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. 2003 Jan;95(1):55–63.

Radiation medicine innovations for the new millenium.

Dwight E Heron 1, Karen D Godette 1, Ray A Wynn 1, V Elayne Arterbery 1, Oscar A Streeter 1, Mack Roach 3rd 1, Joseph R Simpson 1, Melissa Blough 1, Charles R Thomas Jr 1
PMCID: PMC2594374  PMID: 12656450

Abstract

PURPOSE OF THE STUDY: To review technological advances in the field of radiation oncology in the management of benign and malignant diseases. BASIC PROCEDURES: We reviewed major advances in the field of radiation oncology in the past decade with special emphasis on reduction of treatment related toxicities, and technological improvements in planning and delivery of radiation. Modalities reviewed include computerized three-dimensional conformal treatment planning, stereotactic radiosurgery, intensity-modulated radiation therapy, ultrasound-guided transperineal permanent brachytherapy of the prostate, and high-dose rate brachytherapy. MAIN FINDINGS: There have been major technological advances as evidenced by a decrease in treatment-related toxicities and better target definition resulting in higher local control rates. PRINCIPAL CONCLUSIONS: Significant improvements in technique and equipment have firmly positioned radiotherapy as major artillery in the fight against both benign and malignant diseases.

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Selected References

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  1. Auchter R. M., Lamond J. P., Alexander E., Buatti J. M., Chappell R., Friedman W. A., Kinsella T. J., Levin A. B., Noyes W. R., Schultz C. J. A multiinstitutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis. Int J Radiat Oncol Biol Phys. 1996 Apr 1;35(1):27–35. doi: 10.1016/s0360-3016(96)85008-5. [DOI] [PubMed] [Google Scholar]
  2. Bittl J. A. Advances in coronary angioplasty. N Engl J Med. 1996 Oct 24;335(17):1290–1302. doi: 10.1056/NEJM199610243351707. [DOI] [PubMed] [Google Scholar]
  3. Chang J. H., Chang J. W., Park Y. G., Chung S. S. Factors related to complete occlusion of arteriovenous malformations after gamma knife radiosurgery. J Neurosurg. 2000 Dec;93 (Suppl 3):96–101. doi: 10.3171/sup.2000.93.supplement3.0096. [DOI] [PubMed] [Google Scholar]
  4. Chao K. S., Deasy J. O., Markman J., Haynie J., Perez C. A., Purdy J. A., Low D. A. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. Int J Radiat Oncol Biol Phys. 2001 Mar 15;49(4):907–916. doi: 10.1016/s0360-3016(00)01441-3. [DOI] [PubMed] [Google Scholar]
  5. Chao K. S., Low D. A., Perez C. A., Purdy J. A. Intensity-modulated radiation therapy in head and neck cancers: The Mallinckrodt experience. Int J Cancer. 2000 Apr 20;90(2):92–103. doi: 10.1002/(sici)1097-0215(20000420)90:2<92::aid-ijc5>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  6. Chatani M., Matayoshi Y., Masaki N., Teshima T., Inoue T. A prospective randomized study concerning the point A dose in high-dose rate intracavitary therapy for carcinoma of the uterine cervix. The final results. Strahlenther Onkol. 1994 Nov;170(11):636–642. [PubMed] [Google Scholar]
  7. Chatani M., Matayoshi Y., Masaki N., Teshima T., Inoue T. Long term follow-up results of high-dose rate remote afterloading intracavitary radiation therapy for carcinoma of the uterine cervix. Strahlenther Onkol. 1994 May;170(5):269–276. [PubMed] [Google Scholar]
  8. Coffey R. J., Nichols D. A., Shaw E. G. Stereotactic radiosurgical treatment of cerebral arteriovenous malformations. Gamma Unit Radiosurgery Study Group. Mayo Clin Proc. 1995 Mar;70(3):214–222. doi: 10.4065/70.3.214. [DOI] [PubMed] [Google Scholar]
  9. Condado J. A., Waksman R., Gurdiel O., Espinosa R., Gonzalez J., Burger B., Villoria G., Acquatella H., Crocker I. R., Seung K. B. Long-term angiographic and clinical outcome after percutaneous transluminal coronary angioplasty and intracoronary radiation therapy in humans. Circulation. 1997 Aug 5;96(3):727–732. doi: 10.1161/01.cir.96.3.727. [DOI] [PubMed] [Google Scholar]
  10. Curran W. J., Jr, Scott C. B., Weinstein A. S., Martin L. A., Nelson J. S., Phillips T. L., Murray K., Fischbach A. J., Yakar D., Schwade J. G. Survival comparison of radiosurgery-eligible and -ineligible malignant glioma patients treated with hyperfractionated radiation therapy and carmustine: a report of Radiation Therapy Oncology Group 83-02. J Clin Oncol. 1993 May;11(5):857–862. doi: 10.1200/JCO.1993.11.5.857. [DOI] [PubMed] [Google Scholar]
  11. De Meerleer G. O., Vakaet L. A., De Gersem W. R., De Wagter C., De Naeyer B., De Neve W. Radiotherapy of prostate cancer with or without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys. 2000 Jun 1;47(3):639–648. doi: 10.1016/s0360-3016(00)00419-3. [DOI] [PubMed] [Google Scholar]
  12. Duma C. M., Jacques D. B., Kopyov O. V., Mark R. J., Copcutt B., Farokhi H. K. Gamma knife radiosurgery for thalamotomy in parkinsonian tremor: a five-year experience. J Neurosurg. 1998 Jun;88(6):1044–1049. doi: 10.3171/jns.1998.88.6.1044. [DOI] [PubMed] [Google Scholar]
  13. Eisbruch A., Kim H. M., Terrell J. E., Marsh L. H., Dawson L. A., Ship J. A. Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001 Jul 1;50(3):695–704. doi: 10.1016/s0360-3016(01)01512-7. [DOI] [PubMed] [Google Scholar]
  14. Eisbruch A., Ship J. A., Martel M. K., Ten Haken R. K., Marsh L. H., Wolf G. T., Esclamado R. M., Bradford C. R., Terrell J. E., Gebarski S. S. Parotid gland sparing in patients undergoing bilateral head and neck irradiation: techniques and early results. Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):469–480. doi: 10.1016/s0360-3016(96)00264-7. [DOI] [PubMed] [Google Scholar]
  15. Erbel R., Haude M., Höpp H. W., Franzen D., Rupprecht H. J., Heublein B., Fischer K., de Jaegere P., Serruys P., Rutsch W. Coronary-artery stenting compared with balloon angioplasty for restenosis after initial balloon angioplasty. Restenosis Stent Study Group. N Engl J Med. 1998 Dec 3;339(23):1672–1678. doi: 10.1056/NEJM199812033392304. [DOI] [PubMed] [Google Scholar]
  16. Fischman D. L., Leon M. B., Baim D. S., Schatz R. A., Savage M. P., Penn I., Detre K., Veltri L., Ricci D., Nobuyoshi M. A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease. Stent Restenosis Study Investigators. N Engl J Med. 1994 Aug 25;331(8):496–501. doi: 10.1056/NEJM199408253310802. [DOI] [PubMed] [Google Scholar]
  17. Flickinger J. C., Kondziolka D., Pollock B. E., Lunsford L. D. Evolution in technique for vestibular schwannoma radiosurgery and effect on outcome. Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):275–280. doi: 10.1016/s0360-3016(96)00335-5. [DOI] [PubMed] [Google Scholar]
  18. Flickinger J. C., Kondziolka D., Pollock B. E., Maitz A. H., Lunsford L. D. Complications from arteriovenous malformation radiosurgery: multivariate analysis and risk modeling. Int J Radiat Oncol Biol Phys. 1997 Jun 1;38(3):485–490. doi: 10.1016/s0360-3016(97)89481-3. [DOI] [PubMed] [Google Scholar]
  19. Flickinger JC, Kondziolka D, Lunsford LD. Radiosurgery of Benign Lesions. Semin Radiat Oncol. 1995 Jul;5(3):220–224. doi: 10.1054/SRAO00500220. [DOI] [PubMed] [Google Scholar]
  20. Foote R. L., Coffey R. J., Swanson J. W., Harner S. G., Beatty C. W., Kline R. W., Stevens L. N., Hu T. C. Stereotactic radiosurgery using the gamma knife for acoustic neuromas. Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1153–1160. doi: 10.1016/0360-3016(94)00454-s. [DOI] [PubMed] [Google Scholar]
  21. Gollins S. W., Burt P. A., Barber P. V., Stout R. High dose rate intraluminal radiotherapy for carcinoma of the bronchus: outcome of treatment of 406 patients. Radiother Oncol. 1994 Oct;33(1):31–40. doi: 10.1016/0167-8140(94)90083-3. [DOI] [PubMed] [Google Scholar]
  22. Gunderson L. L., Sosin H. Areas of failure found at reoperation (second or symptomatic look) following "curative surgery" for adenocarcinoma of the rectum. Clinicopathologic correlation and implications for adjuvant therapy. Cancer. 1974 Oct;34(4):1278–1292. doi: 10.1002/1097-0142(197410)34:4<1278::aid-cncr2820340440>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  23. Jankovic J., Cardoso F., Grossman R. G., Hamilton W. J. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery. 1995 Oct;37(4):680–687. doi: 10.1227/00006123-199510000-00011. [DOI] [PubMed] [Google Scholar]
  24. Jyothirmayi R., Saran F. H., Jalali R., Perks J., Warrington A. P., Traish D., Ashley S., Hines F., Brada M. Stereotactic radiotherapy for solitary brain metastases. Clin Oncol (R Coll Radiol) 2001;13(3):228–234. doi: 10.1053/clon.2001.9258. [DOI] [PubMed] [Google Scholar]
  25. Kattan M. W., Potters L., Blasko J. C., Beyer D. C., Fearn P., Cavanagh W., Leibel S., Scardino P. T. Pretreatment nomogram for predicting freedom from recurrence after permanent prostate brachytherapy in prostate cancer. Urology. 2001 Sep;58(3):393–399. doi: 10.1016/s0090-4295(01)01233-x. [DOI] [PubMed] [Google Scholar]
  26. Kim D. G., Chung H. T., Gwak H. S., Paek S. H., Jung H. W., Han D. H. Gamma knife radiosurgery for brain metastases: prognostic factors for survival and local control. J Neurosurg. 2000 Dec;93 (Suppl 3):23–29. doi: 10.3171/jns.2000.93.supplement. [DOI] [PubMed] [Google Scholar]
  27. Kondziolka D., Lunsford L. D., Flickinger J. C. Controversies in the management of multiple brain metastases: the roles of radiosurgery and radiation therapy. Forum (Genova) 2001 Jan-Mar;11(1):47–58. [PubMed] [Google Scholar]
  28. Kuppersmith R. B., Greco S. C., Teh B. S., Donovan D. T., Grant W., Chiu J. K., Cain R. B., Butler E. B. Intensity-modulated radiotherapy: first results with this new technology on neoplasms of the head and neck. Ear Nose Throat J. 1999 Apr;78(4):238, 241-6, 248 passim. [PubMed] [Google Scholar]
  29. Landry Jerome C., Yang Gary Y., Ting Joseph Y., Staley Charles A., Torres William, Esiashvili Natia, Davis Lawrence W. Treatment of pancreatic cancer tumors with intensity-modulated radiation therapy (IMRT) using the volume at risk approach (VARA): employing dose-volume histogram (DVH) and normal tissue complication probability (NTCP) to evaluate small bowel toxicity. Med Dosim. 2002 Summer;27(2):121–129. doi: 10.1016/s0958-3947(02)00094-8. [DOI] [PubMed] [Google Scholar]
  30. Larson D. A., Gutin P. H., McDermott M., Lamborn K., Sneed P. K., Wara W. M., Flickinger J. C., Kondziolka D., Lunsford L. D., Hudgins W. R. Gamma knife for glioma: selection factors and survival. Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1045–1053. doi: 10.1016/s0360-3016(96)00427-0. [DOI] [PubMed] [Google Scholar]
  31. Leon M. B., Teirstein P. S., Moses J. W., Tripuraneni P., Lansky A. J., Jani S., Wong S. C., Fish D., Ellis S., Holmes D. R. Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting. N Engl J Med. 2001 Jan 25;344(4):250–256. doi: 10.1056/NEJM200101253440402. [DOI] [PubMed] [Google Scholar]
  32. Liu M. W., Roubin G. S., King S. B., 3rd Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation. 1989 Jun;79(6):1374–1387. doi: 10.1161/01.cir.79.6.1374. [DOI] [PubMed] [Google Scholar]
  33. Loeffler J. S., Alexander E., 3rd, Shea W. M., Wen P. Y., Fine H. A., Kooy H. M., Black P. M. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol. 1992 Sep;10(9):1379–1385. doi: 10.1200/JCO.1992.10.9.1379. [DOI] [PubMed] [Google Scholar]
  34. Ma L., Yu C. X., Earl M., Holmes T., Sarfaraz M., Li X. A., Shepard D., Amin P., DiBiase S., Suntharalingam M. Optimized intensity-modulated arc therapy for prostate cancer treatment. Int J Cancer. 2001 Dec 20;96(6):379–384. doi: 10.1002/ijc.1039. [DOI] [PubMed] [Google Scholar]
  35. Mak K. H., Topol E. J. Clinical trials to prevent restenosis after percutaneous coronary revascularization. Ann N Y Acad Sci. 1997 Apr 15;811:255–288. doi: 10.1111/j.1749-6632.1997.tb52007.x. [DOI] [PubMed] [Google Scholar]
  36. Marks L. B., Spencer D. P., Sherouse G. W., Bentel G., Clough R., Vann K., Jaszczak R., Coleman R. E., Prosnitz L. R. The role of three dimensional functional lung imaging in radiation treatment planning: the functional dose-volume histogram. Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):65–75. doi: 10.1016/0360-3016(95)00091-C. [DOI] [PubMed] [Google Scholar]
  37. Martel M. K., Sandler H. M., Cornblath W. T., Marsh L. H., Hazuka M. B., Roa W. H., Fraass B. A., Lichter A. S. Dose-volume complication analysis for visual pathway structures of patients with advanced paranasal sinus tumors. Int J Radiat Oncol Biol Phys. 1997 May 1;38(2):273–284. doi: 10.1016/s0360-3016(97)00029-1. [DOI] [PubMed] [Google Scholar]
  38. Martinez A. A., Yan D., Lockman D., Brabbins D., Kota K., Sharpe M., Jaffray D. A., Vicini F., Wong J. Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer. Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1226–1234. doi: 10.1016/s0360-3016(01)01552-8. [DOI] [PubMed] [Google Scholar]
  39. Mate T. P., Gottesman J. E., Hatton J., Gribble M., Van Hollebeke L. High dose-rate afterloading 192Iridium prostate brachytherapy: feasibility report. Int J Radiat Oncol Biol Phys. 1998 Jun 1;41(3):525–533. doi: 10.1016/s0360-3016(98)00097-2. [DOI] [PubMed] [Google Scholar]
  40. McGinn C. J., Ten Haken R. K., Ensminger W. D., Walker S., Wang S., Lawrence T. S. Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model. J Clin Oncol. 1998 Jun;16(6):2246–2252. doi: 10.1200/JCO.1998.16.6.2246. [DOI] [PubMed] [Google Scholar]
  41. Mehta M. P., Masciopinto J., Rozental J., Levin A., Chappell R., Bastin K., Miles J., Turski P., Kubsad S., Mackie T. Stereotactic radiosurgery for glioblastoma multiforme: report of a prospective study evaluating prognostic factors and analyzing long-term survival advantage. Int J Radiat Oncol Biol Phys. 1994 Oct 15;30(3):541–549. doi: 10.1016/0360-3016(92)90939-f. [DOI] [PubMed] [Google Scholar]
  42. Nutting C. M., Convery D. J., Cosgrove V. P., Rowbottom C., Padhani A. R., Webb S., Dearnaley D. P. Reduction of small and large bowel irradiation using an optimized intensity-modulated pelvic radiotherapy technique in patients with prostate cancer. Int J Radiat Oncol Biol Phys. 2000 Oct 1;48(3):649–656. doi: 10.1016/s0360-3016(00)00653-2. [DOI] [PubMed] [Google Scholar]
  43. Petereit D. G., Sarkaria J. N., Potter D. M., Schink J. C. High-dose-rate versus low-dose-rate brachytherapy in the treatment of cervical cancer: analysis of tumor recurrence--the University of Wisconsin experience. Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1267–1274. doi: 10.1016/s0360-3016(99)00262-x. [DOI] [PubMed] [Google Scholar]
  44. Roach M., 3rd, Chinn D. M., Holland J., Clarke M. A pilot survey of sexual function and quality of life following 3D conformal radiotherapy for clinically localized prostate cancer. Int J Radiat Oncol Biol Phys. 1996 Jul 15;35(5):869–874. doi: 10.1016/0360-3016(96)00206-4. [DOI] [PubMed] [Google Scholar]
  45. Robertson J. M., Ten Haken R. K., Hazuka M. B., Turrisi A. T., Martel M. K., Pu A. T., Littles J. F., Martinez F. J., Francis I. R., Quint L. E. Dose escalation for non-small cell lung cancer using conformal radiation therapy. Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1079–1085. doi: 10.1016/s0360-3016(96)00593-7. [DOI] [PubMed] [Google Scholar]
  46. Salter B. J., Fuss M., Vollmer D. G., Sadeghi A., Bogaev C. A., Cheek D. A., Herman T. S., Hevezi J. M. The TALON removable head frame system for stereotactic radiosurgery/radiotherapy: measurement of the repositioning accuracy. Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):555–562. doi: 10.1016/s0360-3016(01)01670-4. [DOI] [PubMed] [Google Scholar]
  47. Sandler H. M., McLaughlin P. W., Ten Haken R. K., Addison H., Forman J., Lichter A. Three dimensional conformal radiotherapy for the treatment of prostate cancer: low risk of chronic rectal morbidity observed in a large series of patients. Int J Radiat Oncol Biol Phys. 1995 Nov 1;33(4):797–801. doi: 10.1016/0360-3016(95)00219-7. [DOI] [PubMed] [Google Scholar]
  48. Sarkaria J. N., Mehta M. P., Loeffler J. S., Buatti J. M., Chappell R. J., Levin A. B., Alexander E., 3rd, Friedman W. A., Kinsella T. J. Radiosurgery in the initial management of malignant gliomas: survival comparison with the RTOG recursive partitioning analysis. Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):931–941. doi: 10.1016/0360-3016(94)00621-q. [DOI] [PubMed] [Google Scholar]
  49. Serruys P. W., de Jaegere P., Kiemeneij F., Macaya C., Rutsch W., Heyndrickx G., Emanuelsson H., Marco J., Legrand V., Materne P. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group. N Engl J Med. 1994 Aug 25;331(8):489–495. doi: 10.1056/NEJM199408253310801. [DOI] [PubMed] [Google Scholar]
  50. Shiau C. Y., Sneed P. K., Shu H. K., Lamborn K. R., McDermott M. W., Chang S., Nowak P., Petti P. L., Smith V., Verhey L. J. Radiosurgery for brain metastases: relationship of dose and pattern of enhancement to local control. Int J Radiat Oncol Biol Phys. 1997 Jan 15;37(2):375–383. doi: 10.1016/s0360-3016(96)00497-x. [DOI] [PubMed] [Google Scholar]
  51. Shu H. K., Lee T. T., Vigneauly E., Xia P., Pickett B., Phillips T. L., Roach M. Toxicity following high-dose three-dimensional conformal and intensity-modulated radiation therapy for clinically localized prostate cancer. Urology. 2001 Jan;57(1):102–107. doi: 10.1016/s0090-4295(00)00890-6. [DOI] [PubMed] [Google Scholar]
  52. Shu H. K., Sneed P. K., Shiau C. Y., McDermott M. W., Lamborn K. R., Park E., Ho M., Petti P. L., Smith V., Verhey L. J. Factors influencing survival after gamma knife radiosurgery for patients with single and multiple brain metastases. Cancer J Sci Am. 1996 Nov-Dec;2(6):335–342. [PubMed] [Google Scholar]
  53. Sterling T. D., Knowlton K. C., Weinkam J. J., Sterling D. M. Dynamic display of radiotherapy plans using computer-produced films. Radiology. 1973 Jun;107(3):689–691. doi: 10.1148/107.3.689. [DOI] [PubMed] [Google Scholar]
  54. Streeter O. E., Jr, Goldson A. L., Chevallier C., Nibhanupudy J. R. High dose rate 60Co remote afterloading irradiation in cancer of the cervix in Haiti, 1977-1984. Int J Radiat Oncol Biol Phys. 1988 Jun;14(6):1159–1163. doi: 10.1016/0360-3016(88)90393-8. [DOI] [PubMed] [Google Scholar]
  55. Teh B. S., Mai W. Y., Uhl B. M., Augspurger M. E., Grant W. H., 3rd, Lu H. H., Woo S. Y., Carpenter L. S., Chiu J. K., Butler E. B. Intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of a rectal balloon for prostate immobilization: acute toxicity and dose-volume analysis. Int J Radiat Oncol Biol Phys. 2001 Mar 1;49(3):705–712. doi: 10.1016/s0360-3016(00)01428-0. [DOI] [PubMed] [Google Scholar]
  56. Teirstein P. S., Massullo V., Jani S., Popma J. J., Russo R. J., Schatz R. A., Guarneri E. M., Steuterman S., Sirkin K., Cloutier D. A. Three-year clinical and angiographic follow-up after intracoronary radiation : results of a randomized clinical trial. Circulation. 2000 Feb 1;101(4):360–365. doi: 10.1161/01.cir.101.4.360. [DOI] [PubMed] [Google Scholar]
  57. Verin V., Popowski Y., de Bruyne B., Baumgart D., Sauerwein W., Lins M., Kovacs G., Thomas M., Calman F., Disco C. Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. The Dose-Finding Study Group. N Engl J Med. 2001 Jan 25;344(4):243–249. doi: 10.1056/NEJM200101253440401. [DOI] [PubMed] [Google Scholar]
  58. Vicini F. A., Baglan K. L., Kestin L. L., Mitchell C., Chen P. Y., Frazier R. C., Edmundson G., Goldstein N. S., Benitez P., Huang R. R. Accelerated treatment of breast cancer. J Clin Oncol. 2001 Apr 1;19(7):1993–2001. doi: 10.1200/JCO.2001.19.7.1993. [DOI] [PubMed] [Google Scholar]
  59. Wallner K. Improved outcomes with radiation for prostate cancer. Hematol Oncol Clin North Am. 2001 Apr;15(2):359–375. doi: 10.1016/s0889-8588(05)70217-3. [DOI] [PubMed] [Google Scholar]
  60. Wallner K., Roy J., Harrison L. Tumor control and morbidity following transperineal iodine 125 implantation for stage T1/T2 prostatic carcinoma. J Clin Oncol. 1996 Feb;14(2):449–453. doi: 10.1200/JCO.1996.14.2.449. [DOI] [PubMed] [Google Scholar]
  61. Young R. F., Shumway-Cook A., Vermeulen S. S., Grimm P., Blasko J., Posewitz A., Burkhart W. A., Goiney R. C. Gamma knife radiosurgery as a lesioning technique in movement disorder surgery. J Neurosurg. 1998 Aug;89(2):183–193. doi: 10.3171/jns.1998.89.2.0183. [DOI] [PubMed] [Google Scholar]
  62. Zelefsky M. J., Fuks Z., Happersett L., Lee H. J., Ling C. C., Burman C. M., Hunt M., Wolfe T., Venkatraman E. S., Jackson A. Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer. Radiother Oncol. 2000 Jun;55(3):241–249. doi: 10.1016/s0167-8140(99)00100-0. [DOI] [PubMed] [Google Scholar]
  63. Zelefsky M. J., Hollister T., Raben A., Matthews S., Wallner K. E. Five-year biochemical outcome and toxicity with transperineal CT-planned permanent I-125 prostate implantation for patients with localized prostate cancer. Int J Radiat Oncol Biol Phys. 2000 Jul 15;47(5):1261–1266. doi: 10.1016/s0360-3016(00)00550-2. [DOI] [PubMed] [Google Scholar]
  64. Zelefsky M. J., Wallner K. E., Ling C. C., Raben A., Hollister T., Wolfe T., Grann A., Gaudin P., Fuks Z., Leibel S. A. Comparison of the 5-year outcome and morbidity of three-dimensional conformal radiotherapy versus transperineal permanent iodine-125 implantation for early-stage prostatic cancer. J Clin Oncol. 1999 Feb;17(2):517–522. doi: 10.1200/JCO.1999.17.2.517. [DOI] [PubMed] [Google Scholar]

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