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Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 2007 Apr;99(4):328–333.

Smoking, fibrinogen and cancer mortality.

Charles J Everett 1, Brian J Wells 1, Ivar L Frithsen 1, Richelle J Koopman 1
PMCID: PMC2569642  PMID: 17444421

Abstract

Associations of race, smoking history and fibrinogen levels with cancer mortality were investigated prospectively using the ARIC study. Our cohort consisted of 14,320 participants aged 45-64 at baseline. In an adjusted Cox regression, black current heavy smokers (> or = 15 cigarettes per day) demonstrated higher risk of respiratory/intrathoracic organ cancer mortality than nonblack current heavy smokers. Black former heavy smokers were also found to be at an increased risk of respiratory/intrathoracic organ cancer mortality when compared to nonblack former heavy smokers. Elevated fibrinogen levels were associated with an increased risk of respiratory/intrathoracic organ cancer mortality. Compared to fibrinogen < 259 mg/dl, fibrinogen 294-335 mg/dl had an adjusted hazard ratio of 3.68 (95% CI: 1.80-7.55), and fibrinogen > or = 336 mg/dl had an adjusted hazard ratio of 3.78 (95% CI: 1.84-7.75). Fibrinogen was also a predictor of other types of cancer mortality among black participants, but not among nonblack participants. For 10 race/smoking history categories, fibrinogen levels ranged from a mean of 287 mg/dl for nonblack former light smokers to a mean of 338 mg/dl for black current heavy smokers. Smokers had higher fibrinogen levels than nonsmokers, and black smokers had higher fibrinogen levels than nonblack smokers. Smoking carries high risks of cancer mortality for African Americans. A factor that needs to be considered in the overall assessment of risk is fibrinogen level, which has been linked to angiogenesis and metastases of tumors.

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Selected References

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  1. Baecke J. A., Burema J., Frijters J. E. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982 Nov;36(5):936–942. doi: 10.1093/ajcn/36.5.936. [DOI] [PubMed] [Google Scholar]
  2. CLAUSS A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 1957 Apr;17(4):237–246. doi: 10.1159/000205234. [DOI] [PubMed] [Google Scholar]
  3. Caraballo R. S., Giovino G. A., Pechacek T. F., Mowery P. D., Richter P. A., Strauss W. J., Sharp D. J., Eriksen M. P., Pirkle J. L., Maurer K. R. Racial and ethnic differences in serum cotinine levels of cigarette smokers: Third National Health and Nutrition Examination Survey, 1988-1991. JAMA. 1998 Jul 8;280(2):135–139. doi: 10.1001/jama.280.2.135. [DOI] [PubMed] [Google Scholar]
  4. Carpenter C. L., Jarvik M. E., Morgenstern H., McCarthy W. J., London S. J. Mentholated cigarette smoking and lung-cancer risk. Ann Epidemiol. 1999 Feb;9(2):114–120. doi: 10.1016/s1047-2797(98)00042-8. [DOI] [PubMed] [Google Scholar]
  5. Flenaugh Eric L., Henriques-Forsythe Marshaleen N. Lung cancer disparities in African Americans: health versus health care. Clin Chest Med. 2006 Sep;27(3):431-9, vi. doi: 10.1016/j.ccm.2006.04.006. [DOI] [PubMed] [Google Scholar]
  6. Folsom A. R., Arnett D. K., Hutchinson R. G., Liao F., Clegg L. X., Cooper L. S. Physical activity and incidence of coronary heart disease in middle-aged women and men. Med Sci Sports Exerc. 1997 Jul;29(7):901–909. doi: 10.1097/00005768-199707000-00009. [DOI] [PubMed] [Google Scholar]
  7. Folsom A. R., Qamhieh H. T., Flack J. M., Hilner J. E., Liu K., Howard B. V., Tracy R. P. Plasma fibrinogen: levels and correlates in young adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol. 1993 Dec 15;138(12):1023–1036. doi: 10.1093/oxfordjournals.aje.a116821. [DOI] [PubMed] [Google Scholar]
  8. Godtfredsen Nina S., Prescott Eva, Osler Merete. Effect of smoking reduction on lung cancer risk. JAMA. 2005 Sep 28;294(12):1505–1510. doi: 10.1001/jama.294.12.1505. [DOI] [PubMed] [Google Scholar]
  9. Haiman Christopher A., Stram Daniel O., Wilkens Lynne R., Pike Malcolm C., Kolonel Laurence N., Henderson Brian E., Le Marchand Loïc. Ethnic and racial differences in the smoking-related risk of lung cancer. N Engl J Med. 2006 Jan 26;354(4):333–342. doi: 10.1056/NEJMoa033250. [DOI] [PubMed] [Google Scholar]
  10. Olson J. E., Yang P., Schmitz K., Vierkant R. A., Cerhan J. R., Sellers T. A. Differential association of body mass index and fat distribution with three major histologic types of lung cancer: evidence from a cohort of older women. Am J Epidemiol. 2002 Oct 1;156(7):606–615. doi: 10.1093/aje/kwf084. [DOI] [PubMed] [Google Scholar]
  11. Palumbo J. S., Kombrinck K. W., Drew A. F., Grimes T. S., Kiser J. H., Degen J. L., Bugge T. H. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood. 2000 Nov 15;96(10):3302–3309. [PubMed] [Google Scholar]
  12. Palumbo Joseph S., Potter Jill M., Kaplan Lisa S., Talmage Kathryn, Jackson David G., Degen Jay L. Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res. 2002 Dec 1;62(23):6966–6972. [PubMed] [Google Scholar]
  13. Palumbo Joseph S., Talmage Kathryn E., Massari Jessica V., La Jeunesse Christine M., Flick Matthew J., Kombrinck Keith W., Jirousková Markéta, Degen Jay L. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood. 2004 Sep 14;105(1):178–185. doi: 10.1182/blood-2004-06-2272. [DOI] [PubMed] [Google Scholar]
  14. Papp A. C., Hatzakis H., Bracey A., Wu K. K. ARIC hemostasis study--I. Development of a blood collection and processing system suitable for multicenter hemostatic studies. Thromb Haemost. 1989 Feb 28;61(1):15–19. [PubMed] [Google Scholar]
  15. Schmitz K. H., Arnett D. K., Bank A., Liao D., Evans G. W., Evenson K. R., Stevens J., Sorlie P., Folsom A. R. Arterial distensibility and physical activity in the ARIC study. Med Sci Sports Exerc. 2001 Dec;33(12):2065–2071. doi: 10.1097/00005768-200112000-00014. [DOI] [PubMed] [Google Scholar]
  16. Singh Gopal K., Miller Barry A., Hankey Benjamin F. Changing area socioeconomic patterns in U.S. cancer mortality, 1950-1998: Part II--Lung and colorectal cancers. J Natl Cancer Inst. 2002 Jun 19;94(12):916–925. doi: 10.1093/jnci/94.12.916. [DOI] [PubMed] [Google Scholar]
  17. Singh Gopal K., Miller Barry A., Hankey Benjamin F., Feuer Eric J., Pickle Linda W. Changing area socioeconomic patterns in U.S. cancer mortality, 1950-1998: Part I--All cancers among men. J Natl Cancer Inst. 2002 Jun 19;94(12):904–915. doi: 10.1093/jnci/94.12.904. [DOI] [PubMed] [Google Scholar]
  18. Sinha Shubhada, Luben Robert N., Welch Ailsa, Bingham Sheila, Wareham Nicholas J., Day Nicholas E., Khaw Kay-Tee. Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population. Eur J Cardiovasc Prev Rehabil. 2005 Apr;12(2):144–150. doi: 10.1097/01.hjr.0000140719.09768.e2. [DOI] [PubMed] [Google Scholar]
  19. Staton Carolyn A., Brown Nicola J., Lewis Claire E. The role of fibrinogen and related fragments in tumour angiogenesis and metastasis. Expert Opin Biol Ther. 2003 Oct;3(7):1105–1120. doi: 10.1517/14712598.3.7.1105. [DOI] [PubMed] [Google Scholar]
  20. Stellman Steven D., Chen Yu, Muscat Joshua E., Djordjevic Mirjana V., Richie John P., Jr, Lazarus Philip, Thompson Seth, Altorki Nasser, Berwick Marianne, Citron Marc L. Lung cancer risk in white and black Americans. Ann Epidemiol. 2003 Apr;13(4):294–302. doi: 10.1016/s1047-2797(02)00420-9. [DOI] [PubMed] [Google Scholar]
  21. Tardon Adonina, Lee Won Jin, Delgado-Rodriguez Miguel, Dosemeci Mustafa, Albanes Demetrius, Hoover Robert, Blair Aaron. Leisure-time physical activity and lung cancer: a meta-analysis. Cancer Causes Control. 2005 May;16(4):389–397. doi: 10.1007/s10552-004-5026-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Wojtukiewicz Marek Z., Sierko Ewa, Rak Janusz. Contribution of the hemostatic system to angiogenesis in cancer. Semin Thromb Hemost. 2004 Feb;30(1):5–20. doi: 10.1055/s-2004-822967. [DOI] [PubMed] [Google Scholar]

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