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. 2007 May;99(5):509–516.

Association between past urinary tract infections and current symptoms suggestive of chronic prostatitis/chronic pelvic pain syndrome.

Nicholas A Daniels 1, Carol L Link 1, Michael J Barry 1, John B McKinlay 1
PMCID: PMC2576075  PMID: 17534008

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a major cause of illness, and its association with history of past urinary tract infections is unclear. We surveyed a racially, ethnically and socioeconomically diverse, community-based sample of adults aged 30-79 years in Boston, MA. This report gives estimates from the 2,301 men in the BACH survey: 700 black, 766 Hispanic and 835 white. Symptoms of chronic prostatitis--any perineal and/or ejaculatory pain and a pain score of > or =4--were derived from the NIH Chronic Prostatitis Symptom Index and were used to identify men with symptoms suggesting CP/CPPS. The overall prevalence of symptoms suggestive of CP/CPPS is 6.3%. The number of urinary tract infections, particularly >3, was associated with symptoms suggestive of CP/CPPS (P < 0.01). There is a strong association between current symptoms of CP/CPPS and a history of urinary tract infections, particularly of multiple infections. The causality between chronic UTIs and CP/CPPS needs to be clarified by further study.

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Selected References

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  1. Barnes R. C., Daifuku R., Roddy R. E., Stamm W. E. Urinary-tract infection in sexually active homosexual men. Lancet. 1986 Jan 25;1(8474):171–173. doi: 10.1016/s0140-6736(86)90650-1. [DOI] [PubMed] [Google Scholar]
  2. Berger R. E., Krieger J. N., Kessler D., Ireton R. C., Close C., Holmes K. K., Roberts P. L. Case-control study of men with suspected chronic idiopathic prostatitis. J Urol. 1989 Feb;141(2):328–331. doi: 10.1016/s0022-5347(17)40757-9. [DOI] [PubMed] [Google Scholar]
  3. Collins M. M., Stafford R. S., O'Leary M. P., Barry M. J. How common is prostatitis? A national survey of physician visits. J Urol. 1998 Apr;159(4):1224–1228. [PubMed] [Google Scholar]
  4. Collins Mary McNaughton, Meigs James B., Barry Michael J., Walker Corkery Elizabeth, Giovannucci Edward, Kawachi Ichiro. Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. J Urol. 2002 Mar;167(3):1363–1366. [PubMed] [Google Scholar]
  5. Feldman H. A., McKinlay S. M., Niknian M. Batch sampling to improve power in a community trial. Experience from the Pawtucket Heart Health Program. Eval Rev. 1996 Jun;20(3):244–274. doi: 10.1177/0193841X9602000302. [DOI] [PubMed] [Google Scholar]
  6. Foxman Betsy. Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Dis Mon. 2003 Feb;49(2):53–70. doi: 10.1067/mda.2003.7. [DOI] [PubMed] [Google Scholar]
  7. Green L. W. Manual for scoring socioeconomic status for research on health behavior. Public Health Rep. 1970 Sep;85(9):815–827. [PMC free article] [PubMed] [Google Scholar]
  8. Griebling Tomas L. Urologic diseases in america project: trends in resource use for urinary tract infections in men. J Urol. 2005 Apr;173(4):1288–1294. doi: 10.1097/01.ju.0000155595.98120.8e. [DOI] [PubMed] [Google Scholar]
  9. Krieger John N., Riley Donald E., Cheah Phaik Yeong, Liong Men Long, Yuen Kah Hay. Epidemiology of prostatitis: new evidence for a world-wide problem. World J Urol. 2003 Apr 24;21(2):70–74. doi: 10.1007/s00345-003-0329-0. [DOI] [PubMed] [Google Scholar]
  10. Lipsky B. A. Prostatitis and urinary tract infection in men: what's new; what's true? Am J Med. 1999 Mar;106(3):327–334. doi: 10.1016/s0002-9343(99)00017-0. [DOI] [PubMed] [Google Scholar]
  11. Litwin M. S., McNaughton-Collins M., Fowler F. J., Jr, Nickel J. C., Calhoun E. A., Pontari M. A., Alexander R. B., Farrar J. T., O'Leary M. P. The National Institutes of Health chronic prostatitis symptom index: development and validation of a new outcome measure. Chronic Prostatitis Collaborative Research Network. J Urol. 1999 Aug;162(2):369–375. doi: 10.1016/s0022-5347(05)68562-x. [DOI] [PubMed] [Google Scholar]
  12. Nickel J. C., Downey J., Hunter D., Clark J. Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index. J Urol. 2001 Mar;165(3):842–845. [PubMed] [Google Scholar]
  13. Nickel J. C., Nyberg L. M., Hennenfent M. Research guidelines for chronic prostatitis: consensus report from the first National Institutes of Health International Prostatitis Collaborative Network. Urology. 1999 Aug;54(2):229–233. doi: 10.1016/s0090-4295(99)00205-8. [DOI] [PubMed] [Google Scholar]
  14. Nicolle L. E., Henderson E., Bjornson J., McIntyre M., Harding G. K., MacDonell J. A. The association of bacteriuria with resident characteristics and survival in elderly institutionalized men. Ann Intern Med. 1987 May;106(5):682–686. doi: 10.7326/0003-4819-106-5-682. [DOI] [PubMed] [Google Scholar]
  15. Palapattu Ganesh S., Sutcliffe Siobhan, Bastian Patrick J., Platz Elizabeth A., De Marzo Angelo M., Isaacs William B., Nelson William G. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis. 2004 Oct 21;26(7):1170–1181. doi: 10.1093/carcin/bgh317. [DOI] [PubMed] [Google Scholar]
  16. Platz Elizabeth A., De Marzo Angelo M. Epidemiology of inflammation and prostate cancer. J Urol. 2004 Feb;171(2 Pt 2):S36–S40. doi: 10.1097/01.ju.0000108131.43160.77. [DOI] [PubMed] [Google Scholar]
  17. Pontari Michel A., McNaughton-Collins Mary, O'leary Michael P., Calhoun Elizabeth A., Jang Thomas, Kusek John W., Landis J. Richard, Knauss Jill, Litwin Mark S., CPCRN Study Group A case-control study of risk factors in men with chronic pelvic pain syndrome. BJU Int. 2005 Sep;96(4):559–565. doi: 10.1111/j.1464-410X.2005.05684.x. [DOI] [PubMed] [Google Scholar]
  18. Roberts R. O., Lieber M. M., Rhodes T., Girman C. J., Bostwick D. G., Jacobsen S. J. Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urology. 1998 Apr;51(4):578–584. doi: 10.1016/s0090-4295(98)00034-x. [DOI] [PubMed] [Google Scholar]
  19. Roberts R. O., Lieber M. M., Rhodes T., Girman C. J., Bostwick D. G., Jacobsen S. J. Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urology. 1998 Apr;51(4):578–584. doi: 10.1016/s0090-4295(98)00034-x. [DOI] [PubMed] [Google Scholar]
  20. Roberts Rosebud O., Jacobson Debra J., Girman Cynthia J., Rhodes Thomas, Lieber Michael M., Jacobsen Steven J. Prevalence of prostatitis-like symptoms in a community based cohort of older men. J Urol. 2002 Dec;168(6):2467–2471. doi: 10.1016/S0022-5347(05)64170-5. [DOI] [PubMed] [Google Scholar]
  21. Rothman Ivan, Stanford Janet L., Kuniyuki Alan, Berger Richard E. Self-report of prostatitis and its risk factors in a random sample of middle-aged men. Urology. 2004 Nov;64(5):876–880. doi: 10.1016/j.urology.2004.06.071. [DOI] [PubMed] [Google Scholar]
  22. Spach D. H., Stapleton A. E., Stamm W. E. Lack of circumcision increases the risk of urinary tract infection in young men. JAMA. 1992 Feb 5;267(5):679–681. [PubMed] [Google Scholar]
  23. Turner Judith A., Ciol Marcia A., Von Korff Michael, Berger Richard. Validity and responsiveness of the national institutes of health chronic prostatitis symptom index. J Urol. 2003 Feb;169(2):580–583. doi: 10.1097/01.ju.0000047620.95034.a5. [DOI] [PubMed] [Google Scholar]
  24. Turner Judith A., Hauge Stephanie, Von Korff Michael, Saunders Kathleen, Lowe Marc, Berger Richard. Primary care and urology patients with the male pelvic pain syndrome: symptoms and quality of life. J Urol. 2002 Apr;167(4):1768–1773. [PubMed] [Google Scholar]
  25. Ulleryd Peter. Febrile urinary tract infection in men. Int J Antimicrob Agents. 2003 Oct;22 (Suppl 2):89–93. doi: 10.1016/s0924-8579(03)00228-0. [DOI] [PubMed] [Google Scholar]
  26. Wagenlehner F. M. E., Naber K. G. Fluoroquinolone Antimicrobial Agents in the Treatment of Prostatitis and Recurrent Urinary Tract Infections in Men. Curr Infect Dis Rep. 2005 Jan;7(1):9–16. doi: 10.1007/s11908-005-0018-9. [DOI] [PubMed] [Google Scholar]
  27. Ware J., Jr, Kosinski M., Keller S. D. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996 Mar;34(3):220–233. doi: 10.1097/00005650-199603000-00003. [DOI] [PubMed] [Google Scholar]
  28. Weidner Wolfgang. Treating chronic prostatitis: antibiotics no, alpha-blockers maybe. Ann Intern Med. 2004 Oct 19;141(8):639–640. doi: 10.7326/0003-4819-141-8-200410190-00012. [DOI] [PubMed] [Google Scholar]
  29. Winberg J., Bollgren I., Gothefors L., Herthelius M., Tullus K. The prepuce: a mistake of nature? Lancet. 1989 Mar 18;1(8638):598–599. doi: 10.1016/s0140-6736(89)91619-x. [DOI] [PubMed] [Google Scholar]

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