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. 1994 May 7;308(6938):1213–1217. doi: 10.1136/bmj.308.6938.1213

Management of variceal haemorrhage.

S G Williams 1, D Westaby 1
PMCID: PMC2540071  PMID: 8180541

Abstract

Fig 2 gives an algorithm for the treatment of bleeding oesophageal varices. Initial resuscitation of the patient is of paramount importance, ideally followed by early interventional endoscopy. Recent advances in available endoscopic techniques enable the endoscopist to suit the therapeutic approach to the clinical situation. Injection sclerotherapy remains the initial treatment of choice in bleeding patients. Endoscopic banding ligation is an alternative, best used in patients who have spontaneously stopped bleeding or as a complementary treatment a few days after the initial session of injection sclerotherapy. The tissue adhesives and thrombin can be used to treat bleeding gastric varices. [table: see text] Should the endoscopic expertise not be available, drug treatment (with somatostatin or octreotide) or balloon tamponade are the treatments of choice. Transjugular intrahepatic portal-systemic stent shunt is a new effective technique, not yet widely available, which has a documented complication rate that has yet to be fully defined. It is a good alternative to surgery as a "rescue" procedure for patients who continue to bleed despite two sessions of endoscopic intervention.

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Selected References

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  1. Bosch J., Navasa M., Garcia-Pagán J. C., DeLacy A. M., Rodés J. Portal hypertension. Med Clin North Am. 1989 Jul;73(4):931–953. doi: 10.1016/s0025-7125(16)30646-0. [DOI] [PubMed] [Google Scholar]
  2. Burroughs A. K. Medical management of bleeding esophageal varices. Dig Dis. 1992;10 (Suppl 1):30–37. doi: 10.1159/000171385. [DOI] [PubMed] [Google Scholar]
  3. Calès P., Pascal J. P. Histoire naturelle des varices oesophagiennes au cours de la cirrhose (de la naissance à la rupture). Gastroenterol Clin Biol. 1988 Mar;12(3):245–254. [PubMed] [Google Scholar]
  4. Christensen E., Fauerholdt L., Schlichting P., Juhl E., Poulsen H., Tygstrup N. Aspects of the natural history of gastrointestinal bleeding in cirrhosis and the effect of prednisone. Gastroenterology. 1981 Nov;81(5):944–952. [PubMed] [Google Scholar]
  5. Conn H. O. Transjugular intrahepatic portal-systemic shunts: the state of the art. Hepatology. 1993 Jan;17(1):148–158. [PubMed] [Google Scholar]
  6. Fleischer D. Etiology and prevalence of severe persistent upper gastrointestinal bleeding. Gastroenterology. 1983 Mar;84(3):538–543. [PubMed] [Google Scholar]
  7. Hasan F., Levine B. A. The role of endoscopic sclerotherapy in the management of esophageal varices. Dig Dis. 1992;10 (Suppl 1):38–45. doi: 10.1159/000171386. [DOI] [PubMed] [Google Scholar]
  8. Iwatsuki S., Starzl T. E. Liver transplantation in the management of bleeding oesophageal varices. Baillieres Clin Gastroenterol. 1992 Sep;6(3):517–525. doi: 10.1016/0950-3528(92)90036-e. [DOI] [PubMed] [Google Scholar]
  9. McKee R. A study of octreotide in oesophageal varices. Digestion. 1990;45 (Suppl 1):60–65. doi: 10.1159/000200264. [DOI] [PubMed] [Google Scholar]
  10. Panés J., Terés J., Bosch J., Rodés J. Efficacy of balloon tamponade in treatment of bleeding gastric and esophageal varices. Results in 151 consecutive episodes. Dig Dis Sci. 1988 Apr;33(4):454–459. doi: 10.1007/BF01536031. [DOI] [PubMed] [Google Scholar]
  11. Perrillo R. P. Hepatitis B: transmission and natural history. Gut. 1993;34(2 Suppl):S48–S49. doi: 10.1136/gut.34.2_suppl.s48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Polson R. J., Westaby D., Gimson A. E., Hayes P. C., Stellon A. J., Hayllar K., Williams R. Sucralfate for the prevention of early rebleeding following injection sclerotherapy for esophageal varices. Hepatology. 1989 Sep;10(3):279–282. doi: 10.1002/hep.1840100304. [DOI] [PubMed] [Google Scholar]
  13. Ramond M. J., Valla D., Mosnier J. F., Degott C., Bernuau J., Rueff B., Benhamou J. P. Successful endoscopic obturation of gastric varices with butyl cyanoacrylate. Hepatology. 1989 Oct;10(4):488–493. doi: 10.1002/hep.1840100415. [DOI] [PubMed] [Google Scholar]
  14. Shemesh E., Czerniak A., Klein E., Pines A., Bat L. A comparison between emergency and delayed endoscopic injection sclerotherapy of bleeding esophageal varices in nonalcoholic portal hypertension. J Clin Gastroenterol. 1990 Feb;12(1):5–9. doi: 10.1097/00004836-199002000-00003. [DOI] [PubMed] [Google Scholar]
  15. Shields R., Jenkins S. A., Baxter J. N., Kingsnorth A. N., Ellenbogen S., Makin C. A., Gilmore I., Morris A. I., Ashby D., West C. R. A prospective randomised controlled trial comparing the efficacy of somatostatin with injection sclerotherapy in the control of bleeding oesophageal varices. J Hepatol. 1992 Sep;16(1-2):128–137. doi: 10.1016/s0168-8278(05)80105-9. [DOI] [PubMed] [Google Scholar]
  16. Smith T. NHS: a time to choose. BMJ. 1989 Jan 7;298(6665):1–2. doi: 10.1136/bmj.298.6665.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Stiegmann G. V., Goff J. S., Michaletz-Onody P. A., Korula J., Lieberman D., Saeed Z. A., Reveille R. M., Sun J. H., Lowenstein S. R. Endoscopic sclerotherapy as compared with endoscopic ligation for bleeding esophageal varices. N Engl J Med. 1992 Jun 4;326(23):1527–1532. doi: 10.1056/NEJM199206043262304. [DOI] [PubMed] [Google Scholar]
  18. Sung J. J., Chung S. C., Lai C. W., Chan F. K., Leung J. W., Yung M. Y., Kassianides C., Li A. K. Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Lancet. 1993 Sep 11;342(8872):637–641. doi: 10.1016/0140-6736(93)91758-e. [DOI] [PubMed] [Google Scholar]
  19. Sée A., Florent C., Lamy P., Lévy V. G., Bouvry M. Accidents vasculaires cérébraux après obturation endoscopique des varices oesophagiennes par l'isobutyl-2-cyanoacrylate chez deux malades. Gastroenterol Clin Biol. 1986 Aug-Sep;10(8-9):604–607. [PubMed] [Google Scholar]
  20. Terblanche J., Burroughs A. K., Hobbs K. E. Controversies in the management of bleeding esophageal varices (1) N Engl J Med. 1989 May 25;320(21):1393–1398. doi: 10.1056/NEJM198905253202107. [DOI] [PubMed] [Google Scholar]
  21. Terblanche J., Yakoob H. I., Bornman P. C., Stiegmann G. V., Bane R., Jonker M., Wright J., Kirsch R. Acute bleeding varices: a five-year prospective evaluation of tamponade and sclerotherapy. Ann Surg. 1981 Oct;194(4):521–530. doi: 10.1097/00000658-198110000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Westaby D., Hayes P. C., Gimson A. E., Polson R. J., Williams R. Controlled clinical trial of injection sclerotherapy for active variceal bleeding. Hepatology. 1989 Feb;9(2):274–277. doi: 10.1002/hep.1840090219. [DOI] [PubMed] [Google Scholar]

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