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. 1963 Oct;36(2):141–156.

The Pathogenesis of Duodenal Ulcer Disease in the Pantothenate-Deficient Rat ^**

Joseph Seronde Jr

PMCID: PMC2604519 PMID: 14067371

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

ALTHAUSEN T. L., DEMELENDEZ L. C., PEREZ-SANTIAGO E. Role of nutritional deficiencies in tropical sprue. Am J Clin Nutr. 1962 Jan;10:3–10. doi: 10.1093/ajcn/10.1.3. [DOI] [PubMed] [Google Scholar]
ARONSON A. R., NORFLEET R. G. The duodenal mucosa in peptic ulcer disease. A clinical pathological correlation. Am J Dig Dis. 1962 Jun;7:506–514. doi: 10.1007/BF02236129. [DOI] [PubMed] [Google Scholar]
BEAN W. B., HODGES R. E., DAUM K. Pantothenic acid deficiency induced in human subjects. J Clin Invest. 1955 Jul;34(7 Pt 1):1073–1084. doi: 10.1172/JCI103156. [DOI] [PMC free article] [PubMed] [Google Scholar]
BERG B. N. Duodenitis and duodenal ulcers produced in rats by pantothenic acid deficiency. Br J Exp Pathol. 1959 Aug;40:371–374. [PMC free article] [PubMed] [Google Scholar]
BERG B. N., ZUCKER T. F., ZUCKER L. M. Duodenal ulcers produced on a diet deficient in pantothenic acid. Proc Soc Exp Biol Med. 1949 Jul;71(3):374–376. doi: 10.3181/00379727-71-17196. [DOI] [PubMed] [Google Scholar]
CHUNG A. S., PEARSON W. N., DARBY W. J., MILLER O. N., GOLDSMITH G. A. Folic acid, viramin B6, pantothenic acid and vitamin B12 in human dietaries. Am J Clin Nutr. 1961 Sep-Oct;9:573–582. doi: 10.1093/ajcn/9.5.573. [DOI] [PubMed] [Google Scholar]
DEMOLE M. [Ulcerous disease of the duodenum without ulcer lesion]. Arch Mal Appar Dig Mal Nutr. 1960 Apr;49:426–434. [PubMed] [Google Scholar]
DONIACH I., SHINER M. Duodenal and jejunal biopsies. II. Histology. Gastroenterology. 1957 Jul;33(1):71–86. [PubMed] [Google Scholar]
EVERSON G., NORTHROP L., CHUNG N. Y., GETTY R. Effect of ascorbic acid on rats deprived of pantothenic acid during pregnancy. J Nutr. 1954 Oct 11;54(2):305–311. doi: 10.1093/jn/54.2.305. [DOI] [PubMed] [Google Scholar]
GOODWIN R. F. Some clinical and experimental observations on naturally-occurring pantothenic-acid deficiency in pigs. J Comp Pathol. 1962 Apr;72:214–232. doi: 10.1016/s0368-1742(62)80025-3. [DOI] [PubMed] [Google Scholar]
HIRSCHOWITZ B. I., BALINT J. A., FULTON W. F. Gastroduodenal endoscopy with the fiberscope--an analysis of 500 examinations. Surg Clin North Am. 1962 Oct;42:1081–1090. doi: 10.1016/s0039-6109(16)36777-9. [DOI] [PubMed] [Google Scholar]
HODGES R. E., BEAN W. B., OHLSON M. A., BLEILER R. E. Factors affecting human antibody response. III. Immunologic responses of men deficient in pantothenic acid. Am J Clin Nutr. 1962 Aug;11:85–93. doi: 10.1093/ajcn/11.2.85. [DOI] [PubMed] [Google Scholar]
HODGES R. E., BEAN W. B., OHLSON M. A., BLEILER R. E. Factors affecting human antibody response. V. Combined deficiencies of pantothenic acid and pyridoxine. Am J Clin Nutr. 1962 Sep;11:187–199. doi: 10.1093/ajcn/11.3.187. [DOI] [PubMed] [Google Scholar]
HODGES R. E., BEAN W. B., OHLSON M. A., BLEILER R. Human pantothenic acid deficiency produced by omega-methyl pantothenic acid. J Clin Invest. 1959 Aug;38(8):1421–1425. doi: 10.1172/JCI103918. [DOI] [PMC free article] [PubMed] [Google Scholar]
HODGES R. E., OHLSON M. A., BEAN W. B. Pantothenic acid deficiency in man. J Clin Invest. 1958 Nov;37(11):1642–1657. doi: 10.1172/JCI103756. [DOI] [PMC free article] [PubMed] [Google Scholar]
LEBLOND C. P., STEVENS C. E. The constant renewal of the intestinal epithelium in the albino rat. Anat Rec. 1948 Mar;100(3):357–377. doi: 10.1002/ar.1091000306. [DOI] [PubMed] [Google Scholar]
NELSON M. M., EVANS H. M. Sparing action of protein on pantothenic acid requirement of rat; fibrin as the protein component. Proc Soc Exp Biol Med. 1947 Nov;66(2):299–301. doi: 10.3181/00379727-66-16070. [DOI] [PubMed] [Google Scholar]
OSTROW J. D., RESNICK R. H. Hyperchlorhydria, duodenitis and duodenal ulcer: a clinical study of their interrelationships. Ann Intern Med. 1959 Dec;51:1303–1328. doi: 10.7326/0003-4819-51-6-1303. [DOI] [PubMed] [Google Scholar]
PADYKULA H. A., STRAUSS E. W., LADMAN A. J., GARDNER F. H. A morphologic and histochemical analysis of the human jejunal epithelium in nontropical sprue. Gastroenterology. 1961 Jun;40:735–765. [PubMed] [Google Scholar]
POLACEK M. A., CLOSE A. S., ELLISON E. H. Postoperative adynamic ileus: an experimental evaluation of the role of D-pantothenyl alcohol. J Surg Res. 1961 Sep;1:228–230. doi: 10.1016/s0022-4804(61)80049-8. [DOI] [PubMed] [Google Scholar]
SERONDE J., Jr Cardiac lesions and related findings in young vitamin B6-deficient rats. J Nutr. 1960 Sep;72:53–65. doi: 10.1093/jn/72.1.53. [DOI] [PubMed] [Google Scholar]
SERONDE J., Jr Resistance of rats to inoculation with Corynebacterium pathogenic in pantothenate deficiency. Proc Soc Exp Biol Med. 1954 Mar;85(3):521–524. doi: 10.3181/00379727-85-20938. [DOI] [PubMed] [Google Scholar]
SHARMA G. L., JOHNSTON R. L., LUECKE R. W., HOEFER J. A., GRAY M. L., THORP F. A study of the pathology of the intestine and other organs of weanling pigs when fed a ration of natural feedstuffs low in pantothenic acid. Am J Vet Res. 1952 Jul;13(48):298–303. [PubMed] [Google Scholar]
SHEPPARD A. J., JOHNSON B. C. Pantothenic acid deficiency in the growing calf. J Nutr. 1957 Feb 10;61(2):195–205. doi: 10.1093/jn/61.2.195. [DOI] [PubMed] [Google Scholar]
STOTHERS S. C., SCHMIDT D. A., JOHNSTON R. L., HOEFER J. A., LUECKE R. W. The pantothenic acid requirement of the baby pig. J Nutr. 1955 Sep 10;57(1):47–53. doi: 10.1093/jn/57.1.47. [DOI] [PubMed] [Google Scholar]
THORNTON G. H., BEAN W. B., HODGES R. E. The effect of pantothenic acid deficiency of gastric secretion and motility. J Clin Invest. 1955 Jul;34(7 Pt 1):1085–1091. doi: 10.1172/JCI103157. [DOI] [PMC free article] [PubMed] [Google Scholar]
TRESKUNOV K. A., BELIAVSKAIA Ts Z. [Treatment of peptic ulcer with pantothenic acid]. Laboratorio. 1960 Aug;38:146–148. [PubMed] [Google Scholar]
VITALE J. J., HEGSTED D. M., DIGIORGIO J., ZAMCHECK N. Interrelations between pantothenic acid, protein and calorie intakes with respect to respiration and morphology of duodenal mucosa. Metabolism. 1953 Jul;2(4):367–374. [PubMed] [Google Scholar]
WARREN S., SOMMERS S. C. Pathogenesis of ulcerative colitis. Am J Pathol. 1949 Jul;25(4):657–679. [PMC free article] [PubMed] [Google Scholar]
ZAMCHECK N. Dynamic interaction among body nutrition, gut mucosal metabolism and morphology and transport across the mucosa. Fed Proc. 1960 Dec;19:855–864. [PubMed] [Google Scholar]
ZUCKER L. M., SERONDE J., Jr, ZUCKER T. F. Acetylating activity in the rat in relation to other signs of pantothenic acid deficiency. Arch Biochem Biophys. 1955 Mar;55(1):9–18. doi: 10.1016/0003-9861(55)90537-3. [DOI] [PubMed] [Google Scholar]
ZUCKER T. F. Pantothenic acid deficiency and its effect on the integrity and functions of the intestines. Am J Clin Nutr. 1958 Jan-Feb;6(1):65–74. doi: 10.1093/ajcn/6.1.65. [DOI] [PubMed] [Google Scholar]
ZUCKER T. F., ZUCKER L. M. Pantothenic acid deficiency and loss of natural resistance to a bacterial infection in the rat. Proc Soc Exp Biol Med. 1954 Mar;85(3):517–521. [PubMed] [Google Scholar]

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