. L., Adjorlolo G., Lafontaine M. F., Porter A., Gnaore E., Diaby L., Moreau J., Heyward W. L. A comparison of HIV-1 and HIV-2 infections in hospitalized patients in Abidjan, Côte d'Ivoire. AIDS. 1990 May;4(5):443–448. doi: 10.1097/00002030-199005000-00010. [DOI] [PubMed] [Google Scholar]
  8. De Cock K. M., Porter A., Kouadio J., Maran M., Gnaore E., Adjorlolo G., Lafontaine M. F., Bretton G., Damet G. M., Odehouri K. Rapid and specific diagnosis of HIV-1 and HIV-2 infections: an evaluation of testing strategies. AIDS. 1990 Sep;4(9):875–878. doi: 10.1097/00002030-199009000-00007. [DOI] [PubMed] [Google Scholar]
  9. De Cock K. M., Porter A., Odehouri K., Barrere B., Moreau J., Diaby L., Kouadio J. C., Heyward W. L. Rapid emergence of AIDS in Abidjan, Ivory Coast. Lancet. 1989 Aug 19;2(8660):408–411. doi: 10.1016/s0140-6736(89)90590-4. [DOI] [PubMed] [Google Scholar]
  10. Del Mistro A., Chotard J., Hall A. J., Whittle H., De Rossi A., Chieco-Bianchi L. HIV-1 and HIV-2 seroprevalence rates in mother-child pairs living in The Gambia (west Africa). J Acquir Immune Defic Syndr. 1992;5(1):19–24. [PubMed] [Google Scholar]
  11. Gayle H. D., Gnaore E., Adjorlolo G., Ekpini E., Coulibaly R., Porter A., Braun M. M., Zabban M. L., Andou J., Timite A. HIV-1 and HIV-2 infection in children in Abidjan, Côte d'Ivoire. J Acquir Immune Defic Syndr. 1992;5(5):513–517. [PubMed] [Google Scholar]
  12. George J. R., Ou C. Y., Parekh B., Brattegaard K., Brown V., Boateng E., De Cock K. M. Prevalence of HIV-1 and HIV-2 mixed infections in Côte d'Ivoire. Lancet. 1992 Aug 8;340(8815):337–339. doi: 10.1016/0140-6736(92)91406-x. [DOI] [PubMed] [Google Scholar]
  13. Gnaore E., De Cock K. M., Gayle H., Porter A., Coulibaly R., Timite M., Assi-Adou J., Heyward W. L. Prevalence of and mortality from HIV type 2 in Guinea Bissau, West Africa. Lancet. 1989 Aug 26;2(8661):513–513. doi: 10.1016/s0140-6736(89)92132-6. [DOI] [PubMed] [Google Scholar]
  14. Halsey N. A., Boulos R., Holt E., Ruff A., Brutus J. R., Kissinger P., Quinn T. C., Coberly J. S., Adrien M., Boulos C. Transmission of HIV-1 infections from mothers to infants in Haiti. Impact on childhood mortality and malnutrition. The CDS/JHU AIDS Project Team. JAMA. 1990 Oct 24;264(16):2088–2092. [PubMed] [Google Scholar]
  15. Lallemant M., Lallemant-Le-Coeur S., Cheynier D., Nzingoula S., Jourdain G., Sinet M., Dazza M. C., Blanche S., Griscelli C., Larouzé B. Mother-child transmission of HIV-1 and infant survival in Brazzaville, Congo. AIDS. 1989 Oct;3(10):643–646. doi: 10.1097/00002030-198910000-00004. [DOI] [PubMed] [Google Scholar]
  16. Matheron S., Courpotin C., Simon F., Di Maria H., Balloul H., Bartzack S., Dormont D., Brun Vezinet F., Saimot A. G., Coulaud J. P. Vertical transmission of HIV-2. Lancet. 1990 May 5;335(8697):1103–1104. doi: 10.1016/0140-6736(90)92682-8. [DOI] [PubMed] [Google Scholar]
  17. Miotti P. G., Dallabetta G. A., Chiphangwi J. D., Liomba G., Saah A. J. A retrospective study of childhood mortality and spontaneous abortion in HIV-1 infected women in urban Malawi. Int J Epidemiol. 1992 Aug;21(4):792–799. doi: 10.1093/ije/21.4.792. [DOI] [PubMed] [Google Scholar]
  18. Miotti P. G., Dallabetta G., Ndovi E., Liomba G., Saah A. J., Chiphangwi J. HIV-1 and pregnant women: associated factors, prevalence, estimate of incidence and role in fetal wastage in central Africa. AIDS. 1990 Aug;4(8):733–736. [PubMed] [Google Scholar]
  19. Morgan G., Wilkins H. A., Pepin J., Jobe O., Brewster D., Whittle H. AIDS following mother-to-child transmission of HIV-2. AIDS. 1990 Sep;4(9):879–882. doi: 10.1097/00002030-199009000-00008. [DOI] [PubMed] [Google Scholar]
  20. Peeters M., Gershy-Damet G. M., Fransen K., Koffi K., Coulibaly M., Delaporte E., Piot P., van der Groen G. Virological and polymerase chain reaction studies of HIV-1/HIV-2 dual infection in Côte d'Ivoire. Lancet. 1992 Aug 8;340(8815):339–340. doi: 10.1016/0140-6736(92)91407-y. [DOI] [PubMed] [Google Scholar]
  21. Poulsen A. G., Kvinesdal B. B., Aaby P., Lisse I. M., Gottschau A., Mølbak K., Dias F., Lauritzen E. Lack of evidence of vertical transmission of human immunodeficiency virus type 2 in a sample of the general population in Bissau. J Acquir Immune Defic Syndr. 1992;5(1):25–30. [PubMed] [Google Scholar]
  22. Rayfield M., De Cock K., Heyward W., Goldstein L., Krebs J., Kwok S., Lee S., McCormick J., Moreau J. M., Odehouri K. Mixed human immunodeficiency virus (HIV) infection in an individual: demonstration of both HIV type 1 and type 2 proviral sequences by using polymerase chain reaction. J Infect Dis. 1988 Dec;158(6):1170–1176. doi: 10.1093/infdis/158.6.1170. [DOI] [PubMed] [Google Scholar]
  23. Ryder R. W., Nsa W., Hassig S. E., Behets F., Rayfield M., Ekungola B., Nelson A. M., Mulenda U., Francis H., Mwandagalirwa K. Perinatal transmission of the human immunodeficiency virus type 1 to infants of seropositive women in Zaire. N Engl J Med. 1989 Jun 22;320(25):1637–1642. doi: 10.1056/NEJM198906223202501. [DOI] [PubMed] [Google Scholar]
  24. Temmerman M., Plummer F. A., Mirza N. B., Ndinya-Achola J. O., Wamola I. A., Nagelkerke N., Brunham R. C., Piot P. Infection with HIV as a risk factor for adverse obstetrical outcome. AIDS. 1990 Nov;4(11):1087–1093. doi: 10.1097/00002030-199011000-00006. [DOI] [PubMed] [Google Scholar]

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