Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1985 May;54(2):304–310. doi: 10.1128/jvi.54.2.304-310.1985

Induction of angiosarcoma by a c-erbB transducing virus.

S E Tracy, B A Woda, H L Robinson
PMCID: PMC254798  PMID: 2985799

Abstract

Recently, 12 new transductions of c-erbB have been identified in a series of Rous-associated virus type 1-induced erythroleukemias. During the passage of these new transducing viruses it has become apparent that the erythroleukemia in chicken 5005 contained two different c-erbB transducing viruses. One induces erythroblastosis, whereas the second induces angiosarcoma. The angiosarcoma- and erythroblastosis-inducing viruses appear to have had a common ancestor, since tumors induced by each contain a novel, 4.3-kilobase c-erbB-related EcoRI fragment. The angiosarcoma-inducing virus has been named avian angiosarcoma virus and is designated for the chicken in which it originated.

Full text

PDF
305

Images in this article

306Image
on p.306
306Image
on p.306
307Image
on p.307
307Image
on p.307
308Image
on p.308
309Image
on p.309

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J., Waterfield M. D. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature. 1984 Feb 9;307(5951):521–527. doi: 10.1038/307521a0. [DOI] [PubMed] [Google Scholar]
  2. Frykberg L., Palmieri S., Beug H., Graf T., Hayman M. J., Vennström B. Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenes. Cell. 1983 Jan;32(1):227–238. doi: 10.1016/0092-8674(83)90513-5. [DOI] [PubMed] [Google Scholar]
  3. Gazzolo L., Moscovici C., Moscovici M. G., Samarut J. Response of hemopoietic cells to avian acute leukemia viruses: effects on the differentiation of the target cells. Cell. 1979 Mar;16(3):627–638. doi: 10.1016/0092-8674(79)90036-9. [DOI] [PubMed] [Google Scholar]
  4. Graf T., Fink D., Beug H., Royer-Pokora B. Oncornavirus-induced sarcoma formation obscured by rapid development of lethal leukemia. Cancer Res. 1977 Jan;37(1):59–63. [PubMed] [Google Scholar]
  5. Graf T., Royer-Pokora B., Schubert G. E., Beug H. Evidence for the multiple oncogenic potential of cloned leukemia virus: in vitro and in vitro studies with avian erythroblastosis virus. Virology. 1976 Jun;71(2):423–433. doi: 10.1016/0042-6822(76)90370-6. [DOI] [PubMed] [Google Scholar]
  6. Graf T., von Kirchbach A., Beug H. Characterization of the hematopoietic target cells of AEV, MC29 and AMV avian leukemia viruses. Exp Cell Res. 1981 Feb;131(2):331–343. doi: 10.1016/0014-4827(81)90236-6. [DOI] [PubMed] [Google Scholar]
  7. Hayman M. J., Beug H. Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface. 1984 May 31-Jun 6Nature. 309(5967):460–462. doi: 10.1038/309460a0. [DOI] [PubMed] [Google Scholar]
  8. Hayman M. J., Ramsay G. M., Savin K., Kitchener G., Graf T., Beug H. Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein. Cell. 1983 Feb;32(2):579–588. doi: 10.1016/0092-8674(83)90477-4. [DOI] [PubMed] [Google Scholar]
  9. Hihara H., Yamamoto H., Shimohira H., Arai K., Shimizu T. Avian erythroblastosis virus isolated from chick erythroblastosis induced by lymphatic leukemia virus subgroup A. J Natl Cancer Inst. 1983 May;70(5):891–897. [PubMed] [Google Scholar]
  10. Hughes S. H., Shank P. R., Spector D. H., Kung H. J., Bishop J. M., Varmus H. E., Vogt P. K., Breitman M. L. Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites. Cell. 1978 Dec;15(4):1397–1410. doi: 10.1016/0092-8674(78)90064-8. [DOI] [PubMed] [Google Scholar]
  11. Jaffe E. A. Endothelial cells and the biology of factor VIII. N Engl J Med. 1977 Feb 17;296(7):377–383. doi: 10.1056/NEJM197702172960707. [DOI] [PubMed] [Google Scholar]
  12. Miles B. D., Robinson H. L. High-frequency transduction of c-erbB in avian leukosis virus-induced erythroblastosis. J Virol. 1985 May;54(2):295–303. doi: 10.1128/jvi.54.2.295-303.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nishida T., Sakamoto S., Yamamoto T., Hayman M., Kawai S., Toyoshima K. Comparison of genome structures among three different strains of avian erythroblastosis virus. Gan. 1984 Apr;75(4):325–333. [PubMed] [Google Scholar]
  14. Privalsky M. L., Bishop J. M. Proteins specified by avian erythroblastosis virus: coding region localization and identification of a previously undetected erb-B polypeptide. Proc Natl Acad Sci U S A. 1982 Jul;79(13):3958–3962. doi: 10.1073/pnas.79.13.3958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Privalsky M. L., Ralston R., Bishop J. M. The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases. Proc Natl Acad Sci U S A. 1984 Feb;81(3):704–707. doi: 10.1073/pnas.81.3.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Privalsky M. L., Sealy L., Bishop J. M., McGrath J. P., Levinson A. D. The product of the avian erythroblastosis virus erbB locus is a glycoprotein. Cell. 1983 Apr;32(4):1257–1267. doi: 10.1016/0092-8674(83)90307-0. [DOI] [PubMed] [Google Scholar]
  17. Sealy L., Privalsky M. L., Moscovici G., Moscovici C., Bishop J. M. Site-specific mutagenesis of avian erythroblastosis virus: erb-B is required for oncogenicity. Virology. 1983 Oct 15;130(1):155–178. doi: 10.1016/0042-6822(83)90125-3. [DOI] [PubMed] [Google Scholar]
  18. Sergeant A., Saule S., Leprince D., Begue A., Rommens C., Stehelin D. Molecular cloning and characterization of the chicken DNA locus related to the oncogene erbB of avian erythroblastosis virus. EMBO J. 1982;1(2):237–242. doi: 10.1002/j.1460-2075.1982.tb01153.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Taylor J. F., Templeton A. C., Vogel C. L., Ziegler J. L., Kyalwazi S. K. Kaposi's sarcoma in Uganda: a clinico-pathological study. Int J Cancer. 1971 Jul 15;8(1):122–135. doi: 10.1002/ijc.2910080116. [DOI] [PubMed] [Google Scholar]
  20. Vennström B., Bishop J. M. Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell. 1982 Jan;28(1):135–143. doi: 10.1016/0092-8674(82)90383-x. [DOI] [PubMed] [Google Scholar]
  21. Vennström B., Fanshier L., Moscovici C., Bishop J. M. Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells. J Virol. 1980 Nov;36(2):575–585. doi: 10.1128/jvi.36.2.575-585.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Yamamoto T., Hihara H., Nishida T., Kawai S., Toyoshima K. A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas. Cell. 1983 Aug;34(1):225–232. doi: 10.1016/0092-8674(83)90153-8. [DOI] [PubMed] [Google Scholar]
  23. Yamamoto T., Nishida T., Miyajima N., Kawai S., Ooi T., Toyoshima K. The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell. 1983 Nov;35(1):71–78. doi: 10.1016/0092-8674(83)90209-x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES