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. 1992 Oct;60(10):4418–4421. doi: 10.1128/iai.60.10.4418-4421.1992

Depletion of tryptophan is not involved in expression of tryptophanyl-tRNA synthetase mediated by interferon.

T Flohr 1, F C Bange 1, A von Euch 1, M Kiekenbeck 1, E C Böttger 1
PMCID: PMC257482  PMID: 1398953

Abstract

Gamma interferon (IFN-gamma) affects tryptophan metabolism by mediating the expression of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase. In the present study, we investigated the role of indoleamine 2,3-dioxygenase-mediated tryptophan depletion in the induction of tryptophanyl-tRNA synthetase by IFN-gamma. The addition of excess tryptophan to the culture medium did not affect the induction of tryptophanyl-tRNA synthetase by IFN-gamma, indicating that tryptophan degradation is not directly involved in the IFN-gamma-mediated expression of tryptophanyl-tRNA synthetase.

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Selected References

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