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. 1978 May-Jun;51(3):275–282.

A Micropuncture Study of HCO3 Reabsorption by the Hypertrophied Proximal Tubule

Norman Bank, Wei-Shing Su, Hagop S Aynedjian
PMCID: PMC2595753  PMID: 735150

Abstract

In rats with renal failure produced by excision of one kidney and infarction of large portions of the other kidney, given a low calcium, high phosphorus diet for 2-3 weeks, GFR was reduced by 80 percent, the fractional excretion of sodium increased from 7 to 23 percent, that of bicarbonate from 16 to 23 percent and that of water from 4 to 13 percent. Single nephron GFR in the remaining nephrons was nearly doubled and end-proximal TF/PIn was depressed from 2.3 to 1.8, and proximal TF/PHCO3 from 0.52 to 0.35, the latter figure corresponding to an increase of absolute proximal HCO3 reabsorption from 1.7 to 3.5 nEq/min or from 2.8 to 3.2 Eq/L of single nephron glomerular filtrate. Acute parathyroidectomy had no influence on the fall of GFR or the rise of SNGFR in the remaining nephrons and failed to cause any significant changes in proximal tubular bicarbonate reabsorption. Parathyroidectomy, on the other hand, practically prevented the rise of the fractional excretion of sodium and of water and inverted the rise of the fractional excretion of bicarbonate to a fall. The data are interpreted to indicate that secondary hyperparathyroidism in renal failure impairs distal nephron bicarbonate and sodium reabsorption and, thus, contributes to the maintenance of sodium balance, but could possibly aggravate acidosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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