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. 1991 Apr;59(4):1387–1393. doi: 10.1128/iai.59.4.1387-1393.1991

Recombinant derivatives of Pasteurella multocida toxin: candidates for a vaccine against progressive atrophic rhinitis.

S K Petersen 1, N T Foged 1, A Bording 1, J P Nielsen 1, H K Riemann 1, P L Frandsen 1
PMCID: PMC257854  PMID: 1706320

Abstract

Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a lack of toxic activity. One such component was shown to induce efficient protection of vaccinated female mice and their offspring against challenge with purified P. multocida toxin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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