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. 1992 Dec;60(12):5294–5297. doi: 10.1128/iai.60.12.5294-5297.1992

Frequency of antigen-specific B cells during experimental ocular Chlamydia trachomatis infection.

S Pal 1, H R Taylor 1, R B Huneke 1, R A Prendergast 1, J A Whittum-Hudson 1
PMCID: PMC258309  PMID: 1452363

Abstract

Chlamydia-specific antibody-secreting cells have been identified in conjunctiva and draining cervical lymph nodes by an ELISPOT assay in a cynomolgus monkey model of trachoma. These local sites contained numbers of chlamydia-specific B cells that were higher than those in distant inguinal lymph nodes and peripheral blood. The numbers of chlamydia-specific immunoglobulin G-secreting B cells observed were 5 to 57 per 10(6) cells in conjunctiva and 24 to 996 per 10(6) cells in cervical lymph nodes during conjunctival infection or after challenge of immune monkeys with the chlamydial 57-kDa heat shock protein (hsp60). These studies demonstrate a large chlamydia-specific B-cell component in the conjunctiva during ocular chlamydial infection. These results are similar to our findings for chlamydia-specific T-cell responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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