Abstract
BACKGROUND: This study was performed to determine the relationship between overweight [body mass index (BMI) > or = 85th percentile] and asthma as determined by spirometry. METHOD: Spirometry was performed according to the American Thoracic Society guidelines, and BMI was calculated. Asthma was defined as a forced expiratory volume in 1 second (FEV1) <80% predicted and FEV1/forced vital capacity (FVC) >5% lower than predicted for age and sex. RESULTS: One-hundred-nine children (age 14.7 +/- 1.6 years) were enrolled. Eighty children (73%) were African-American, and 29 children (27%) were white. Fifty-eight (53%) children were overweight. Twelve (11%) children, of whom nine (75%) were overweight, met the criteria for asthma. Baseline FEV1 percent predicted (87 +/- 6% vs. 83 +/- 7%, p=0.03), FEV1/FVC (93 +/- 6 vs. 87 +/- 8, p<0.001), and FEV1 percent predicted following albuterol administration (94 +/- 7 vs. 89 +/- 7%, p=0.03) were all lower in overweight children. Children with asthma were almost 1.5 times more likely to be overweight compared with children without asthma (relative risk: 1.49, 95% confidence interval: 1.015-2.17). CONCLUSIONS: Inner-city children are more likely to be overweight compared to the general population. Asthma is a risk factor for overweight in these children.
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- Aligne C. A., Auinger P., Byrd R. S., Weitzman M. Risk factors for pediatric asthma. Contributions of poverty, race, and urban residence. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):873–877. doi: 10.1164/ajrccm.162.3.9908085. [DOI] [PubMed] [Google Scholar]
- Brenner J. S., Kelly C. S., Wenger A. D., Brich S. M., Morrow A. L. Asthma and obesity in adolescents: is there an association? J Asthma. 2001 Sep;38(6):509–515. doi: 10.1081/jas-100105872. [DOI] [PubMed] [Google Scholar]
- Cypcar D., Lemanske R. F., Jr Asthma and exercise. Clin Chest Med. 1994 Jun;15(2):351–368. [PubMed] [Google Scholar]
- Dietz W. H., Jr, Gortmaker S. L. Do we fatten our children at the television set? Obesity and television viewing in children and adolescents. Pediatrics. 1985 May;75(5):807–812. [PubMed] [Google Scholar]
- Ellis K. J., Abrams S. A., Wong W. W. Monitoring childhood obesity: assessment of the weight/height index. Am J Epidemiol. 1999 Nov 1;150(9):939–946. doi: 10.1093/oxfordjournals.aje.a010102. [DOI] [PubMed] [Google Scholar]
- Enright P. L., Linn W. S., Avol E. L., Margolis H. G., Gong H., Jr, Peters J. M. Quality of spirometry test performance in children and adolescents : experience in a large field study. Chest. 2000 Sep;118(3):665–671. doi: 10.1378/chest.118.3.665. [DOI] [PubMed] [Google Scholar]
- Evans D., Mellins R., Lobach K., Ramos-Bonoan C., Pinkett-Heller M., Wiesemann S., Klein I., Donahue C., Burke D., Levison M. Improving care for minority children with asthma: professional education in public health clinics. Pediatrics. 1997 Feb;99(2):157–164. doi: 10.1542/peds.99.2.157. [DOI] [PubMed] [Google Scholar]
- Figueroa-Muñoz J. I., Chinn S., Rona R. J. Association between obesity and asthma in 4-11 year old children in the UK. Thorax. 2001 Feb;56(2):133–137. doi: 10.1136/thorax.56.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gennuso J., Epstein L. H., Paluch R. A., Cerny F. The relationship between asthma and obesity in urban minority children and adolescents. Arch Pediatr Adolesc Med. 1998 Dec;152(12):1197–1200. doi: 10.1001/archpedi.152.12.1197. [DOI] [PubMed] [Google Scholar]
- Goldey D. H., Mansmann H. C., Jr, Rasmussen A. I. Zinc status of asthmatic, prednisone-treated asthmatic, and non-asthmatic children. J Am Diet Assoc. 1984 Feb;84(2):157–163. [PubMed] [Google Scholar]
- Hill J. O., Melanson E. L. Overview of the determinants of overweight and obesity: current evidence and research issues. Med Sci Sports Exerc. 1999 Nov;31(11 Suppl):S515–S521. doi: 10.1097/00005768-199911001-00005. [DOI] [PubMed] [Google Scholar]
- Himes J. H., Dietz W. H. Guidelines for overweight in adolescent preventive services: recommendations from an expert committee. The Expert Committee on Clinical Guidelines for Overweight in Adolescent Preventive Services. Am J Clin Nutr. 1994 Feb;59(2):307–316. doi: 10.1093/ajcn/59.2.307. [DOI] [PubMed] [Google Scholar]
- Kaplan B. A., Brush G., Mascie-Taylor C. G. The relationship of childhood asthma and wheezy bronchitis with height, weight and body mass index. Hum Biol. 1987 Dec;59(6):921–931. [PubMed] [Google Scholar]
- Kaplan T. A., Montana E. Exercise-induced bronchospasm in nonasthmatic obese children. Clin Pediatr (Phila) 1993 Apr;32(4):220–225. doi: 10.1177/000992289303200407. [DOI] [PubMed] [Google Scholar]
- Kawabori I., Pierson W. E., Conquest L. L., Bierman C. W. Incidence of exercise-induced asthma in children. J Allergy Clin Immunol. 1976 Oct;58(4):447–455. doi: 10.1016/0091-6749(76)90188-3. [DOI] [PubMed] [Google Scholar]
- Kuczmarski Robert J., Ogden Cynthia L., Guo Shumei S., Grummer-Strawn Laurence M., Flegal Katherine M., Mei Zuguo, Wei Rong, Curtin Lester R., Roche Alex F., Johnson Clifford L. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11. 2002 May;(246):1–190. [PubMed] [Google Scholar]
- Luder E., Melnik T. A., DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr. 1998 Apr;132(4):699–703. doi: 10.1016/s0022-3476(98)70363-4. [DOI] [PubMed] [Google Scholar]
- Mokdad A. H., Serdula M. K., Dietz W. H., Bowman B. A., Marks J. S., Koplan J. P. The spread of the obesity epidemic in the United States, 1991-1998. JAMA. 1999 Oct 27;282(16):1519–1522. doi: 10.1001/jama.282.16.1519. [DOI] [PubMed] [Google Scholar]
- Mossberg H. O. 40-year follow-up of overweight children. Lancet. 1989 Aug 26;2(8661):491–493. doi: 10.1016/s0140-6736(89)92098-9. [DOI] [PubMed] [Google Scholar]
- Must A., Jacques P. F., Dallal G. E., Bajema C. J., Dietz W. H. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med. 1992 Nov 5;327(19):1350–1355. doi: 10.1056/NEJM199211053271904. [DOI] [PubMed] [Google Scholar]
- Pearce N., Douwes J., Beasley R. The rise and rise of asthma: a new paradigm for the new millennium? J Epidemiol Biostat. 2000;5(1):5–16. [PubMed] [Google Scholar]
- Pietrobelli A., Faith M. S., Allison D. B., Gallagher D., Chiumello G., Heymsfield S. B. Body mass index as a measure of adiposity among children and adolescents: a validation study. J Pediatr. 1998 Feb;132(2):204–210. doi: 10.1016/s0022-3476(98)70433-0. [DOI] [PubMed] [Google Scholar]
- Schwartz J., Gold D., Dockery D. W., Weiss S. T., Speizer F. E. Predictors of asthma and persistent wheeze in a national sample of children in the United States. Association with social class, perinatal events, and race. Am Rev Respir Dis. 1990 Sep;142(3):555–562. doi: 10.1164/ajrccm/142.3.555. [DOI] [PubMed] [Google Scholar]
- To Teresa, Vydykhan Tatiana N., Dell Sharon, Tassoudji Marjan, Harris Jennifer K. Is obesity associated with asthma in young children? J Pediatr. 2004 Feb;144(2):162–168. doi: 10.1016/j.jpeds.2003.09.047. [DOI] [PubMed] [Google Scholar]
- Troiano R. P., Flegal K. M., Kuczmarski R. J., Campbell S. M., Johnson C. L. Overweight prevalence and trends for children and adolescents. The National Health and Nutrition Examination Surveys, 1963 to 1991. Arch Pediatr Adolesc Med. 1995 Oct;149(10):1085–1091. doi: 10.1001/archpedi.1995.02170230039005. [DOI] [PubMed] [Google Scholar]
- Wang X., Dockery D. W., Wypij D., Fay M. E., Ferris B. G., Jr Pulmonary function between 6 and 18 years of age. Pediatr Pulmonol. 1993 Feb;15(2):75–88. doi: 10.1002/ppul.1950150204. [DOI] [PubMed] [Google Scholar]
- Yeatts K., Shy C., Wiley J., Music S. Statewide adolescent asthma surveillance. J Asthma. 2000 Aug;37(5):425–434. doi: 10.3109/02770900009055468. [DOI] [PubMed] [Google Scholar]
- Yeatts Karin, Davis Kourtney Johnston, Sotir Mark, Herget Casey, Shy Carl. Who gets diagnosed with asthma? Frequent wheeze among adolescents with and without a diagnosis of asthma. Pediatrics. 2003 May;111(5 Pt 1):1046–1054. doi: 10.1542/peds.111.5.1046. [DOI] [PubMed] [Google Scholar]
- Zeitlin S. R., Bond S., Wootton S., Gregson R. K., Radford M. Increased resting energy expenditure in childhood asthma: does this contribute towards growth failure? Arch Dis Child. 1992 Nov;67(11):1366–1369. doi: 10.1136/adc.67.11.1366. [DOI] [PMC free article] [PubMed] [Google Scholar]
- von Kries R., Hermann M., Grunert V. P., von Mutius E. Is obesity a risk factor for childhood asthma? Allergy. 2001 Apr;56(4):318–322. doi: 10.1034/j.1398-9995.2001.00727.x. [DOI] [PubMed] [Google Scholar]
- von Mutius E., Schwartz J., Neas L. M., Dockery D., Weiss S. T. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001 Nov;56(11):835–838. doi: 10.1136/thorax.56.11.835. [DOI] [PMC free article] [PubMed] [Google Scholar]