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. 1981 Nov;40(2):526–532. doi: 10.1128/jvi.40.2.526-532.1981

Genomic arrangement of an adenovirus-simian virus 40 hybrid virus, Ad2+ND4del.

H Westphal
PMCID: PMC256655  PMID: 6275101

Abstract

Ad2+ND4del is an adenovirus type 2-simian virus 40 hybrid virus nondefective for growth in human cells. The virus was first observed when stocks of Ad2+ND4, a hybrid isolated from primary monkey kidney cells, were propagated in human cells. This paper describes the DNA sequence at two sites of DNA recombination, the site of the left adenovirus type 2-simian virus 40 junction and the site of a deletion of internal simian virus 40 sequences. Since the deletion was observed when the virus was switched from monkey to human cells, an analysis of gene expression in the region of DNA rearrangement may prove useful for the elucidation of molecular events that accompany virus growth in different hosts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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