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. 1990 Dec;82(12):833–836.

Cerebral calcification and learning disabilities following cranial irradiation for medulloblastoma.

O Abayomi 1, M S Chun 1, K Kelly 1
PMCID: PMC2571524  PMID: 2280428

Abstract

Six children who received craniospinal irradiation for medulloblastoma when they were under 10 years of age developed learning disabilities. Four exhibited associated temporal lobe calcification on computerized tomography of the brain. The pathogenetic mechanisms of postirradiation cerebral calcification and learning disabilities in these children are discussed. We present the hypothesis that irradiation-induced vasculopathy results in hypoxia, most pronounced in the hippocampus. Hippocampal damage can manifest radiologically as calcifications and clinically as memory and learning disabilities.

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Selected References

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  1. Brant-Zawadzki M., Anderson M., DeArmond S. J., Conley F. K., Jahnke R. W. Radiation-induced large intracranial vessel occlusive vasculopathy. AJR Am J Roentgenol. 1980 Jan;134(1):51–55. doi: 10.2214/ajr.134.1.51. [DOI] [PubMed] [Google Scholar]
  2. Brouwers P., Riccardi R., Fedio P., Poplack D. G. Long-term neuropsychologic sequelae of childhood leukemia: correlation with CT brain scan abnormalities. J Pediatr. 1985 May;106(5):723–728. doi: 10.1016/s0022-3476(85)80343-7. [DOI] [PubMed] [Google Scholar]
  3. Chin H. W., Maruyama Y. Age at treatment and long-term performance results in medulloblastoma. Cancer. 1984 May 1;53(9):1952–1958. doi: 10.1002/1097-0142(19840501)53:9<1952::aid-cncr2820530925>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  4. Evans J. H. Transient loss of memory, an organic mental syndrome. Brain. 1966 Sep;89(3):539–548. doi: 10.1093/brain/89.3.539. [DOI] [PubMed] [Google Scholar]
  5. Godfrey S. Exercise-induced asthma. Arch Dis Child. 1983 Jan;58(1):1–2. doi: 10.1136/adc.58.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harwood-Nash D. C., Reilly B. J. Calcification of the basal ganglia following radiation therapy. Am J Roentgenol Radium Ther Nucl Med. 1970 Feb;108(2):392–395. doi: 10.2214/ajr.108.2.392. [DOI] [PubMed] [Google Scholar]
  7. Hirsch J. F., Renier D., Czernichow P., Benveniste L., Pierre-Kahn A. Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien) 1979;48(1-2):1–15. doi: 10.1007/BF01406016. [DOI] [PubMed] [Google Scholar]
  8. Iwaski Y., Kinoshita M., Takamiya K. Rapid development of basal ganglia calcification caused by anoxia. J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):449–450. doi: 10.1136/jnnp.51.3.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kun L. E., Mulhern R. K., Crisco J. J. Quality of life in children treated for brain tumors. Intellectual, emotional, and academic function. J Neurosurg. 1983 Jan;58(1):1–6. doi: 10.3171/jns.1983.58.1.0001. [DOI] [PubMed] [Google Scholar]
  10. Margerison J. H., Corsellis J. A. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes. Brain. 1966 Sep;89(3):499–530. doi: 10.1093/brain/89.3.499. [DOI] [PubMed] [Google Scholar]
  11. McIntosh S., Fischer D. B., Rothman S. G., Rosenfield N., Lobel J. S., O'Brien R. Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy. J Pediatr. 1977 Dec;91(6):909–913. doi: 10.1016/s0022-3476(77)80888-3. [DOI] [PubMed] [Google Scholar]
  12. Meadows A. T., Gordon J., Massari D. J., Littman P., Fergusson J., Moss K. Declines in IQ scores and cognitive dysfunctions in children with acute lymphocytic leukaemia treated with cranial irradiation. Lancet. 1981 Nov 7;2(8254):1015–1018. doi: 10.1016/s0140-6736(81)91216-2. [DOI] [PubMed] [Google Scholar]
  13. Painter M. J., Chutorian A. M., Hilal S. K. Cerebrovasculopathy following irradiation in childhood. Neurology. 1975 Feb;25(2):189–194. doi: 10.1212/wnl.25.2.189. [DOI] [PubMed] [Google Scholar]
  14. Price R. A., Birdwell D. A. The central nervous system in childhood leukemia. III. Mineralizing microangiopathy and dystrophic calcification. Cancer. 1978 Aug;42(2):717–728. doi: 10.1002/1097-0142(197808)42:2<717::aid-cncr2820420244>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  15. Riccardi R., Brouwers P., Di Chiro G., Poplack D. G. Abnormal computed tomography brain scans in children with acute lymphoblastic leukemia: serial long-term follow-up. J Clin Oncol. 1985 Jan;3(1):12–18. doi: 10.1200/JCO.1985.3.1.12. [DOI] [PubMed] [Google Scholar]
  16. SCOVILLE W. B., MILNER B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11–21. doi: 10.1136/jnnp.20.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Silverman C. L., Palkes H., Talent B., Kovnar E., Clouse J. W., Thomas P. R. Late effects of radiotherapy on patients with cerebellar medulloblastoma. Cancer. 1984 Sep 1;54(5):825–829. doi: 10.1002/1097-0142(19840901)54:5<825::aid-cncr2820540511>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  18. Towbin A. Mental retardation due to germinal matrix infarction. Science. 1969 Apr 11;164(3876):156–161. doi: 10.1126/science.164.3876.156. [DOI] [PubMed] [Google Scholar]
  19. Twaddle V., Britton P. G., Craft A. C., Noble T. C., Kernahan J. Intellectual function after treatment for leukaemia or solid tumours. Arch Dis Child. 1983 Dec;58(12):949–952. doi: 10.1136/adc.58.12.949. [DOI] [PMC free article] [PubMed] [Google Scholar]

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