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. 2001 Jul-Aug;93(7-8):251–255.

Nonfunctional parathyroid carcinoma.

G A Giessler 1, D J Beech 1
PMCID: PMC2594040  PMID: 11491274

Abstract

Parathyroid carcinoma is a rare entity accounting for 0.5% to 5% of parathyroid neoplasia. Most of these malignancies present as functional hormone-producing masses with elevated serum levels of parathormone and calcium. These tumors may also be nonfunctional. Clinical detection of nonfunctioning parathyroid malignancies preoperatively is primarily based on symptoms of an expanding neck mass. This ominous complaint is typically accompanied with an advanced stage of the disease at initial diagnosis. Because there is a paucity of data in the literature regarding nonfunctioning parathyroid carcinoma, prognosis can not be readily assessed. In both functional and nonfunctional parathyroid carcinoma, early surgery has proven to be the only curative treatment approach whereas both chemotherapy and radiation therapy fail to produce systemic or regional benefit when used alone. Hence, parathyroid cancer should be considered in every patient evaluated for a neck mass regardless of the blood calcium and blood parathormone level.

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Selected References

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  1. Aldinger K. A., Hickey R. C., Ibanez M. L., Samaan N. A. Parathyroid carcinoma: a clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer. Cancer. 1982 Jan 15;49(2):388–397. doi: 10.1002/1097-0142(19820115)49:2<388::aid-cncr2820490230>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  2. Anderson B. J., Samaan N. A., Vassilopoulou-Sellin R., Ordonez N. G., Hickey R. C. Parathyroid carcinoma: features and difficulties in diagnosis and management. Surgery. 1983 Dec;94(6):906–915. [PubMed] [Google Scholar]
  3. Bondeson L., Sandelin K., Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol. 1993 Aug;17(8):820–829. doi: 10.1097/00000478-199308000-00007. [DOI] [PubMed] [Google Scholar]
  4. Bondeson L., Sandelin K., Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol. 1993 Aug;17(8):820–829. doi: 10.1097/00000478-199308000-00007. [DOI] [PubMed] [Google Scholar]
  5. Bukowski R. M., Sheeler L., Cunningham J., Esselstyn C. Successful combination chemotherapy for metastatic parathyroid carcinoma. Arch Intern Med. 1984 Feb;144(2):399–400. [PubMed] [Google Scholar]
  6. Chow E., Tsang R. W., Brierley J. D., Filice S. Parathyroid carcinoma--the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys. 1998 Jun 1;41(3):569–572. doi: 10.1016/s0360-3016(98)00098-4. [DOI] [PubMed] [Google Scholar]
  7. Collins F. D., Warren M. C., Palmer F. J., Rankin D. R. Nonfunctioning parathyroid carcinoma: a case history. J Surg Oncol. 1986 Jan;31(1):60–61. doi: 10.1002/jso.2930310114. [DOI] [PubMed] [Google Scholar]
  8. Cordeiro A. C., Montenegro F. L., Kulcsar M. A., Dellanegra L. A., Tavares M. R., Michaluart P., Jr, Ferraz A. R. Parathyroid carcinoma. Am J Surg. 1998 Jan;175(1):52–55. doi: 10.1016/s0002-9610(97)00228-6. [DOI] [PubMed] [Google Scholar]
  9. Fujimoto Y., Obara T. How to recognize and treat parathyroid carcinoma. Surg Clin North Am. 1987 Apr;67(2):343–357. doi: 10.1016/s0039-6109(16)44188-5. [DOI] [PubMed] [Google Scholar]
  10. Holmes E. C., Morton D. L., Ketcham A. S. Parathyroid carcinoma: a collective review. Ann Surg. 1969 Apr;169(4):631–640. doi: 10.1097/00000658-196904000-00022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Klink B. K., Karulf R. E., Maimon W. N., Peoples J. B. Nonfunctioning parathyroid carcinoma. Am Surg. 1991 Jul;57(7):463–467. [PubMed] [Google Scholar]
  12. McCance D. R., Kenny B. D., Sloan J. M., Russell C. F., Hadden D. R. Parathyroid carcinoma: a review. J R Soc Med. 1987 Aug;80(8):505–509. doi: 10.1177/014107688708000816. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. McKeown P. P., McGarity W. C., Sewell C. W. Carcinoma of the parathyroid gland: is it overdiagnosed? A report of three cases. Am J Surg. 1984 Feb;147(2):292–298. doi: 10.1016/0002-9610(84)90110-7. [DOI] [PubMed] [Google Scholar]
  14. Merlano M., Conte P., Scarsi P., Tatarek R., Barbieri A., Santelli A., Scarpati D., De Angelis P. Non-functioning parathyroid carcinoma: a case report. Tumori. 1985 Apr 30;71(2):193–196. doi: 10.1177/030089168507100216. [DOI] [PubMed] [Google Scholar]
  15. Murphy M. N., Glennon P. G., Diocee M. S., Wick M. R., Cavers D. J. Nonsecretory parathyroid carcinoma of the mediastinum. Light microscopic, immunocytochemical, and ultrastructural features of a case, and review of the literature. Cancer. 1986 Dec 1;58(11):2468–2476. doi: 10.1002/1097-0142(19861201)58:11<2468::aid-cncr2820581120>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  16. Ordoñez N. G., Ibañez M. L., Samaan N. A., Hickey R. C. Immunoperoxidase study of uncommon parathyroid tumors. Report of two cases of nonfunctioning parathyroid carcinoma and one intrathyroid parathyroid tumor-producing amyloid. Am J Surg Pathol. 1983 Sep;7(6):535–542. doi: 10.1097/00000478-198309000-00004. [DOI] [PubMed] [Google Scholar]
  17. Park S. T., Condemi G., Shakir K. M., Larson D., Miller D., Ghosh B. C. Parathyroid carcinoma: report of three cases and review of the literature. Mil Med. 1998 Apr;163(4):246–249. [PubMed] [Google Scholar]
  18. Schantz A., Castleman B. Parathyroid carcinoma. A study of 70 cases. Cancer. 1973 Mar;31(3):600–605. doi: 10.1002/1097-0142(197303)31:3<600::aid-cncr2820310316>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  19. Shane E. Parathyroid carcinoma. Curr Ther Endocrinol Metab. 1997;6:565–568. [PubMed] [Google Scholar]
  20. Shapiro D. H., Jurado R. Recurrent parathyroid carcinoma: value of aggressive surgical approach. J Fla Med Assoc. 1984 Dec;71(12):937–938. [PubMed] [Google Scholar]
  21. Shortell C. K., Andrus C. H., Phillips C. E., Jr, Schwartz S. I. Carcinoma of the parathyroid gland: a 30-year experience. Surgery. 1991 Oct;110(4):704–708. [PubMed] [Google Scholar]
  22. Skulchan V., Tepmongkol P., Dharamadach A., Padmanidhi P. Malignant tumour of the parathyroid gland : report of case. J Med Assoc Thai. 1983 Dec;66(12):812–817. [PubMed] [Google Scholar]
  23. Trigonis C., Cedermark B., Willems J., Hamberger B., Granberg P. O. Parathyroid carcinoma--problems in diagnosis and treatment. Clin Oncol. 1984 Mar;10(1):11–19. [PubMed] [Google Scholar]
  24. Vainas I. G., Tsilikas C., Grecu A., Pasaitu K., Stergiou I., Kortsaris A. H. Metastatic parathyroid carcinoma (mPCa): natural history and treatment of a case. J Exp Clin Cancer Res. 1997 Dec;16(4):429–432. [PubMed] [Google Scholar]
  25. Vázquez-Quintana E. Parathyroid carcinoma: diagnosis and management. Am Surg. 1997 Nov;63(11):954–957. [PubMed] [Google Scholar]
  26. Wahl R. A., König M., Schmidt-Gayk H., Röher H. D. Hormonaktives versus hormoninaktives Epithel-körperchenkarzinom. Wien Med Wochenschr. 1988 Sep 30;138(18):461–464. [PubMed] [Google Scholar]
  27. Wang C. A., Gaz R. D. Natural history of parathyroid carcinoma. Diagnosis, treatment, and results. Am J Surg. 1985 Apr;149(4):522–527. doi: 10.1016/s0002-9610(85)80050-7. [DOI] [PubMed] [Google Scholar]
  28. Wynne A. G., van Heerden J., Carney J. A., Fitzpatrick L. A. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore) 1992 Jul;71(4):197–205. [PubMed] [Google Scholar]
  29. Yamashita H., Noguchi S., Nakayama I., Togon H., Moriuchi A., Yokoyama S., Mochizuki Y., Noguchi A. Light and electron microscopic study of nonfunctioning parathyroid carcinoma. Report of a case with a review of the literature. Acta Pathol Jpn. 1984 Jan;34(1):123–132. doi: 10.1111/j.1440-1827.1984.tb02190.x. [DOI] [PubMed] [Google Scholar]
  30. van Heerden J. A., Weiland L. H., ReMine W. H., Walls J. T., Purnell D. C. Cancer of the parathyroid glands. Arch Surg. 1979 Apr;114(4):475–480. doi: 10.1001/archsurg.1979.01370280129019. [DOI] [PubMed] [Google Scholar]

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