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. 1983 Jan;45(1):104–113. doi: 10.1128/jvi.45.1.104-113.1983

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T.

I S Chen, K C Wilhelmsen, H M Temin
PMCID: PMC256391  PMID: 6296425

Abstract

The cellular homolog of the onc sequences in the avian retrovirus reticuloendotheliosis virus strain T (v-rel) was studied by molecular cloning and nucleic acid hybridization. In contrast to v-rel sequences, which are 1.4 kilobase pairs long, the cellular homolog, c-rel, from line 15B chickens is at least 25 kilobase pairs long, with multiple apparent introns. A 4.0-kilobase polyadenylic acid-containing RNA transcript is the primary species of c-rel RNA present in uninfected chicken cells. Sequences at the 3' end of this c-rel RNA are not present in v-rel.

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Selected References

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