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. 1991 Mar;59(3):1206–1209. doi: 10.1128/iai.59.3.1206-1209.1991

Specific immune response in the human respiratory tract following oral immunization with live typhoid vaccine.

B D Forrest 1, J T LaBrooy 1, P Robinson 1, C E Dearlove 1, D J Shearman 1
PMCID: PMC258392  PMID: 1997425

Abstract

Specific antibody responses in the lower respiratory tract of human subjects to orally administered Salmonella typhi Ty21a are reported. These responses, predominantly of the immunoglobulin G class, were determined to be a transudate from serum. These results were supported by the similarity in responses to parenteral administration of heat-killed typhoid vaccine. Specific immunoglobulin A antibody was a poor contributor to the respiratory antibody response to either vaccine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Forrest B. D., LaBrooy J. T., Attridge S. R., Boehm G., Beyer L., Morona R., Shearman D. J., Rowley D. Immunogenicity of a candidate live oral typhoid/cholera hybrid vaccine in humans. J Infect Dis. 1989 Jan;159(1):145–146. doi: 10.1093/infdis/159.1.145. [DOI] [PubMed] [Google Scholar]
  2. Forrest B. D., Shearman D. J., LaBrooy J. T. Specific immune response in humans following rectal delivery of live typhoid vaccine. Vaccine. 1990 Jun;8(3):209–212. doi: 10.1016/0264-410x(90)90047-p. [DOI] [PubMed] [Google Scholar]
  3. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  4. Mestecky J., McGhee J. R., Arnold R. R., Michalek S. M., Prince S. J., Babb J. L. Selective induction of an immune response in human external secretions by ingestion of bacterial antigen. J Clin Invest. 1978 Mar;61(3):731–737. doi: 10.1172/JCI108986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mestecky J. The common mucosal immune system and current strategies for induction of immune responses in external secretions. J Clin Immunol. 1987 Jul;7(4):265–276. doi: 10.1007/BF00915547. [DOI] [PubMed] [Google Scholar]
  6. Ogra P. L., Karzon D. T. Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine. J Immunol. 1969 Jun;102(6):1423–1430. [PubMed] [Google Scholar]
  7. Reynolds H. Y. Bronchoalveolar lavage. Am Rev Respir Dis. 1987 Jan;135(1):250–263. doi: 10.1164/arrd.1987.135.1.250. [DOI] [PubMed] [Google Scholar]
  8. Tacket C. O., Forrest B., Morona R., Attridge S. R., LaBrooy J., Tall B. D., Reymann M., Rowley D., Levine M. M. Safety, immunogenicity, and efficacy against cholera challenge in humans of a typhoid-cholera hybrid vaccine derived from Salmonella typhi Ty21a. Infect Immun. 1990 Jun;58(6):1620–1627. doi: 10.1128/iai.58.6.1620-1627.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wagner D. K., Clements M. L., Reimer C. B., Snyder M., Nelson D. L., Murphy B. R. Analysis of immunoglobulin G antibody responses after administration of live and inactivated influenza A vaccine indicates that nasal wash immunoglobulin G is a transudate from serum. J Clin Microbiol. 1987 Mar;25(3):559–562. doi: 10.1128/jcm.25.3.559-562.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Weisz-Carrington P., Grimes S. R., Jr, Lamm M. E. Gut-associated lymphoid tissue as source of an IgA immune response in respiratory tissues after oral immunization and intrabronchial challenge. Cell Immunol. 1987 Apr 15;106(1):132–138. doi: 10.1016/0008-8749(87)90156-0. [DOI] [PubMed] [Google Scholar]
  11. Weisz-Carrington P., Roux M. E., McWilliams M., PHILLIPS-Quagliata J. M., Lamm M. E. Organ and isotype distribution of plasma cells producing specific antibody after oral immunization: evidence for a generalized secretory immune system. J Immunol. 1979 Oct;123(4):1705–1708. [PubMed] [Google Scholar]

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