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Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 2003 Feb;95(2):152–166.

Environmental factors associated with asthma.

Bailus Walker Jr 1, Lynette D Stokes 1, Rueben Warren 1
PMCID: PMC2594449  PMID: 12760611

Abstract

Asthma, a disease of attacks and remission, continues to account for substantial morbidity and direct economic costs. Numerous studies--epidemiologic, toxicologic and clinical--present evidence for a broad spectrum of environmental risk factors associated with asthma. This review summarizes current thinking on a subset of these factors. Knowledge of potential environmental determinants of asthma is important to both the patient and healthcare professional in the application of multiple modalities of medical and environmental intervention for management of the development, and exacerbation of this chronic inflammatory disorder of the airways.

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Selected References

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  1. Blixen C. E., Havstad S., Tilley B. C., Zoratti E. A comparison of asthma-related healthcare use between African-Americans and Caucasians belonging to a health maintenance organization (HMO). J Asthma. 1999;36(2):195–204. doi: 10.3109/02770909909056317. [DOI] [PubMed] [Google Scholar]
  2. Brown V. J. Old pesticides pose new problems for developing world. Environ Health Perspect. 2001 Dec;109(12):A578–A579. doi: 10.1289/ehp.109-a578b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Call R. S., Smith T. F., Morris E., Chapman M. D., Platts-Mills T. A. Risk factors for asthma in inner city children. J Pediatr. 1992 Dec;121(6):862–866. doi: 10.1016/s0022-3476(05)80329-4. [DOI] [PubMed] [Google Scholar]
  4. Christiani D. C. Organic dust exposure and chronic airway disease. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):833–834. doi: 10.1164/ajrccm.154.4.8887570. [DOI] [PubMed] [Google Scholar]
  5. Department of Health and Human Services. Panel on Clinical Practices for Treatment of HIV Infection. Henry J. Kaiser Family Foundation. Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents, January 28, 2000 by the Panel on Clinical Practices for Treatment of HIV Infection. HIV Clin Trials. 2000 Jul-Aug;1(1):60–110. doi: 10.1310/hct.2000.1.1.008. [DOI] [PubMed] [Google Scholar]
  6. Eggleston P. A., Rosenstreich D., Lynn H., Gergen P., Baker D., Kattan M., Mortimer K. M., Mitchell H., Ownby D., Slavin R. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563–570. doi: 10.1016/s0091-6749(98)70272-6. [DOI] [PubMed] [Google Scholar]
  7. Eggleston P. A., Rosenstreich D., Lynn H., Gergen P., Baker D., Kattan M., Mortimer K. M., Mitchell H., Ownby D., Slavin R. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563–570. doi: 10.1016/s0091-6749(98)70272-6. [DOI] [PubMed] [Google Scholar]
  8. Ezzati M., Kammen D. M. Quantifying the effects of exposure to indoor air pollution from biomass combustion on acute respiratory infections in developing countries. Environ Health Perspect. 2001 May;109(5):481–488. doi: 10.1289/ehp.01109481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gwynn R. C., Thurston G. D. The burden of air pollution: impacts among racial minorities. Environ Health Perspect. 2001 Aug;109 (Suppl 4):501–506. doi: 10.1289/ehp.01109s4501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Harber P., Merz B. Time and knowledge barriers to recognizing occupational disease. J Occup Environ Med. 2001 Mar;43(3):285–288. doi: 10.1097/00043764-200103000-00019. [DOI] [PubMed] [Google Scholar]
  11. Jaakkola Maritta S., Nordman Henrik, Piipari Ritva, Uitti Jukka, Laitinen Jukka, Karjalainen Antti, Hahtola Paula, Jaakkola Jouni J. K. Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study. Environ Health Perspect. 2002 May;110(5):543–547. doi: 10.1289/ehp.02110543. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jordanov J. S. Cotinine concentrations in amniotic fluid and urine of smoking, passive smoking and non-smoking pregnant women at term and in the urine of their neonates on 1st day of life. Eur J Pediatr. 1990 Jul;149(10):734–737. doi: 10.1007/BF01959534. [DOI] [PubMed] [Google Scholar]
  13. Koren H. S. Associations between criteria air pollutants and asthma. Environ Health Perspect. 1995 Sep;103 (Suppl 6):235–242. doi: 10.1289/ehp.95103s6235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Krishnan J. A., Diette G. B., Skinner E. A., Clark B. D., Steinwachs D., Wu A. W. Race and sex differences in consistency of care with national asthma guidelines in managed care organizations. Arch Intern Med. 2001 Jul 9;161(13):1660–1668. doi: 10.1001/archinte.161.13.1660. [DOI] [PubMed] [Google Scholar]
  15. Landrigan P. J. Health consequences of the 11 September 2001 attacks. Environ Health Perspect. 2001 Nov;109(11):A514–A515. doi: 10.1289/ehp.109-a514. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Lynch R. M. Modeling of exposure to carpet-cleaning chemicals preceding irritant-induced asthma in one patient. Environ Health Perspect. 2000 Sep;108(9):911–913. doi: 10.1289/ehp.00108911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Michel O., Ginanni R., Duchateau J., Vertongen F., Le Bon B., Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy. 1991 Jul;21(4):441–448. doi: 10.1111/j.1365-2222.1991.tb01684.x. [DOI] [PubMed] [Google Scholar]
  18. Michel O., Ginanni R., Duchateau J., Vertongen F., Le Bon B., Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy. 1991 Jul;21(4):441–448. doi: 10.1111/j.1365-2222.1991.tb01684.x. [DOI] [PubMed] [Google Scholar]
  19. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., Pauwels R., Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1641–1646. doi: 10.1164/ajrccm.154.6.8970348. [DOI] [PubMed] [Google Scholar]
  20. Michel O., Kips J., Duchateau J., Vertongen F., Robert L., Collet H., Pauwels R., Sergysels R. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1641–1646. doi: 10.1164/ajrccm.154.6.8970348. [DOI] [PubMed] [Google Scholar]
  21. Murray A. B., Morrison B. J. Passive smoking by asthmatics: its greater effect on boys than on girls and on older than on younger children. Pediatrics. 1989 Sep;84(3):451–459. [PubMed] [Google Scholar]
  22. O'Connor G. T., Gold D. R. Cockroach allergy and asthma in a 30-year-old man. Environ Health Perspect. 1999 Mar;107(3):243–247. doi: 10.1289/ehp.99107243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Pandya Robert J., Solomon Gina, Kinner Amy, Balmes John R. Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect. 2002 Feb;110 (Suppl 1):103–112. doi: 10.1289/ehp.02110s1103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Pope C. A., 3rd, Dockery D. W. Acute health effects of PM10 pollution on symptomatic and asymptomatic children. Am Rev Respir Dis. 1992 May;145(5):1123–1128. doi: 10.1164/ajrccm/145.5.1123. [DOI] [PubMed] [Google Scholar]
  25. Rylander R., Haglind P. Airborne endotoxins and humidifier disease. Clin Allergy. 1984 Jan;14(1):109–112. doi: 10.1111/j.1365-2222.1984.tb02197.x. [DOI] [PubMed] [Google Scholar]
  26. Sarpong S. B., Hamilton R. G., Eggleston P. A., Adkinson N. F., Jr Socioeconomic status and race as risk factors for cockroach allergen exposure and sensitization in children with asthma. J Allergy Clin Immunol. 1996 Jun;97(6):1393–1401. doi: 10.1016/s0091-6749(96)70209-9. [DOI] [PubMed] [Google Scholar]
  27. Sarpong S. B., Karrison T. Skin test reactivity to indoor allergens as a marker of asthma severity in children with asthma. Ann Allergy Asthma Immunol. 1998 Apr;80(4):303–308. doi: 10.1016/S1081-1206(10)62973-0. [DOI] [PubMed] [Google Scholar]
  28. Schou C. Defining allergens of mammalian origin. Clin Exp Allergy. 1993 Jan;23(1):7–14. doi: 10.1111/j.1365-2222.1993.tb02477.x. [DOI] [PubMed] [Google Scholar]
  29. Smedje G., Norbäck D. New ventilation systems at select schools in Sweden--effects on asthma and exposure. Arch Environ Health. 2000 Jan-Feb;55(1):18–25. doi: 10.1080/00039890009603380. [DOI] [PubMed] [Google Scholar]
  30. Sporik R., Holgate S. T., Platts-Mills T. A., Cogswell J. J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med. 1990 Aug 23;323(8):502–507. doi: 10.1056/NEJM199008233230802. [DOI] [PubMed] [Google Scholar]
  31. Taylor Philip E., Flagan Richard C., Valenta Rudolf, Glovsky M. Michael. Release of allergens as respirable aerosols: A link between grass pollen and asthma. J Allergy Clin Immunol. 2002 Jan;109(1):51–56. doi: 10.1067/mai.2002.120759. [DOI] [PubMed] [Google Scholar]
  32. Taylor S. L., Hefle S. L. Will genetically modified foods be allergenic? J Allergy Clin Immunol. 2001 May;107(5):765–771. doi: 10.1067/mai.2001.114241. [DOI] [PubMed] [Google Scholar]
  33. Vanto T., Koivikko A. Dog hypersensitivity in asthmatic children. A clinical study with special reference to the relationship between the exposure to dogs and the occurrence of hypersensitivity symptoms. Acta Paediatr Scand. 1983 Jul;72(4):571–575. doi: 10.1111/j.1651-2227.1983.tb09773.x. [DOI] [PubMed] [Google Scholar]
  34. Vojta P. J., Randels S. P., Stout J., Muilenberg M., Burge H. A., Lynn H., Mitchell H., O'Connor G. T., Zeldin D. C. Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes. Environ Health Perspect. 2001 Aug;109(8):815–819. doi: 10.1289/ehp.01109815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Warner J. A. Environmental allergen exposure in homes and schools. Clin Exp Allergy. 1992 Dec;22(12):1044–1045. doi: 10.1111/j.1365-2222.1992.tb00127.x. [DOI] [PubMed] [Google Scholar]
  36. Woolcock A. J., Peat J. K. Evidence for the increase in asthma worldwide. Ciba Found Symp. 1997;206:122-34; discussion 134-9, 157-9. doi: 10.1002/9780470515334.ch8. [DOI] [PubMed] [Google Scholar]
  37. Zoratti E. M., Havstad S., Rodriguez J., Robens-Paradise Y., Lafata J. E., McCarthy B. Health service use by African Americans and Caucasians with asthma in a managed care setting. Am J Respir Crit Care Med. 1998 Aug;158(2):371–377. doi: 10.1164/ajrccm.158.2.9608039. [DOI] [PubMed] [Google Scholar]
  38. von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol. 2000 Jan;105(1 Pt 1):9–19. doi: 10.1016/s0091-6749(00)90171-4. [DOI] [PubMed] [Google Scholar]

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