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. 1986 Nov;54(2):322–327. doi: 10.1128/iai.54.2.322-327.1986

Binding of Escherichia coli S fimbriae to human kidney epithelium.

T K Korhonen, J Parkkinen, J Hacker, J Finne, A Pere, M Rhen, H Holthöfer
PMCID: PMC260163  PMID: 2876958

Abstract

Purified S fimbriae and an Escherichia coli strain carrying the recombinant plasmid pANN801-4 that encodes S fimbriae were tested for adhesion to frozen sections of human kidney. The fimbriae and the bacteria bound to the same tissue domains, and in both cases the binding was specifically inhibited by the receptor analog of S fimbria, sialyl(alpha 2-3)lactose. S fimbriae bound specifically to the epithelial elements in the kidneys; to the epithelial cells of proximal and distal tubules as well as of the collecting ducts and to the visceral and parietal glomerular epithelium. In addition, they bound to the vascular endothelium of glomeruli and of the renal interstitium. No binding to connective tissue elements was observed. The results suggest that the biological function of S fimbriae is to mediate the adhesion of E. coli to human epithelial and vascular endothelial cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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