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. 1992 Sep;60(9):3947–3951. doi: 10.1128/iai.60.9.3947-3951.1992

A conjugated synthetic peptide corresponding to the C-terminal region of Clostridium perfringens type A enterotoxin elicits an enterotoxin-neutralizing antibody response in mice.

T A Mietzner 1, J F Kokai-Kun 1, P C Hanna 1, B A McClane 1
PMCID: PMC257418  PMID: 1500207

Abstract

A synthetic peptide homolog corresponding to the C-terminal 30 amino acids of Clostridium perfringens type A enterotoxin (CPE) was conjugated to a thyroglobulin carrier and used to immunize mice. Conjugate-immunized mice produced antibodies which neutralized native CPE cytotoxicity, at least in part, by blocking enterotoxin binding. This peptide may be useful for the development of a vaccine to protect against CPE-mediated disease.

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Selected References

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