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. 1994 Jun 4;308(6942):1473–1476. doi: 10.1136/bmj.308.6942.1473

Smoking during pregnancy and congenital limb deficiency.

A E Czeizel 1, I Kodaj 1, W Lenz 1
PMCID: PMC2540321  PMID: 8019281

Abstract

OBJECTIVE--To examine genetic and environmental factors in the origin of isolated congenital limb deficiencies. DESIGN--Case-control study with questionnaire at a family interview of cases of isolated congenital limb deficiencies (six types), negative controls (matched for age, sex, and place of residence), and positive controls (cases of sentinel anomalies). SETTING--The database of the Hungarian Congenital Abnormality Registry, 1975-84, complemented by three other sources of ascertainment (1,575,904 births). SUBJECTS--537 case-control pairs; 392 positive controls. MAIN OUTCOME MEASURES--Smoking during pregnancy, congenital limb deficiencies. RESULTS--The adjusted rate of smoking during pregnancy was significantly higher in the mothers of cases of terminal transverse defect (relative odds 1.48; 95% confidence interval 0.98 to 2.23; P = 0.017). This finding supports the hypothesis of vascular disruption as a cause of congenital limb deficiency. CONCLUSIONS--Maternal smoking during pregnancy raises the relative odds for terminal transverse limb deficiencies.

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Selected References

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  1. Aro T., Haapakoski J., Heinonen O. P. A multivariate analysis of the risk indicators of reduction limb defects. Int J Epidemiol. 1984 Dec;13(4):459–464. doi: 10.1093/ije/13.4.459. [DOI] [PubMed] [Google Scholar]
  2. Aro T. Maternal diseases, alcohol consumption and smoking during pregnancy associated with reduction limb defects. Early Hum Dev. 1983 Dec;9(1):49–57. doi: 10.1016/0378-3782(83)90101-9. [DOI] [PubMed] [Google Scholar]
  3. Breslow N. E., Day N. E., Halvorsen K. T., Prentice R. L., Sabai C. Estimation of multiple relative risk functions in matched case-control studies. Am J Epidemiol. 1978 Oct;108(4):299–307. doi: 10.1093/oxfordjournals.aje.a112623. [DOI] [PubMed] [Google Scholar]
  4. Bély M., Apáthy A., Pintér T., Ratkó J. Generalized secondary amyloidosis in rheumatoid arthritis. Acta Morphol Hung. 1992;40(1-4):49–69. [PubMed] [Google Scholar]
  5. Czeizel A. E., Vitéz M., Kodaj I., Lenz W. A morphological and family study on isolated terminal transverse type of congenital limb deficiency in Hungary, 1975-1984. Teratology. 1993 Oct;48(4):323–327. doi: 10.1002/tera.1420480405. [DOI] [PubMed] [Google Scholar]
  6. Czeizel A. E., Vitéz M., Kodaj I., Lenz W. An epidemiological study of isolated split hand/foot in Hungary, 1975-1984. J Med Genet. 1993 Jul;30(7):593–596. doi: 10.1136/jmg.30.7.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Czeizel A. E., Vitéz M., Kodaj I., Lenz W. Causal study of isolated ulnar-fibular deficiency in Hungary, 1975-1984. Am J Med Genet. 1993 Jun 1;46(4):427–433. doi: 10.1002/ajmg.1320460416. [DOI] [PubMed] [Google Scholar]
  8. Czeizel A. E., Vitéz M., Kodaj I., Lenz W. Study of isolated apparent amniogenic limb deficiency in Hungary, 1975-1984. Am J Med Genet. 1993 Jun 1;46(4):372–378. doi: 10.1002/ajmg.1320460406. [DOI] [PubMed] [Google Scholar]
  9. Czeizel A. Are contraceptive pills teratogenic? Acta Morphol Acad Sci Hung. 1980;28(1-2):177–188. [PubMed] [Google Scholar]
  10. Czeizel A. Population surveillance of sentinel anomalies. Mutat Res. 1989 May;212(1):3–9. doi: 10.1016/0027-5107(89)90017-1. [DOI] [PubMed] [Google Scholar]
  11. Czeizel A. The activities of the Hungarian Centre for Congenital Anomaly Control. World Health Stat Q. 1988;41(3-4):219–227. [PubMed] [Google Scholar]
  12. Czeizel A., Vitéz M., Kodaj I., Lenz W. Birth prevalence of different congenital limb deficiency types in a revised, population based Hungarian material, 1975-1984. Acta Morphol Hung. 1991;39(3):229–237. [PubMed] [Google Scholar]
  13. Firth H. V., Boyd P. A., Chamberlain P., MacKenzie I. Z., Lindenbaum R. H., Huson S. M. Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation. Lancet. 1991 Mar 30;337(8744):762–763. doi: 10.1016/0140-6736(91)91374-4. [DOI] [PubMed] [Google Scholar]
  14. Holford T. R., White C., Kelsey J. L. Multivariate analysis for matched case-control studies. Am J Epidemiol. 1978 Mar;107(3):245–256. doi: 10.1093/oxfordjournals.aje.a112531. [DOI] [PubMed] [Google Scholar]
  15. Kóbor J., Pejtsik B., Járai I., Pados E., Horváth M., Csébfalvi G. Terhesség alatti dohányzás hatása a születési súlypercentilis értékek alakulására. Orv Hetil. 1988 Jan 3;129(1):21–23. [PubMed] [Google Scholar]
  16. Landis J. R., Koch G. G. The measurement of observer agreement for categorical data. Biometrics. 1977 Mar;33(1):159–174. [PubMed] [Google Scholar]
  17. Limb-reduction defects and chorion villus sampling. Lancet. 1991 May 4;337(8749):1091–1092. doi: 10.1016/0140-6736(91)91735-D. [DOI] [PubMed] [Google Scholar]
  18. Mackenzie S. G., Lippman A. An investigation of report bias in a case-control study of pregnancy outcome. Am J Epidemiol. 1989 Jan;129(1):65–75. doi: 10.1093/oxfordjournals.aje.a115125. [DOI] [PubMed] [Google Scholar]
  19. Menges R. W., Selby L. A., Marienfeld C. J., Aue W. A., Greer D. L. A tobacco related epidemic of congenital limb deformities in swine. Environ Res. 1970 Nov;3(4):285–302. doi: 10.1016/0013-9351(70)90022-8. [DOI] [PubMed] [Google Scholar]
  20. Oakley A., Rajan L., Robertson P. A comparison of different sources of information about pregnancy and childbirth. J Biosoc Sci. 1990 Oct;22(4):477–487. doi: 10.1017/s0021932000018885. [DOI] [PubMed] [Google Scholar]
  21. Olsen J., Frische G. Comparison between data obtained through questionnaires and interviews: life-style habits of pregnant women. Scand J Soc Med. 1988;16(1):49–52. doi: 10.1177/140349488801600108. [DOI] [PubMed] [Google Scholar]
  22. Shiono P. H., Klebanoff M. A., Berendes H. W. Congenital malformations and maternal smoking during pregnancy. Teratology. 1986 Aug;34(1):65–71. doi: 10.1002/tera.1420340109. [DOI] [PubMed] [Google Scholar]

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