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. 1988 Sep;56(9):2400–2406. doi: 10.1128/iai.56.9.2400-2406.1988

Resistance to Plasmodium chabaudi in B10 mice: influence of the H-2 complex and testosterone.

F Wunderlich 1, H Mossmann 1, M Helwig 1, G Schillinger 1
PMCID: PMC259579  PMID: 3410544

Abstract

Resistance to Plasmodium chabaudi has been examined in different inbred mouse strains bearing identical H-2 haplotypes on different genetic backgrounds as well as in H-2-congenic mouse strains on B10 background. Resistance is expressed in terms of percent survival after a challenge with 10(6) P. chabaudi-infected erythrocytes. We can show that murine resistance to P. chabaudi is under complex polygenic control involving a non-H-2 gene(s) as well as genes in both I-A and I-E subregions of the H-2 complex. Our data indicate in particular that malaria protective antigens can be presented in context with I-Ab molecules but not in context with I-Ak molecules. Resistance controlled by I-Ab does not become apparent when I-Ek molecules are coincidentally expressed. Moreover, testosterone abrogates I-Ab-controlled resistance to P. chabaudi.

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Selected References

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