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. 1985 Jul;55(1):140–146. doi: 10.1128/jvi.55.1.140-146.1985

Nucleotide sequence and structural features of a novel US-a junction present in a defective herpes simplex virus genome.

E S Mocarski, L P Deiss, N Frenkel
PMCID: PMC254908  PMID: 2989551

Abstract

Defective genomes generated during serial propagation of herpes simplex virus type 1 (Justin) consist of tandem reiterations of sequences that are colinear with a portion of the S component of the standard viral genome. We determined the structure of the novel US-a junction, at which the US sequences of one repeat unit join the a sequences of the adjacent repeat unit. Comparison of the nucleotide sequence at this junction with the nucleotide sequence of the corresponding US region of the standard virus genome indicated that the defective genome repeat unit arose by a single recombinational event between an L-S junction a sequence and the US region. The recombinational process might have been mediated by limited sequence homology. The sequences retained within the US-a junction further define the signal for cleavage and packaging of viral DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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